Springer nature aug 2016 (372 resultados)
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Taschenbuch. Condición: Neu. Neuware - Stem cells have the ability to differentiate into all types of cells within the body, thus have great therapeutic potential for regenerative medicine to treat complicated disorders, like Parkinson's disease and spinal cord injury. There will also be many applications in drug development. Ho…wever, several roadblocks, such as safety issues and low efficiency of pluripotent stem cell (PSC) line derivation need to be resolved before their clinical application. This thesis focuses on these two areas, so as to find methods to overcome the limitation. It covers deriving embryonic stem cells (ESCs) from several different species and reports an efficient system to generate induced pluripotent stem cells (iPSCs), and the first iPSC mice in the world. The results in this thesis confirm that somatic cells can be fully reprogrammed with the four Yamanaka factors. In addition, we have found that the Dlk1-Dio3 region can be a potential molecular marker to distinguish the fully reprogrammed iPSCs from partially reprogrammed ones. All of these results will help improve the safety of PSCs in the clinical applications and increase the current low induction efficiency of their production.
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Taschenbuch. Condición: Neu. Neuware - This book provides a detailed description of photofunctionalization of molecular switch based on pyrimidine ring rotational isomerization in copper complexes bearing two bidentate ligands. The most important features of this work focus on the properties associated with the rotational isomer…ization based on the two possible coordination geometries at the copper center derived from two nitrogen atoms on the unsymmetrically substituted pyrimidine ring. The functions of systems such as dual emission and redox potential switching based on photo-driven rotation will be of particular interest to readers. Both the functions and the procedures for proving these phenomena are beneficial for the development of more functionalized systems based on material science, molecular science, nanoscience, nanotechnology, electrochemistry, photochemistry, coordination chemistry, physical chemistry, and related disciplines. The finding elucidated here holds promise for handling the photoprocesses of metal complexes, valid for both applications and novel properties. This system is expected make it possible to extract an electrochemical potential response from molecular switches, aiming to simulate the five senses of human beings at a single molecular level.
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Taschenbuch. Condición: Neu. Neuware - This book is in part a response to the attempts of governments to address increasing concerns over such environmental issues as the impact of climate change; carbon emissions; pressures from overpopulation of cities; coal seam gas extraction and depleting natural resources. The authors have… developed a Sustainable Communities Framework (SCF) which incorporates social-cultural, environmental and economic sustainability principles in the process of urban planning. The authors propose a five-step SCF built on an application of sustainability tables. The book examines a wide range of urban planning practices utilizing sustainability criteria, outlining both qualitative and quantitative tools. Separate chapters discuss application of the SCF to both the natural environment and the built environment. This framework is applied to a case study of the outer Sydney growth area of Wyong Shire, Central Coast, NSW, Australia. Addressing the question of how best to measure the environment, the authors present a table for selecting indicators of sustainability, and outline sustainability scorecards which use color-coded ratings of green, red and amber to measure indicators of sustainability. The authors show how aggregating these ratings allows the framework to be scaled up for application to larger areas. Finally, the authors show how scorecards can be incorporated in sustainability reports, with actions and monitoring components. The authors also examine urban planning education including land use planning, natural resource planning and sustainable urban planning, focusing on the extent to which schools incorporate principles of sustainability. The authors offer their critique on the movement of planning practices towards a more coordinated and holistic framework, in incorporating sustainability principles. Sustainable Communities: A Framework for Planning concludes by drawing a future scenario on the application of the SCF to incorporate principles of sustainability intourban planning. The authors propose future options for SCF applications, including adopting a systems program; environmental performance monitoring and showing how the framework will accommodate the social-cultural and economic components of sustainability, in addition to the environmental ones as examined in the case study.
