springer london sep 2016 (105 resultados)

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Energy is becoming a prominent driver of economic development. Each year, billions of dollars are invested around the world by the public and private sectors in low-emissions energy development and energy efficiency planning. Energy-based economic development (EBED) is a domain that seizes the opportunities inherent in clean energy development to drive innovation and generate economic growth. Energy-based economic development: How clean energy can drive development and stimulate economic growth delivers working definitions, common approaches, descriptions of supportive policy mechanisms, and suggested metrics for evaluation. The book offers a unified framework for EBED that is supported by examples and leaves readers better equipped to design, plan, and implement EBED initiatives. Case studies illustrate how national and subnational initiatives adopt to a locale's energy asset base, energy and economic development needs, and the context in which the initiative operates. Descriptions of the energy projects supported by the American Recovery and Reinvestment Act offer insights about what worked and what did not and suggest ways in which governments can be better prepared to manage EBED projects in the future. This book provides the tools necessary to work toward simultaneous energy and economic development goals and facilitates discussion for an advanced policy agenda of energy efficiency, energy diversification, innovation-led economic growth, and job creation. 180 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Integrative and translational methodologies and frameworks have transformed modern biomedical research and the delivery of clinical care. This shift has been manifested in a number of ways, including the rapid growth and increasing availability of high-throughput bio-molecular instrumentation and analysis platforms, innovative clinical research programs intended to accelerate knowledge translation, and initial efforts to deliver personalized healthcare informed by the genomic profiles of patients. A common theme of reports and publications concerned with such transformative changes in the biomedical and healthcare domains is concerned with the challenges and opportunities related to the collection, management, integration, analysis, and dissemination of large-scale, heterogeneous biomedical data sets. In particular, the absence of well-established and adopted theoretical and practical frameworks intended to address such needs is a major impediment to the realization of translational and knowledge-driven healthcare, in which the best possible scientific evidence is used to inform the care of every patient. In this vacuum, the development of integrative clinical or translational research paradigms is significantly limited by the propagation of both data and expertise silos. This book details for the first time the current state of this extremely potent area of healthcare innovation and policy and defines the interaction between clinical/translational science and biomedical informatics. 196 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book addresses the challenges of data abstraction generation using a least number of database scans, compressing data through novel lossy and non-lossy schemes, and carrying out clustering and classification directly in the compressed domain. Schemes are presented which are shown to be efficient both in terms of space and time, while simultaneously providing the same or better classification accuracy. Features: describes a non-lossy compression scheme based on run-length encoding of patterns with binary valued features; proposes a lossy compression scheme that recognizes a pattern as a sequence of features and identifying subsequences; examines whether the identification of prototypes and features can be achieved simultaneously through lossy compression and efficient clustering; discusses ways to make use of domain knowledge in generating abstraction; reviews optimal prototype selection using genetic algorithms; suggests possible ways of dealing with big data problems using multiagent systems. 216 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Although the area of International Manufacturing Network (IMN) and International Operations Network (ION) has received considerable attention in the literature, most of studies appear multifaceted and interdisciplinary, and thereby require thorough investigation from both academic and practical perspectives, in order to deepen our related understanding. The book seeks advanced contributions that will combine theoretical insights and empirical experience by offering a detailed examination of IMN and, further, ION from various perspectives. This book can be used as a reference material for scholar-practitioners, business executives, and university researchers who need to deepen their understanding on the importance and influence of IMN and ION as well as their development. The book is important because there are few reference/resource materials available related to IMN and ION. 192 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This revised edition covers all aspects of public health informatics and discusses the creation and management of an information technology infrastructure that is essential in linking state and local organizations in their efforts to gather data for the surveillance and prevention. Public health officials will have to understand basic principles of information resource management in order to make the appropriate technology choices that will guide the future of their organizations. Public health continues to be at the forefront of modern medicine, given the importance of implementing a population-based health approach and to addressing chronic health conditions. This book provides informatics principles and examples of practice in a public health context. In doing so, it clarifies the ways in which newer information technologies will improve individual and community health status. This book's primary purpose is to consolidate key information and promote a strategic approach to information systems and development, making it a resource for use by faculty and students of public health, as well as the practicing public health professional. Chapter highlights include: The Governmental and Legislative Context of Informatics; Assessing the Value of Information Systems; Ethics, Information Technology, and Public Health; and Privacy, Confidentiality, and Security. Review questions are featured at the end of every chapter. Aside from its use for public health professionals, the book will be used by schools of public health, clinical and public health nurses and students, schools of social work, allied health, and environmental sciences. 