springer basel springer basel mär 2012 (20 resultados)

Buch. Condición: Neu. Neuware -This book is a collection of essays on the reception of Leibniz¿s thinking in the sciences and in the philosophy of science in the 19th and 20th centuries. Authors studied include C.F. Gauss, Georg Cantor, Kurd Lasswitz, Bertrand Russell, Ernst Cassirer, Louis Couturat, Hans Reichenbach, Hermann Weyl, Kurt Gödel and Gregory Chaitin. In addition, we consider concepts and problems central to Leibniz¿s thought and that of the later authors: the continuum, space, identity, number, the infinite and the infinitely small, the projects of a universal language, a calculus of logic, a mathesis universalis etc. The book brings together two fields of research in the history of philosophy and of science (research on Leibniz, and the research concerned with some major developments in the 19th and 20th centuries); it describes how Leibniz¿s thought appears in the works of these authors, in order to better understand Leibniz¿s influence on contemporary science and philosophy; but it also assesses that reception critically, confronting it in particular with the current state of Leibniz research and with the various editions of his work.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 292 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -The Autumn 2011 (vol. 13 no. 3) issue of the Nexus Network Journal features nine papers guest edited by José Calvo-Lopez dedicated to the theme ¿From Mediaeval Stonecutting to Projective Geometry ¿. This is an outgrowth of the session by the same name which took place during the eighth international, interdisciplinary conference ¿Nexus 2010: Relationships between Architecture and Mathematics, held in Porto, Portugal, in June 2010. The topics discussed range from the theoretical mathematics to built examples both historical and contemporary. The issue is completed with other research papers, conference reports and book reviews.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 296 pp. Englisch.

Buch. Condición: Neu. Neuware -In the 1970s Hirzebruch and Zagier produced elliptic modular forms with coefficients in the homology of a Hilbert modular surface. They then computed the Fourier coefficients of these forms in terms of period integrals and L-functions. In this book the authors take an alternate approach to these theorems and generalize them to the setting of Hilbert modular varieties of arbitrary dimension. The approach is conceptual and uses tools that were not available to Hirzebruch and Zagier, including intersection homology theory, properties of modular cycles, and base change. Automorphic vector bundles, Hecke operators and Fourier coefficients of modular forms are presented both in the classical and adèlic settings. The book should provide a foundation for approaching similar questions for other locally symmetric spaces.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 272 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were overshadowed some time later by the occurrence of vector-related leukaemia in a number of treated children. It is in this context that lentiviral vectors have appeared, with improved efficiency and, possibly, increased biosafety. Very recently, the first clinical trials with lentivectors have been carried out with some success.This Brief firstly defines gene therapy, and places lentivectors within this fascinating therapeutic strategy. Then follows a comprehensive description of the development of retroviral and lentiviral vectors and how to specifically target distinct cell types and tissues. The authors also discuss the application of lentivector gene therapy for the treatment of cancer and autoimmune diseases, ending with the application of lentivectors in human gene therapy clinical trials.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 116 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -This book presents recent results on nonlinear parabolic-hyperbolic coupled systems such as the compressible Navier-Stokes equations, and liquid crystal system. It summarizes recently published research by the authors and their collaborators, but also includes new and unpublished material. All models under consideration are built on compressible equations and liquid crystal systems. This type of partial differential equations arises not only in many fields of mathematics, but also in other branches of science such as physics, fluid dynamics and material science.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 184 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -Oxidative stress and aging Over the past several years there has been an extraordinarily rapid growth in our knowledge of free radical chemistry and its possible involvement in both normal essential biology and age related disease and dysfunction. Much of this growth in the traditionally separate sciences of chemistry and molecular gerontology occurred independently, with little interaction or communi cation between the scientists working in these two fields. In view of the growing maturity of the two fields and the potential importance of advancing our knowledge in the area of oxidative stress and aging, we perceived a critical need to organize an international conference the 'First Inter national Conference on Oxidative Stress and Aging' in Hawaii in 1994 to bring together the world's leading scientists in the fields of reactive oxygen species and molecular gerontology. The objective of this conference was to provide a unique opportunity for scholars working in these two related and rapidly growing fields to participate in the exchange, integration, and synthesis of new concepts and ideas, to engage in constructive criticism and to initiate new collaborative research projects. The conference focused on the molecular and cellular aspects of aging as related to oxidative stress. It was one of the largest and most comprehensive international conferences held in molecular gerontology. At this conference a call was made for submission of papers to be used in the publication of a book covering the major contributions of the meeting.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 416 pp. Englisch.