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Taschenbuch. Condición: Neu. Neuware - This book introduces readers to classical population genetics and the ways in which it can be applied to practical problems, including testing for natural selection, genetic drift, genetic differentiation, population structuring, gene flow and linkage disequilibrium. It provides a comprehen…sive monograph on the topic, addressing the theory, applications and evolutionary deductions, which are clearly explained using experimental results. It also offers separate chapters on origin, establishment and spread of chromosomal aberrations in populations along with details of culturing, maintaining and using Drosophila ananassae (genetically unique and the most commonly used species along with D. melanogaster ) for genetic research. Encompassing topics like genetics, evolution, Drosophila genetics, population genetics, population structuring, natural selection and genetic drift in considerable detail, it provides a valuable resource to undergraduate and postgraduate students, as well as researchers at all level.This book explores some fundamental questions concerning the role of natural selection and genetic drift on the degree of inversion polymorphism. India, with its wide diversity in geo-climatic conditions, provides an excellent platform to conduct such studies. The book showcases sampling records of inversion frequencies in natural Indian populations of D. ananassae that cover more than two decades. It highlights case studies in which sampling data on inversion frequencies was combined with that from earlier surveys, generating a time series that allows the evolutionary dynamics of inversion polymorphism to be explored. Such long time series are rare but nonetheless crucial for studying the evolutionary dynamics of inversion polymorphism. The population-genetic analysis discussed is unprecedented in terms of its temporal (two decades) and spatial (most regions of India covered) scale and investigates the patterns of polymorphic system in D. ananassae to see if there is any temporal divergence. It endeavors to present a holistic picture of inversion polymorphism across the country (India).Chromosomal aberrations, particularly paracentric inversions, are used as a tool for discussing population genetic studies, helping human geneticists, gynecologists and other medical professionals understand why some aberrations are fatal in humans, with affected embryos often not surviving the first trimester of pregnancy, while similar aberrations in Drosophila flies aid in their adaptation to the environmental heterogeneity across the globe.
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Taschenbuch. Condición: Neu. Neuware - This fourteenth volume of the series provides comprehensive, current information on the diagnosis, therapy and prognosis of brain tumors and spinal tumors. For the readers' convenience, contributions are organized into three categories of Pineal Tumors, Pituitary Tumors, and Spinal Tumors.…Readers will find discussion of various aspects of a number of tumor types, including angiocentric glioma, pilomyxoid astrocytoma, pituicytoma, pediatric low-grade gliomas, meningiomas and spinal cord tumors. Expert oncologists, neurosurgeons, physicians, research scientists and pathologists from around the world have contributed to this extensive publication. Their chapters highlight practical experience and provide exceptional insight into the nature of cancer. The authors cover topics ranging from the use of molecular criteria in diagnosis and targeting of medicine, through evidence-based approaches, to in-depth discussion of long-term follow-up after surgery. This handbook, as earlier volumes in the series, will appeal to professionals involved in the treatment of cancer, as well as to researchers. The series crosses subjects of diagnosis, drug development, therapy and its assessment and prognosis of tumors of the central nervous system, cancer recurrence and resistance to chemotherapy.
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Taschenbuch. Condición: Neu. Neuware - This book gathers papers presented and discussions held at the Conference on Wind Energy and Wildlife Impacts in Melbourne, Australia on 9th October 2012. The purpose of the conference was to bring together researchers, industry, consultants, regulators and Non-Government Organizations to s…hare the results of studies into wind farm and wildlife investigations in Australia and New Zealand. The aim was to further networking and communication between these groups. The conference discussed key issues and areas for future investigation, with the intention of developing consistencies in research and management. Like the Conference, the book showcases current research and management in the field of wind farms and wildlife in Australia and New Zealand; establishes consistencies in research and management; and highlights areas in need of further examination. The papers in these Proceedings are presented in two session topics. The first covers 'Investigations and assessment of new wind farms' and the second, 'Monitoring, mitigation and offsets.'The Proceedings then summarize the panel discussions held at the end of the conference. The themes include improving pre- and post-construction survey design; identifying key knowledge gaps and research priorities; uncertainties and errors in data sets and analysis; creating opportunities to share knowledge; and assessing cumulative impacts across multiple sites.
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Taschenbuch. Condición: Neu. Neuware - Terricolous lichens, a habitat specialist group of lichens play a vital role in maintenance and ecological stability of soil crusts with reference to their physical stability, hydrology and growth of soil microflora. Terricolous lichens in Indian lichenological studies haven't been taken up… as a functional group. Terricolous Lichens in India, Volume 1: Diversity Patterns and Distribution Ecology is the first ever publication dealing with soil lichens of India. Divided into five chapters, this volume discusses the lichenological researches in India with reference to terricolous lichens, the altitudinal distribution patterns of terricolous lichens, comparative assessment of distribution with global patterns, and the photobiont diversity and influence of novel molecular clades of photobiont in determining ecological preferences of soil lichens in India. Written by experts in the field and supplemented with numerous photographs, Terricolous Lichens in India, Volume 1: Diversity Patterns and Distribution Ecology is a comprehensive resource that addresses the major drivers of terricolous lichens distribution in India.