684 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -'Entertainment media' are entertainment products and services that rely on digital technology and include traditional media (such as movies, TV, computer animation etc) as well as emerging services for wireless and broadband, electronic toys, video games, edutainment, and location-based entertainment (from PC game rooms to theme parks).Whilst most of the digital entertainment industry is found in the developed countries such as USA, Europe, and Japan, the decreasing costs of computer and programming technologies enables developing countries to really benefit from entertainment media in two ways: as creators and producers of games and entertainment for the global market and as a way to increase creativity and learning among the youth of the developing world.Focusing specifically on initiatives that use entertainment technologies to promote economic development, education, creativity and cultural dissemination, this book explores how current technology and the use of off-the-shelf technologies (such as cheap sensors, Kinect, Arduino and others) can be exploited to achieve more innovative and affordable ways to harness the entertainment power of creating. It poses questions such as 'How can we convert consumers of entertainment into creators of entertainment ' 'How can digital entertainment make a contribution to the emerging world '.Academic researchers and students in human-computer interaction, entertainment computing, learning technologies will find the content thought-provoking, and companies and professionals in game and entertainment technology, mobile applications, social networking etc. will find this a valuable resource in developing new products and new markets. 164 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book presents a world-class collection of Brain-Computer Music Interfacing (BCMI) tools. The text focuses on how these tools enable the extraction of meaningful control information from brain signals, and discusses how to design effective generative music techniques that respond to this information. Features: reviews important techniques for hands-free interaction with computers, including event-related potentials with P300 waves; explores questions of semiotic brain-computer interfacing (BCI), and the use of machine learning to dig into relationships among music and emotions; offers tutorials on signal extraction, brain electric fields, passive BCI, and applications for genetic algorithms, along with historical surveys; describes how BCMI research advocates the importance of better scientific understanding of the brain for its potential impact on musical creativity; presents broad coverage of this emerging, interdisciplinary area, from hard-core EEG analysis to practical musical applications. 332 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This edited collection will provide an overview of the field of physiological computing, i.e. the use of physiological signals as input for computer control. It will cover a breadth of current research, from brain-computer interfaces to telemedicine. 256 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The book adopts an innovative analytical approach to agenda setting by not only presenting successful cases in which energy issues were addressed by means of public policy, but by also analyzing failed attempts to make issues part of the European policy agenda. Another outstanding feature of the book is its use of the latest empirical data on a broad range of energy issues.When are energy issues likely to find their way to the agenda of European policymakers This is the key research question guiding this collection of empirical studies, which will shed light on both successful and unsuccessful attempts to include energy issues in the European agenda. The multi-level political system of the European Union represents a particularly fruitful setting for addressing this question due to the multiple institutional access points it provides for different groups of actors. The book has three key benefits. First, it provides a theory-informed analysis of agenda setting processes in general and in the European Union in particular. Second, it presents an overview of the most important and emerging dimensions on European energy policy, and third, it helps to develop a research agenda for future research in the field. 