Buch. Condición: Neu. Neuware -Medical research involving human subjects has contributed to considerable advancements in our knowledge, and to medical benefits. At the same time the development of new technologies as well as further globalisation of medical research raises questions that require the attention of researchers from a range of disciplines. This book gathers the contributions of researchers from nine different countries, who analyse recent developments in medical research from ethical, historical, legal and socio-cultural perspectives. In addition to reflections on innovations in science such as genetic databases and the concept of ¿targeted therapy¿ the book also includes analyses regarding the ethico-legal regulation of new technologies such as human tissue banking or the handling of genetic information potentially relevant for participants in medical research. Country and culture-specific aspects that are relevant to human medical research from a global perspective also play a part. The value of multi- and interdisciplinary analysis that includes the perspectives of scholars from normative and empirical disciplines is a shared premise of each contribution.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 204 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Multivariate Approximation Theory forms a rapidly evolving field in Applied Mathematics. The reason for its particular current interest lies in its impact on Computer Aided Geometric Design (CAGD), Image Processing, Pattern Recogni tion, and Mult idimensional Signal Processing. Mul ti var iate Bernstein polynomials and box splines, for example, play an important role in CAGD. Conversely, the highly important filter bank design problem of signal processing, for instance, gives rise to a new family of multivariate approximating functions, the Gabor wavelets, with interesting technological and biological applications. The conferences on Multivariate Approximation Theory held at the Mathematical Research Institute at Oberwolfach, Black Forest, in 1976, 1979, 1982, 1985 and 1989 ref lect the progress made in this area and related fie Ids. The present volume which is a continuation of the preceding volumes Constructive Theory of Functions of Several Variables, Lecture Notes in Mathematics 571 (1977) Multivariate Approximation Theory, ISNM 51 (1979) Multivariate Approximation Theory II, ISNM 61 (1982) Multivariate Approximation Theory III, ISNM 75 (1985) is based on the conference held on February 12-18, 1989. It includes most of the lectures presented at the Oberwolfach meeting and reveals the wide spectrum of activities in the field of multivariate approximation. The organizers are grateful to the Director of the Oberwolfach Mathematical Research Institute, Professor Dr. M. Barner, and his staff for providing the facili ties, and to Dr. G. Baszenski, Professor Dr. F. J. Delvos, Dr. H. 356 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The present Volume contains the contributions to the fourth meeting on Unilateral Problems in Structural Analysis, held at Capri on June 14 to 16,1989. The preceding meetings took place at Villa Emma, near Udine, on May 1982, at Ravello on September 1983 and again at Villa Emma on June 1985. Publication of the proceedings started with the second meeting; the two resulting volumes were published by Springer Verlag, Vienna, under the series Cism Courses and Lectures. Unilateral Problems appear as a singular example of confluence of interests: they are the object of the attention of pure and applied mathematicians, of specialists in Continuum Mechanics and engineers. The idea which gave origin to this series of meetings was that of putting together people coming from such different fields. The result was an extremely fruitful exchange of experiences; it contributed, we believe, to the improvement of the knowledge in the area. The contents of the present Volume reflects the composite character of the meeting. There are contributions in the mathematical theory (Has linger, Panagiotopoulos, Romano), and studies in classical problems of Mechanics such as unilateral contact with friction (Kalker, Klarbring, Licht, Telega), Plasticity (Corradi, Del Piero, Owen) and composite materials and structures (Bruno, Leonardi). Some contributions deal with not yet completely explored questions of unilateral dynamics (Guo, Jean); finally, a contribution (Bennati) concerns the comparatively new subject of masonry structures, in which the unilateral constraint enters at the constitutive level. 240 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 396 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -1. Quaternionic Analysis.- 1.1. Algebra of Real Quaternions.- 1.2. H-regular Functions.- 1.3. A Generalized LEIBNIZ Rule.- 1.4. BOREL-POMPEIU¿s Formula.- 1.5. Basic Statements of H-regular Functions.- 2. Operators.- 2.3. Properties of the T-Operator.- 2.4. VEKUA¿s Theorems.- 2.5. Some Integral Operators on the Manifold.- 3. Orthogonal Decomposition of the Space L2,H(G).- 4. Some Boundary Value Problems of DIRICHLET¿s Type.- 4.1. LAPLACE Equation.- 4.2. HELMHOLTZ Equation.- 4.3. Equations of Linear Elasticity.- 4.4. Time-independent MAXWELL Equations.- 4.5. STOKES Equations.- 4.6. NAVIER-STOKES Equations.- 4.7. Stream Problems with Free Convection.- 4.8. Approximation of STOKES Equations by Boundary Value Problems of Linear Elasticity.- 5. H-regular Boundary Collocation Methods.- 5.1. Complete Systems of H-regular Functions.- 5.2. Numerical Properties of H-complete Systems of H-regular Functions.