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Taschenbuch. Condición: Neu. Neuware - This book covers the latest research work done in the area of interface mechanics of collagen and chitin-based biomaterials along with various techniques that can be used to understand mechanics of biological systems and materials. Topics covered include Raman spectroscopy of biological sys…tems, scale dependence of the mechanical properties and microstructure of crustaceans thin films as biomimetic materials, as well as the role of molecular-level modeling. The use of nanomechanics to investigate interface thermomechanics of collagen and chitin-based biomaterials is also covered in detail.This book also:-Details spectroscope experiments as well as nanomechanic experiments-Reviews exhaustively phenomenological models and Raman spectroscopy of biological systems-Covers the latest in multiscaling for molecular models to predict lab-scale sample properties and investigates interface thermomechanics.
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Taschenbuch. Condición: Neu. Neuware - This book brings to bear a body of logic synthesis techniques, in order to contribute to the analysis and control of Boolean Networks (BN) for modeling genetic diseases such as cancer. The authors provide several VLSI logic techniques to model the genetic disease behavior as a BN, with powe…rful implicit enumeration techniques. Coverage also includes techniques from VLSI testing to control a faulty BN, transforming its behavior to a healthy BN, potentially aiding in efforts to find the best candidates for treatment of genetic diseases.
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Taschenbuch. Condición: Neu. Neuware - This third volume in the series Tumor Dormancy, Quiescence, and Senescence discusses the role of tumor dormancy and senescence in a number of diseases, including breast cancer, ovarian cancer and leukemia. The contents are organized under five subheadings: General Applications, Role in Brea…st Cancer, Role in Ovarian Cancer, Role in Leukemia and Role in Cardiovascular Disease. The first section includes basic information on the definition of dormancy, how cells become senescent and what they do, along with an appraisal of the current state of research on dormancy. Section Two explores dormancy in breast cancer, including the progression of hormone-dependent mammary tumors after dormancy. Section Three details the resistance of Type II ovarian tumors, in which the resistant tumor cell population persists after chemotherapy in a state of dormancy, with recurrent tumors arising upon transformation of such dormant cells back to malignant growth. This section explains how lineage, histological subtypes and grade influence the differential response of ovarian cancer resistance to platinum drugs. The fourth section explores leukemia, discussing regulation of the promyelocytic leukemia protein and its role in premature senescence. The final section explores the role of senescence and autophagy in age-related cardiovascular diseases and the observation that autophagy seems to retard cardiac senescence. Like the two preceding volumes in the series, Volume 3 stands out for its comprehensive approach, its roster of some 26 expert contributors representing seven different countries and its up-to-date review of leading-edge technology and methods.
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Taschenbuch. Condición: Neu. Neuware - Using rodent models, this volume explores the basic neurobiology of the relationship among chronic pain, opioid pharmacology, and addiction.
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Editorial: Springer Nature B.V. Aug 2016, 2016
Serie: Libro 5 de 32 - Evolutionary Economics and Social Complexity Science
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Taschenbuch. Condición: Neu. Neuware - This book aims to discern and distinguish the essential features of basic economic theories and compare them with new theories that have arisen in recent years. The book focuses on seminal economic ideas and theories developed mainly in the 1930s to 1950s because their emergence eventually…led to new branches of economics. The book describes an alternative analytical framework spreading through the interdisciplinary fields of socioeconophysics and sociodynamics. The focus is on a set of branching or critical points that separate what has gone before from what has followed. W. Brian Arthur used the term 'redomaining' when he referred to technological innovation. In the present volume the author aims to re domain economic theories suited for a new social order. Major technological innovations accompany not only changes in the economy and the market but changes in their meaning as well. In particular, the evolution of trading technology has changed the meaning of the 'invisible hand.' At the end of the last century, the advent of socioeconophysics became a decisive factor in the emergence of a new economic science. This emergence has coincided with changes in the implications of the economy and the market, which consequently require a redomaining of economic science. In this new enterprise, the joint efforts of many scientists outside traditional economics have brought brilliant achievements such as power law distribution and network analysis, among others. However, the more diverse the backgrounds of economic scientists, the less integrated the common views among them may be, resulting in a sometimes perplexing potpourri of economic terminology. This book helps to mitigate those differences, shedding light on current alternative economic theories and how they have evolved.