276 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The featured review of the AMS describes the author's earlier work in the field of approach spaces as, 'A landmark in the history of general topology'. In this book, the author has expanded this study further and taken it in a new and exciting direction.The number of conceptually and technically different systems which characterize approach spaces is increased and moreover their uniform counterpart, uniform gauge spaces, is put into the picture. An extensive study of completions, both for approach spaces and for uniform gauge spaces, as well as compactifications for approach spaces is performed. A paradigm shift is created by the new concept of index analysis.Making use of the rich intrinsic quantitative information present in approach structures, a technique is developed whereby indices are defined that measure the extent to which properties hold, and theorems become inequalities involving indices; therefore vastly extending the realm of applicability of many classical results. The theory is then illustrated in such varied fields as topology, functional analysis, probability theory, hyperspace theory and domain theory. Finally a comprehensive analysis is made concerning the categorical aspects of the theory and its links with other topological categories.Index Analysis will be useful for mathematicians working in category theory, topology, probability and statistics, functional analysis, and theoretical computer science. 488 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Offers a unique multidisciplinary overview of how humans interact with soft objects and how multiple sensory signals are used to perceive material properties, with an emphasis on object deformability. The authors describe a range of setups that have been employed to study and exploit sensory signals involved in interactions with compliant objects as well as techniques to simulate and modulate softness - including a psychophysical perspective of the field.Multisensory Softness focuses on the cognitive mechanisms underlying the use of multiple sources of information in softness perception. Divided into three sections, the first Perceptual Softness deals with the sensory components and computational requirements of softness perception, the second Sensorimotor Softness looks at the motor components of the interaction with soft objects and the final part Artificial Softness focuses on the identification of exploitable guidelines to help replicate softness in artificial environments. 272 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book presents a systematic introduction to the latest developments in video text detection. Opening with a discussion of the underlying theory and a brief history of video text detection, the text proceeds to cover pre-processing and post-processing techniques, character segmentation and recognition, identification of non-English scripts, techniques for multi-modal analysis and performance evaluation. The detection of text from both natural video scenes and artificially inserted captions is examined. Various applications of the technology are also reviewed, from license plate recognition and road navigation assistance, to sports analysis and video advertising systems. Features: explains the fundamental theory in a succinct manner, supplemented with references for further reading; highlights practical techniques to help the reader understand and develop their own video text detection systems and applications; serves as an easy-to-navigate reference, presenting the material in self-contained chapters. 276 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book captures the state of the art in cloud technologies, infrastructures, and service delivery and deployment models. The work provides guidance and case studies on the development of cloud-based services and infrastructures from an international selection of expert researchers and practitioners. Features: presents a focus on security and access control mechanisms for cloud environments, analyses standards and brokerage services, and investigates the role of certification for cloud adoption; evaluates cloud ERP, suggests a framework for implementing 'big data' science, and proposes an approach for cloud interoperability; reviews existing elasticity management solutions, discusses the relationship between cloud management and governance, and describes the development of a cloud service capability assessment model; examines cloud applications in higher education, including the use of knowledge-as-a-service in the provision of education, and cloud-based e-learning for students with disabilities. 432 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 360 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book will present completely new, unique findings in eczema: sweat ducts that become occluded with staphylococcal biofilms trigger the innate immune system with TLR2 receptor activity and this leads to production of the 'itching' and inflammation in this disease. Dermatologists and pediatricians treat eczema exceedingly well and this is ordinarily accomplished with corticosteroid containing topicals. However, after treatment, it is intriguing that aggressive moisturization and cautious bathing will in most instances prevent future flares of the disease, even though it is precipitated by bacteria and their biofilms. Diseases where eczema has been found with a completely unrelated disorder have shown occluded sweat ducts on histopathologic examination. These include Meyerson's nevus which has a nevus and eczema in the same biopsy and Doucas Kapetanakis-type of pigmented purpuric dermatosis that shows occluded sweat ducts along with the capillaritis. 136 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Hypertension remains the leading cause of cardiovascular morbidity and mortality in spite of current medical therapies. It has been estimated that 50% of Western civilization has hypertension and approximately 20% of patients have resistant hypertension. Renal denervation (RDN) is a minimally invasive, endovascular catheter based procedure using radiofrequency ablation aimed at treating resistant hypertension. Early studies show a high degree of effectiveness in renal denervation to treat hypertension.This book examines renal pathophysiology and the rationale for renal denervation, as well as possible long term benefits and risks of this new therapy. The myriad of devices involved in the evolution of this therapy are discussed and the book concludes with analyses of the cost effectiveness and future applications. 