- 5.3. Foundation of a Collocation Method with H-regular Functions for Several Elliptic Boundary Value Problems.- 5.4. Numerical Examples.- 6. Discrete Quaternionic Function Theory.- 6.1. Fundamental Solutions of the Discrete Laplacian.- 6.2. Fundamental Solutions of a Discrete Generalized CAUCHY-RIEMANN Operator.- 6.3. Elements of a Discrete Quaternionic Function Theory.- 6.4. Main Properties of Discrete Operators.- 6.5. Numerical Solution of Boundary Value Problems of NAVIER-STOKES Equations.- 6.6. Concluding Remarks.- References.- Notations. 256 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Seventh International Conference of the Inflammation Research Association, entitled 'Inflammation, Mechanisms and Therapeutics' was held on September 25-29,1994 in White Haven, Pennsylvania. The major focus of this series of conferences is the multidisciplinary investigation of inflammation and the discovery of novel therapeutic approaches to inflammatory diseases. It was therefore particularly gratifying that the list of attendees included scientists of diverse backgrounds - preclinical biology, synthetic and theoretical chemistry, biotechnology and clinical research. The Conference was characterized by a very high degree of participation in the scientific debate by attendees, a large proportion of whom presented at poster sessions, poster discussions and workshops, and by the many opportunities for informal discussion provided by the organizers. This volume captures much of the excitement and enthusiasm of the Conference and should be a valuable resource for scientists in the field. Niall S. Doherty Barry M. Weichman Douglas W. Morgan Lisa A. Marshall IX Acknowledgments The manuscripts contained in this volume are based on material presented at the Seventh International Conference of the Inflammation Research Association held in White Haven, Pennsylvania, on September 25-29,1994. We would like to thank the speakers and session chairpersons for their contributions to the Conference and these Proceedings. The following individuals played indispensable roles in the organization and running of the Conference and are responsible for making it such a success: PLANNING SCHOLARSHIP Niall S. Doherty Janet Kerr, Chairperson Barry M. Weichman Richard Carlson Douglas Morgan Richard Harris Loran Killar D. 228 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Histamine is an intriguing compound; the same is true for the several classes of anti-histaminergic compounds. The classical anti-histamines, now known as H -antagonists have 1 been the result of intensive research in the 1950s and 1960s. The new, so-called non-sedating H1-antagonists, which became available in the 1980s, could be d'eveloped mainly due to insights into structural features causing the sedating effects of the older compounds. In the 1970s the H2-receptors became important targets for developing new anti-ulcer agents. The H2-antagonist story is a stimulating example of modern research on pharmacology and medicinal chemistry. Unknown and new properties of histamine and histaminergic systems came to the attention of the pharmacologists and medicinal chemists in the 1980s. The role of histamine as a neurotransmitter, the existence of a presynaptic receptor (H ) controlling the release of histamine 3 and other neurotransmitters, and the particular character of this receptor became important as the possibilities to design new therapeutic agents were realized. Recently, other roles of the histaminergic systems have been suggested. Is there a distinct histamine receptor involved in immunological features of histamine Is histamine involved in the prolactin axis Are histamine receptors intracellularly present in certain cells and what is their possible role For these reasons it was the right time to discuss 'New Perspectives in Histamine Research' during a scientific meeting. Therefore a symposium was organized as a satellite of the XIth International Congress of Pharmacology of IUPHAR in Amsterdam in 1990. 444 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book contains the proceedings of the 2nd Cologne Ath~roscle rosis Conference (CAC) which was devoted to lipids, in particular lipoproteins. The object of the conference series, organised by A. Nattermann & Cie. GmbH, Cologne, is to provide an overview of various fields either directly related to or associated with the process of atherosclerosis. Having considered the associated field of inflammation in the first conference, the 2nd CAC dealt with a subject intimately related to the atherosclerotic process per see The recent demonstration in an extensive clinical study of a close link between high plasma cholesterol and coronary mortality has awakened both the medical and the lay communities to the importance of research into lipoprotein biochemistry and physiology. This can only be good news since more intensive research into lipoprotein functions is vital for future therapy of atherosclerosis and other lipid disorders. The status of research on lipoproteins is reflected in the contributions to this book, which are of an interdisciplinary nature, including both reviews and shorter research reports by acknowledged experts in the field. Special thanks are due to Margret Leffin for her organisational and secretarial assistance at all stages and to Dr. D. Bowyer and Prof. W. Stoffel for their advice and assist ance with the programme. Cologne, July 1984 Michael J . Parnham Lipoprotein Synthesis and Receptor Interactions 17 AAS 16: 2nd Cologne Atherosclerosis Conference 1984 1984 Birkhiiuser Verlag Basel APOLIPOPROTEIN GENES, DNA