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Editorial: Springer Nature B.V. Aug 2016, 2016
Serie: Libro 177 de 214 - Boston Studies in the Philosophy and History of Science
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Taschenbuch. Condición: Neu. Neuware - The present anthology, edited by Marcel Herbst, is partially based on a conference, held in 2009, to reflect on the legacy of Ben-David, and contains a selection of substantially revised papers, plus four contributions specifically written for this volume. The book focuses on three major li…nes of Ben-David's research, namely 'Center and Periphery' (Part I), 'Role and Ethos' (Part II), and 'Organization and Growth' (Part III). In addition, comprehensive introductory ('Prologue') and concluding chapters ('Epilogue', Part IV) by Marcel Herbst are provided. The volume addresses the following disciplines: higher education, history and sociology of science, philosophy of science, history of medicine, public administration, policy studies, Jewish studies, and economics. The anthology is one of two new publications on Joseph Ben-David after the special Minerva edition Vol. 25, Numbers 1-2, March 1987, and Gad Freudenthal's collection of Ben-David's writings [1991]. The text can be used in graduate studies, it addresses higher education professionals or public officials, and serves as a gateway to researchers in the field of higher education, science studies, or policy sciences.
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Taschenbuch. Condición: Neu. Neuware - Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contribute their insights on proteostasis maintenan…ce. The coverage mainly focuses on the basics of maintaining proteostasis, the consequences of proteostatic system failure, and how chaperone systems constantly maintain proteostasis. In addition, the book presents in detail different treatment strategies for diseases caused by proteostatic system failure, as well as the inhibition of proteostatic failure using small molecule compounds. It examines advances in the modulation of proteopathies, providing a comprehensive source of key mechanistic insights on these diseases. As such, the book offers a valuable resource for beginners and more experienced investigators alike who are looking for detailed and reliable information on protein homeostasis, the diseases that can develop due to related imbalances and the essential role of molecular and chemical chaperones.
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Taschenbuch. Condición: Neu. Neuware - This book aims to provide a complete overview of the diagnosis and treatment of gastrointestinal stromal tumors (GISTs). It has been conceived to be both a detailed guide for clinical practice and an updated reference for all those involved in the evaluation of GISTs imaging. The publicatio…n provides comprehensive descriptions of the full range of common imaging and non imaging techniques used in the diagnosis and followup of GISTs. Techniques reviewed include: Conventional radiography Endoscopy and endoscopic ultrasound Conventional, color-Doppler and contrast-enhanced ultrasound Computed tomography Magnetic resonance imaging, and Contrast-enhanced PET/CT imaging. Both medical and surgical treatment strategies are also fully reviewed. Finally, the book concludes with a chapter that aims to stimulate widespread interest in the formation of new GISTs Units. Written by experts in the field, the book is enriched throughout by numerous black-and-white and color images, making it an invaluable source of information as well as an indispensable guide to interpreting images for radiologists, gastroenterologists, pathologists, oncologists and surgeons.
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Taschenbuch. Condición: Neu. Neuware - Use of Microbes for the Alleviation of Soil Stresses, Volume 1 describes the most important details and advances related to the alleviation of soil stresses by soil microbes. Comprised of seven chapters, the book reviews the mechanisms by which plant growth promoting rhizobacteria (PGPR) al…leviate plant growth under stress; the role of mycorrhizal fungi on the alleviation of drought stress in host plants; how PGPR may alleviate salinity stress on the growth of host plants; and the role of PGPR on the growth of the host plant under the stress of sub optimal root zone temperature. Written by experts in their respective fields, Use of Microbes for the Alleviation of Soil Stresses, Volume 1 is a comprehensive and valuable resource for researchers and students interested in the field of microbiology and soil stresses.