216 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The practice of modern medicine and biomedical research requires sophisticated information technologies with which to manage patient information, plan diagnostic procedures, interpret laboratory results, and carry out investigations. Biomedical Informatics provides both a conceptual framework and a practical inspiration for this swiftly emerging scientific discipline at the intersection of computer science, decision science, information science, cognitive science, and biomedicine. Now revised and in its third edition, this text meets the growing demand by practitioners, researchers, and students for a comprehensive introduction to key topics in the field. Authored by leaders in medical informatics and extensively tested in their courses, the chapters in this volume constitute an effective textbook for students of medical informatics and its areas of application. The book is also a useful reference work for individual readers needing to understand the role that computers can play in the provision of clinical services and the pursuit of biological questions. The volume is organized so as first to explain basic concepts and then to illustrate them with specific systems and technologies. 992 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Hacking Europe traces the user practices of chopping games in Warsaw, hacking software in Athens, creating chaos in Hamburg, producing demos in Turku, and partying with computing in Zagreb and Amsterdam. Focusing on several European countries at the end of the Cold War, the book shows the digital development was not an exclusively American affair. Local hacker communities appropriated the computer and forged new cultures around it like the hackers in Yugoslavia, Poland and Finland, who showed off their tricks and creating distinct 'demoscenes.' Together the essays reflect a diverse palette of cultural practices by which European users domesticated computer technologies. Each chapter explores the mediating actors instrumental in introducing and spreading the cultures of computing around Europe. More generally, the 'ludological' element--the role of mischief, humor, and play--discussed here as crucial for analysis of hacker culture, opens new vistas for the study of the history of technology. 280 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Disorders of the Hand describes the techniques for diagnosis applicable to the various disorders of the hand and how evidence based findings influence clinical practice. Treatment options including surgery are discussed in detail and clinical pearls are given in every chapter. Nerve compression and hand reconstruction are comprehensively covered in this second of four volumes, while hand injuries, inflammation and arthritis, swelling and tumours, congenital hand defects and surgical techniques are included in the book's three sister volumes. 316 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Presenting the first definitive study of the subject, this Handbook of Biometric Anti-Spoofing reviews the state of the art in covert attacks against biometric systems and in deriving countermeasures to these attacks. Topics and features: provides a detailed introduction to the field of biometric anti-spoofing and a thorough review of the associated literature; examines spoofing attacks against five biometric modalities, namely, fingerprints, face, iris, speaker and gait; discusses anti-spoofing measures for multi-model biometric systems; reviews evaluation methodologies, international standards and legal and ethical issues; describes current challenges and suggests directions for future research; presents the latest work from a global selection of experts in the field, including members of the TABULA RASA project. 300 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Discrete Control Systems establishes a basis for the analysis and design of discretized/quantized control systems for continuous physical systems. Beginning with the necessary mathematical foundations and system-model descriptions, the text moves on to derive a robust stability condition. To keep a practical perspective on the uncertain physical systems considered, most of the methods treated are carried out in the frequency domain.As part of the design procedure, modified Nyquist-Hall and Nichols diagrams are presented and discretized proportional-integral-derivative control schemes are reconsidered. Schemes for model-reference feedback and discrete-type observers are proposed. Although single-loop feedback systems form the core of the text, some consideration is given to multiple loops and nonlinearities. The robust control performance and stability of interval systems (with multiple uncertainties) are outlined.Finally, the monograph describes the relationship between feedback-control and discrete event systems. The nonlinear phenomena associated with practically important event-driven systems are elucidated. The dynamics and stability of finite-state and discrete-event systems are defined.Academic researchers interested in the uses of discrete modelling and control of continuous systems will find Discrete Control Systems instructive. The inclusion of end-of-chapter problems also makes the book suitable for use in self study either by professional control engineers or graduate students supplementing a more formal regimen of learning. 