POLYMORPHISMS AND HYPERLIPIDEMIA c. c. Shoulders and F. E. 248 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The benzodiazepines are among the most widely-used of drugs. However, in many countries their popularity is waning as prescribers become more aware of problems with unwanted effects and with rebound and withdrawal syndromes. The earlier benzodiazepines were long-acting, and it was thought that their shorter-acting successors would have important advantages. Other developments include partial agonists and partial inverse agonists, compounds acting on the benzodiazepine-GABA macro molecular site although not as a typical benzodiazepine, and anxiolytic agents acting on 5-HT pathways directly. I shall review the problems of unwanted effects and dependence, mainly from an epidemiological view point, and then relate the pharmacological properties of the newer com pounds to possible differences in their clinical profile of adverse effects. Adverse behavioural effects Benzodiazepines are used, inter alia, as anxiolytics and hyp notics. The latter use exploits the sedative actions which occur at higher than anxiolytic doses. The sedation should disappear by the time the patient wakes up. Hypnotics are thus unique in that their wanted effect and unwanted effect are identical - sedation - but separated in time by about 8 hours. 156 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The finite difference and finite element methods are powerful tools for the approximate solution of differential equations governing diverse physical phenomena, and there is extensive literature on these discre tization methods. In the last two decades, some extensions of the finite difference method to irregular networks have been described and applied to solving boundary value problems in science and engineering. For instance, 'box integration methods' have been widely used in electro nics. There are several papers on this topic, but a comprehensive study of these methods does not seem to have been attempted. The purpose of this book is to provide a systematic treatment of a generalized finite difference method on irregular networks for solving numerically elliptic boundary value problems. Thus, several disadvan tages of the classical finite difference method can be removed, irregular networks of triangles known from the finite element method can be applied, and advantageous properties of the finite difference approxima tions will be obtained. The book is written for advanced undergraduates and graduates in the area of numerical analysis as well as for mathematically inclined workers in engineering and science. In preparing the material for this book, the author has greatly benefited from discussions and collaboration with many colleagues who are concerned with finite difference or (and) finite element methods. 212 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -One of the currently most expanding and exciting areas in cardiovascular research is the study of receipt and dispatch of chemical signals by different cell types. Major progress has been made during the last years and a number of intercellular mediators have been structurally identified and their regulation studied. The impressive developments in molecular biology have provided most effective tools, enabling us to understand message generation in much more detail than anyone would have appreciated a couple of years ago. These developments also have a major impact on cardiovascular pharmacology. This involves both the molecular design of new drugs as well as an improved understanding of how established drugs act. Clearly, changes in one mediator system will also affect others and it might be difficult to take out just one factor and to ignore others. This is definitely true for myocardial ischemia where many different mediators are synthesized and released at about the same time, resulting in a complex picture of events and an even more difficult selection of the most appropriate drug therapy.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 348 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Volume 45 of 'Progress in Drug Research' contains eight reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with neuro peptides as native immune modulators, with Calmodulin and with effects of cell stimuli and drugs on cellular activation, with recent advances in benzodiazepine receptor binding studies, with the medicinal chemistry and therapeutic potentials of ligands of the histamine H3 receptor, with Serotonin uptake inhibitors, with computer-aided drug design, with natri uretic hormones and with the recent developments in the chemotherapy of osteoporosis. In the 36 years that PDR has existed, the Editor has enjoyed the valu able help and advice of many colleagues. Readers, the authors of the reviews and, last but not least, the reviewers have all contributed greatly to the success of this series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a series of monographs. So far, it has been the Editor's intention to help disseminate information on the vast domain of drug research, and to provide the reader with a tool with which to keep abreast of the latest developments and trends. The reviews in PDR are useful to the nonspecialist, who can obtain an overview of a particular field of drug research in a relatively short time.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 392 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 460 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders.Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 280 pp. Englisch.