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Taschenbuch. Condición: Neu. Neuware - Based on 30 years of clinical and research experience, backed by a careful assessment of four decades of published data, Dr. Faguet documented in The War on Cancer (Springer 2005), early advances in cancer treatment and patient survival that soon stalled. Ten years later and after an exhaus…tive analysis of evidence-based data available through 2013 that incorporates 755 references, he reveals the root causes of the stagnation in cancer control, including the role played by major stakeholders and advocates a coordinated national effort, akin to the Apollo program, to unveil the causes of cancer and their mastery. In the interim, Dr. Faguet urges caregivers to manage patients according to the four ethical principles of beneficence, non-maleficence, respect for patients' autonomy and justice especially at the end of life.
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Idioma: Inglés
Editorial: Springer Nature B.V. Aug 2016, 2016
Serie: Libro 1 de 51 - Advances in Geographical and Environmental Sciences
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Taschenbuch. Condición: Neu. Neuware - This book identifies and analyzes livelihood impacts of recent environmental and socio-economic changes in urban and rural settings of the mountainous state of Himachal Pradesh, north western Himalaya, India. The findings of the research deal with the broader objectives of the changing patt…erns of agricultural production with special reference to diversification, as well as forest-based livelihood outcomes, Clean Development Mechanism forest project activities, the roles of different ethnic groups and non-governmental organizations and the benefits and shortcomings of tourism as a livelihood source. These tasks are studied by using an exploratory approach, with participant observation, interviews through random and cluster sampling among villagers, local land users and officials, as well as with land cover interpretation and secondary statistical data. This book is relevant for educational use together with policy input on the issues exploring livelihood security in a rapidly growing developing country.
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Editorial: Springer Nature B.V. Aug 2016, 2016
Serie: Libro 76 de 176 - Springer Optimization and Its Applications
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Taschenbuch. Condición: Neu. Neuware - This volume contains a collection of papers based on lectures and presentations delivered at the International Conference on Constructive Nonsmooth Analysis (CNSA) held in St. Petersburg (Russia) from June 18-23, 2012. This conference was organized to mark the 50th anniversary of the birth…of nonsmooth analysis and nondifferentiable optimization and was dedicated to J.-J. Moreau and the late B.N. Pshenichnyi, A.M. Rubinov, and N.Z. Shor, whose contributions to NSA and NDO remain invaluable.The first four chapters of the book are devoted to the theory of nonsmooth analysis. Chapters 5-8 contain new results in nonsmooth mechanics and calculus of variations. Chapters 9-13 are related to nondifferentiable optimization, and the volume concludes with four chapters containing interesting and important historical chapters, including tributes to three giants of nonsmooth analysis, convexity, and optimization: Alexandr Alexandrov, Leonid Kantorovich, and Alex Rubinov. The last chapter provides an overview and important snapshots of the 50-year history of convex analysis and optimization.
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Editorial: Springer Nature B.V. Aug 2016, 2016
Serie: Libro 142 de 464 - Springer Proceedings in Mathematics & Statistics
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Taschenbuch. Condición: Neu. Neuware - The book is based on research presentations at the international conference, 'Emerging Trends in Applied Mathematics: In the Memory of Sir Asutosh Mookerjee, S.N. Bose, M.N. Saha and N.R. Sen', held at the Department of Applied Mathematics, University of Calcutta, during 12-14 February 2014…. It focuses on various emerging and challenging topics in the field of applied mathematics and theoretical physics. The book will be a valuable resource for postgraduate students at higher levels and researchers in applied mathematics and theoretical physics.Researchers presented a wide variety of themes in applied mathematics and theoretical physics-such as emergent periodicity in a field of chaos; Ricci flow equation and Poincare conjecture; Bose-Einstein condensation; geometry of local scale invariance and turbulence; statistical mechanics of human resource allocation: mathematical modelling of job-matching in labour markets; contact problem in elasticity; the Saha equation; computational fluid dynamics with applications in aerospace problems; an introduction to data assimilation, stochastic analysis and bounds on noise for Holling type-II model, graph theoretical invariants of chemical and biological systems; strongly correlated phases and quantum phase transitions of ultra cold bosons; and the mathematical modelling of breast cancer treatment.