264 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This monograph focuses on characterizing the stability and performance consequences of inserting limited-capacity communication networks within a control loop. The text shows how integration of the ideas of control and estimation with those of communication and information theory can be used to provide important insights concerning several fundamental problems such as: minimum data rate for stabilization of linear systems over noisy channels; minimum network requirement for stabilization of linear systems over fading channels; and stability of Kalman filtering with intermittent observations.A fundamental link is revealed between the topological entropy of linear dynamical systems and the capacities of communication channels. The design of a logarithmic quantizer for the stabilization of linear systems under various network environments is also extensively discussed and solutions to many problems of Kalman filtering with intermittent observations are demonstrated.Analysis and Design of Networked Control Systems will interest control theorists and engineers working with networked systems and may also be used as a resource for graduate students with backgrounds in applied mathematics, communications or control who are studying such systems. 336 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This authoritative text/reference presents a review of the history, current status, and potential future directions of computational biology in molecular evolution. Gathering together the unique insights of an international selection of prestigious researchers, this must-read volume examines the latest developments in the field, the challenges that remain, and the new avenues emerging from the growing influx of sequence data. These viewpoints build upon the pioneering work of David Sankoff, one of the founding fathers of computational biology, and mark the 50 th anniversary of his first scientific article. The broad spectrum of rich contributions in this essential collection will appeal to all computer scientists, mathematicians and biologists involved in comparative genomics, phylogenetics and related areas. 340 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Mathematical algorithms are a fundamental component of Computer Aided Design and Manufacturing (CAD/CAM) systems. This book provides a bridge between algebraic geometry and geometric modelling algorithms, formulated within a computer science framework.Apart from the algebraic geometry topics covered, the entire book is based on the unifying concept of using algebraic techniques - properly specialized to solve geometric problems - to seriously improve accuracy, robustness and efficiency of CAD-systems. It provides new approaches as well as industrial applications to deform surfaces when animating virtual characters, to automatically compare images of handwritten signatures and to improve control of NC machines.This book further introduces a noteworthy representation based on 2D contours, which is essential to model the metal sheet in industrial processes. It additionally reviews applications of numerical algebraic geometry to differential equations systems with multiple solutions and bifurcations.Future Vision and Trends on Shapes, Geometry and Algebra is aimed specialists in the area of mathematics and computer science on the one hand and on the other hand at those who want to become familiar with the practical application of algebraic geometry and geometric modelling such as students, researchers and doctorates. 172 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Based on the seminar that took place in Dagstuhl, Germany in June 2011, this contributed volume studies the four important topics within the scientific visualization field: uncertainty visualization, multifield visualization, biomedical visualization and scalable visualization. - Uncertainty visualization deals with uncertain data from simulations or sampled data, uncertainty due to the mathematical processes operating on the data, and uncertainty in the visual representation,- Multifield visualization addresses the need to depict multiple data at individual locations and the combination of multiple datasets,- Biomedical is a vast field with select subtopics addressed from scanning methodologies to structural applications to biological applications,- Scalability in scientific visualization is critical as data grows and computational devices range from hand-held mobile devices to exascale computational platforms.Scientific Visualization will be useful to practitioners of scientific visualization, students interested in both overview and advanced topics, and those interested in knowing more about the visualization process. 420 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This accessible text/reference presents a coherent overview of the emerging field of non-Euclidean similarity learning. The book presents a broad range of perspectives on similarity-based pattern analysis and recognition methods, from purely theoretical challenges to practical, real-world applications. The coverage includes both supervised and unsupervised learning paradigms, as well as generative and discriminative models. Topics and features: explores the origination and causes of non-Euclidean (dis)similarity measures, and how they influence the performance of traditional classification algorithms; reviews similarity measures for non-vectorial data, considering both a 'kernel tailoring' approach and a strategy for learning similarities directly from training data; describes various methods for 'structure-preserving' embeddings of structured data; formulates classical pattern recognition problems from a purely game-theoretic perspective; examines two large-scale biomedical imaging applications. 