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Taschenbuch. Condición: Neu. Neuware - GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed 'tonic' inhibition, has been described. Whereas synaptic GABAA receptors underlie classical 'phasic' GABAA receptor-media…ted inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.
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Serie: Libro 84 de 176 - Springer Optimization and Its Applications
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Taschenbuch. Condición: Neu. Neuware - The volume is dedicated to Boris Mirkin on the occasion of his 70th birthday. In addition to his startling PhD results in abstract automata theory, Mirkin's ground breaking contributions in various fields of decision making and data analysis have marked the fourth quarter of the 20th centur…y and beyond. Mirkin has done pioneering work in group choice, clustering, data mining and knowledge discovery aimed at finding and describing non-trivial or hidden structures-first of all, clusters, orderings and hierarchies-in multivariate and/or network data.This volume contains a collection of papers reflecting recent developments rooted in Mirkin's fundamental contribution to the state-of-the-art in group choice, ordering, clustering, data mining and knowledge discovery. Researchers, students and software engineers will benefit from new knowledge discovery techniques and application directions.
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Taschenbuch. Condición: Neu. Neuware - The purpose of this Gazetteer and Atlas of Astronomy (GAA) is to list, define and illustrate, for the first time, every named (as opposed to merely catalogued) object in the sky within a single reference work for use by the general reader, writers and editors dealing with astronomical theme…s, and those astronomers concerned with any aspect of astronomical nomenclature. Each part of the GAA will contain: - An introduction to the nomenclature of the body or group of bodies in question - A glossary of terminology used - A gazetteer listing in strict alphanumerical sequence essential information defining the body or feature concerned - An alphanumerically arranged classified index of all the headwords in the gazetteer - An atlas comprising maps and images with coordinate grids and labels identifying features listed in the gazetteer - Appendix material on the IAU nomenclature system and the transcription systems used for non-roman alphabets.
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Taschenbuch. Condición: Neu. Neuware - Rapid advances in molecular medicine have led to pronounced new developments in experimental and clinical cardiology. In the embrace of modern molecular biology and bridging the gap between the clinical and the genomic, cardiovascular medicine has seen major strides in the understanding of…the molecular mechanisms that drive disease progression. The ability to rapidly identify candidate human genes for cardiovascular diseases lends itself to the development of diverse strategies for disease treatment and management. The wide variety of gene expressions proffers excellent targets for novel therapeutics. Gene therapy is steadily increasing in viability and represents a fascinating arena of research and clinical focus. This book is based on two international Mendel symposia on 'Genes and the Heart,' joint meetings of the Japanese and European sections of the International Academy of Cardiovascular Sciences. Highlighting selected symposia contributions, this book explores the role of molecular biology and genetics in the basic knowledge, genesis, and clinical interventions of cardiovascular diseases.
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Taschenbuch. Condición: Neu. Neuware - This book reports the text of the lectures of the 6th International Conference on Sodium Calcium Exchange held in Lacco Ameno in the Island of Ischia in the Gulf of Naples, Italy, from October 1 to October 5, 2011. The present book uncovers the most striking new findings on NCX that emerged… since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the molecular determinants of Ca2+ sensitivity of the exchanger, the epigenetic regulation of ncx1 gene, the molecular identification of the mitochondrial Sodium Calcium Exchanger, and the discovery of NCX in unexpected anatomical locations such as the female reproductive tract.The book is organized into 11 parts covering NCX structural aspects, genetic and epigenetic regulation, regulatory mechanisms, subcellular localization in mitochondria, involvement in neurodegenerative diseases and in immune regulation, and the role of the cardiovascular and endocrine systems, as well as diabetes in physiology and pathophysiology. Selected chapters of the book are also devoted to the interaction of NCKX and other ion channels and transporters with NCX, like ASICs, TRPM, and NHE.
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Taschenbuch. Condición: Neu. Neuware - In recent years, a new understanding of cell-penetrating peptides has emerged, helping researchers to expand beyond a number of long-held dogmas. In Cell-Penetrating Peptides: Methods and Protocols, expert researchers explore the latest information on cell-penetrating peptides (CPPs), provi…ding insight into the most important and contemporary areas of CPP research. Chapters address the historical background of CPP studies, provide an overview of the growing field of research, investigate methods for testing CPP mechanisms, present a summary of methods that attempt to use properties of CPPs to study biochemical intracellular mechanisms of interaction and signal transduction, and include new ideas for turning CPP-based strategies into drugs. Composed in the highly successful Methods in Molecular Biology(TM) series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.Innovative and current, Cell-Penetrating Peptides: Methods and Protocols is an essential guide that allows researchers to study intracellular mechanisms in new ways, and to promote the future development of novel drugs.
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Taschenbuch. Condición: Neu. Neuware - Nutrition in Pediatric Pulmonary Disease is a much needed resource for practitioners that provides a basic understanding of nutrition and nutritional supplements; their impact on physiologic function and how this can be applied for general health maintenance as well as a supplemental treatm…ent for pulmonary diseases. This book provides information on (1) basics of nutrition, supplements and herbs and how they influence physiology (2) their application and potential use for various pulmonary diseases along with evidence regarding efficacy and safety. Also examined are (3) how diet, dietary supplements and herbs are integrated together for treatment and prevention of pulmonary disease. Finally (4) several health promoting diets and their potential benefits to patients with pulmonary diseases will be discussed. Nutrition in Pediatric Pulmonary Disease is an excellent new resource for practicing physicians who are interested in incorporating more nutritional approaches to treating their patients.
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Taschenbuch. Condición: Neu. Neuware - As the number of patients with colitis-associated cancer (CAC) is on the increase, the purpose of this book is to review the latest topics concerning management of the disease. In recent years, the diagnostic power of endoscopy and molecular pathology has also grown tremendously, as a resul…t of which they now have a far greater influence on the treatment of CAC. At the moment, appropriate monitoring programs for ulcerative colitis and Crohn's disease remain uncertain. At the same time, the latest findings on DNA methylation and microRNAs hold the promise of making revolutionary changes in these areas. Moreover, recent drug advances in the treatment of inflammatory bowel diseases have changed surgical indications. On the other hand, the indication of mucosectomy on colorectal cancer in ulcerative colitis and prophylactic abdominoperineal resection for Crohn's disease remain controversial. This book provides the latest information on the remaining issues of CAC from the point of view of expert surgeons.
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Taschenbuch. Condición: Neu. Neuware - Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia provides a comprehensive understanding of the recent molecular genetics of Chronic Myelogenous Leukemia (CML) and a characterization of the molecular targets for drug development. Included are therapeutic implications, dia…gnosis, and prognosis for understanding and facilitating daily practice in the management of patients with CML.Understanding of the pathogenesis and therapy of hematological malignancies such as CML has grown significantly in recent years. This development owe much to the progress in molecular biology and now makes a major contribution to diagnosis and to treatment that pharmacologically targets the molecular events of CML. Molecular targeting therapy with newly developed agents such as small molecules and antibodies for hematological malignancies are being discovered after years of research. Some of these, including tyrosine kinase inhibitors such as imatinib, nilotinib, and dasatinib, lead to increased survival rates and improved therapies. With the opinion leaders of basic and clinical research in the field as authors, this book reviews recent advances in the biology of CML.
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Idioma: Inglés
Editorial: Springer Nature B.V. Aug 2016, 2016
Serie: Libro 1 de 15 - Current Topics in Environmental Health and Preventive Medicine
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Taschenbuch. Condición: Neu. Neuware - This volume examines our current understanding of the biological effects of fibrous and particulate substances, including discussions on nanoparticles. It offers comprehensive information on the latest insights into the immunological effects of various irritants on the human body. Readers w…ill benefit from the contributing authors' diverse perspectives and extensive discussions of key issues, which include molecular alterations of the immune system and autoimmune diseases in connection with asbestos and silica, among others. The chapters also discuss recommendations, practical methods, and nanosafety science in situations involving exposure to nanotoxic substances. Edited in collaboration with the Japanese Society for Hygiene, this book provides up-to-date information on the immunological effects of nanotoxic substances to researchers interested in environmental and occupational health. Presenting a number of recent concepts and findings in the field, it enables readers to gain a comprehensive knowledge of health problems caused by environmental fibrous and particulate substances.