308 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book provides a manual for the technical and structural design of systems for supplying decentralised energy in residential buildings. It presents the micro-combined cooling, heating & power systems Stirling engines & renewable energy sources (mCCHP-SE-RES) systems in an accessible manner both for the public at large, and for professionals who conceive, design or commercialise such systems or their components. The high performance levels of these systems are demonstrated within the final chapter by the results of an experiment in which a house is equipped with a mCCHP-SE-RES system. The reader is also familiarized with the conceptual, technical and legal aspects of modern domestic energy systems; the components that constitute these systems; and advanced algorithms for achieving the structural and technical design of such systems.In residential buildings, satisfying demands of durable development has gradually evolved from necessity to obligation and institutionalisation. Consequently a major paradigm change has appeared in the supply of energy to residential buildings, from the centralised production of energy using fossil fuels to the decentralised production of energy using local renewable sources. Furthermore, on the energy system market, energy micro systems which use renewable energy sources are increasingly commercialised. From among these, the mCCHP-SE-RES systems are particularly striking because they offer a high performance and they enhance the relationship between humans and the environment. This book is intended for postgraduate students of electrical engineering, applied mathematicians, and researchers of modelling and control of complex systems or power system technologies. 404 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Providing a comprehensive introduction into an overview of the field of pervasive healthcare applications, this volume incorporates a variety of timely topics ranging from medical sensors and hardware infrastructures, to software platforms and applications and addresses issues of user experience and technology acceptance.The recent developments in the area of information and communication technologies have laid the groundwork for new patient-centred healthcare solutions. While the majority of computer-supported healthcare tools designed in the last decades focused mainly on supporting care-givers and medical personnel, this trend changed with the introduction of pervasive healthcare technologies, which provide supportive and adaptive services for a broad variety and diverse set of end users.With contributions from key researchers the book integrates the various aspects of pervasive healthcare systems including application design, hardware development, system implementation, hardware and software infrastructures as well as end-user aspects providing an excellent overview of this important and evolving field. 380 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book provides a comprehensive overview of metabonomics and gut microbiota research from molecular analysis to population-based global health considerations. The topics include the discussion of the applications in relation to metabonomics and gut microbiota in nutritional research, in health and disease and a review of future therapeutical, nutraceutical and clinical applications. It also examines the translatability of systems biology approaches into applied clinical research and to patient health and nutrition.The rise in multifactorial disorders, the lack of understanding of the molecular processes at play and the needs for disease prediction in asymptomatic conditions are some of the many questions that system biology approaches are well suited to address. Achieving this goal lies in our ability to model and understand the complex web of interactions between genetics, metabolism, environmental factors and gut microbiota. Being the most densely populated microbial ecosystem on earth, gut microbiota co-evolved as a key component of human biology, essentially extending the physiological definition of humans.Major advances in microbiome research have shown that the contribution of the intestinal microbiota to the overall health status of the host has been so far underestimated. Human host gut microbial interaction is one of the most significant human health considerations of the present day with relevance for both prevention of disease via microbiota-oriented environmental protection as well as strategies for new therapeutic approaches using microbiota as targets and/or biomarkers. In many aspects, humans are not a complete and fully healthy organism without their appropriate microbiological components. Increasingly, scientific evidence identifies gut microbiota as a key biological interface between human genetics and environmental conditions encompassing nutrition. Microbiota dysbiosis or variation in metabolic activity has been associated with metabolic deregulation (e.g. obesity, inflammatory bowel disease), disease risk factor (e.g. coronary heart disease) and even the aetiology of various pathologies (e.g. autism, cancer), although causal role into impaired metabolism still needs to be established.Metabonomics and Gut Microbiota in Nutrition and Disease serves as a handbook for postgraduate students, researchers in life sciences or health sciences, scientists in academic and industrial environments working in application areas as diverse as health, disease, nutrition, microbial research and human clinical medicine. 400 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin secretion are fundamental to the pathogenesis and progression of obesity-associated type 2 diabetes. There is a need to explain how new drugs can counter insulin resistance and insulin deficiency to a broad range of professionals, from clinical scientists active in early (and later) phase drug development to specialist physicians and increasingly primary care doctors who must tailor drug regimens to the individual patient. Clinical research methods for measuring insulin action and insulin secretion have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. The purpose of the book is to aid the selection of the most appropriate techniques for assessing insulin action, insulin secretion and body composition in humans (with particular reference to new drugs) in phase 1 and 2 studies and aid the understanding of drug effects and non-drug treatment strategies on key biochemical-hormonal defects of obesity and type 2 diabetes. The book will assume a working knowledge of human physiology relating to glucose metabolism and will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties. 324 pp. Englisch.