springer basel birkhäuser basel birkhäuser apr 2012 (21 resultados)

Taschenbuch. Condición: Neu. Neuware -Zoonosen sind Krankheiten bzw. Infektionen, die auf natürlichem Weg direkt oder indirekt zwischen Menschen und Tieren übertragen werden können. Mit Zoonoseerregern kontaminierte Lebensmittel stellen eine wichtige Infektionsquelle für den Menschen dar. Beim Zoonosen-Monitoring werden repräsentative Daten über das Auftreten von Zoonoseerregern in Lebensmitteln, Futtermitteln und lebenden Tieren erfasst, ausgewertet und veröffentlicht. Weiterhin dient das Zoonosen-Monitoring der Überwachung von Antibiotikaresistenzen bei Zoonoseerregern und anderen Mikroorganismen.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 60 pp. Deutsch.

Taschenbuch. Condición: Neu. Neuware -Geometrie der Tone ist die aktualisierte und ausgearbeitete Fassung einer interdisziplinaren Vorlesung iiber Mathematische Musiktheorie an der Universitat Ziirich im akademischen Jahr 1986/87. Das Buch richtet sich an einen breiten, interessierten Leserkreis, der sich iiber den Status quo dieser Theorie ein Bild mach en mochte. Es wird da her grosste Sorgfalt und Zuriickhaltung geiibt in der Entwicklung des mathematischen Formalismus. Das zentrale Anliegen der Theorie ~ die Vermittlung zwischen musikalischer Form und ihrer Bedeutung ~ bleibt stets im Mittelpunkt der Darstellung. Der Status quo der Mathematischen Musiktheorie (MaMuTh) ist das Resultat einer zehnjahrigen Forschungsperiode, in welcher die Durchdringung und Verwebung systematischer Musikwissenschaft mit der Sprache, den Methoden und den Erkenntnissen der modernen Ma thematik angestrebt wurde. Besonderes Gewicht erhalt die Geome trisierung abstrakter Sachverhalte. ~ Musik erweist sich in diesem U nternehmen als das im Vieldeutigen Bestimmte und darin als Ge genstand, welcher den Paradigmen heutiger Mathematik in natiirli cher Weise entspricht. Die MaMuTh macht der Musikwissenschaft eine prazise, anschauliche und undogmatische Sprache verfiigbar, welche in ihrer Universalitat keine Einschrankung des kulturellen oder histori schen Blickwinkels impliziert, sondern vielmehr durch Spezialisierung der allgemeinen Techniken eine Varietat adaquater Perspektiven an bietet. XIV Vorwort Uber eine im Zeitalter der Computertechnologie iiberfaJlige sprachlich-formale Fundierung hinaus kann von der MaMuTh als ei ner Theorie gesprochen werden, die - wie die Physik zur materiellen Natur - Modelle zum Phiinomen Musik der menschlichen Natur be reitstellt.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 384 pp. Deutsch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Twenty-First International Congress of Mathematicians (ICM) was held in Kyoto, Japan, from August 21 through 29, 1990, the first congress that has taken place in the Eastern hemisphere. On this occasion, Japanese historians of mathe matics organized the History of Mathematics Symposium which was held at the Sanjo Conference Hall of the University of Tokyo on August 31 and September 1, as one of the related conferences of the Congress. The symposium was officially sponsored by the Executive Committee of the ICM 90, the History of Science So ciety of Japan, and the International Commission on the History of Mathematics. The Executive Committee consisted of Murata Tamotsu (Chairperson, Momoyama Gakuin University), Sugiura Mitsuo (Vice-Chairperson, Tsuda College), Sasaki Chikara (Secretary, The University of Tokyo), Adachi Norio (Waseda University), Nagaoka Ryosuke (Tsuda College until 1990, now Daito Bunka University), and Hirano Yoichi (Treasurer, Tokai University). The symposium emphasized the following three fields of study: (1) mathe matical traditions in the East, (2) the history of modern European mathematics, and (3) interaction between mathematical research and the history of mathemat ics. These fields were chosen mainly because, first, the symposium was related to the ICM, the most important congress of working mathematicians, and, second, the Kyoto ICM was held in a non-Western country for the first time. The sym posium consisted of the two Sessions: Session A for invited speakers and Session B for short communications. 262 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Als P. R. Fuss, ein Urenkel Leonhard Eulers und seinerzeit standi ger Sekretar der Petersburger Akademie der Wissenschaften, das zweibandige Werk Mathematischer und physikalischer Briefwech sel einiger bedeutender Geometer des 18. Jahrhunderts heraus gab, reservierte er den erst en Band fiir den Briefwechsel seines 1 beriihmten UrgroBvaters mit dessen Freund Christian Goldbach. 1m zweiten Band nimmt die Korrespondenz Goldbachs mit zwei 2 Vert ret ern der Familie Bernoulli, mit Nikolaus II und Daniel , einen beachtlichen Platz - mehr als 300 Seiten - ein. AIle diese Gelehrten des 18. Jahrhunderts waren Mitglieder der Pe tersburger Akademie der Wissenschaften. Euler und Daniel Ber noulli genieBen Weltruhm, Nikolaus II Bernoulli starb ganz jung, ohne geniigend Zeit gehabt zu haben, sein offensichtlich vorhan denes Talent zu entfalten. Goldbachs wissenschaftliche Verdienste sind weitaus weniger bekannt, obwohl jeder Mathematiker schon etwas von der Goldbachschen Vermutung in der Zahlentheorie gehort hat. Fuss auBerte sich tiber Goldbach folgendermaBen: 'Sein Briefwechsel zeigt, daB es der graBen Breite seiner Kennt nisse geschuldet ist, wenn er auf keinem Spezialgebiet beriihmt wurde. Bald sehen wir ihn mit Bayer knifRige Fragen der klassi schen und orientalischen Philologie behandeln; bald laBt er sich auf endlose Streitereien liber Archaologie mit dem berlihmten Stosch ein; hier zieht ihn Biilfinger zu den damals in Mode kom menden metaphysischen Spekulationen heran, die indessen zu rein gar nichts fiihrten; dort regen Euler und die Bernoulli ihn an, sich mit Mathematik zu beschaftigen und weihen ihn in die Geheimnisse der hoheren Analysis und der Zahlentheorie ein. 252 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The Indian National. Science Academy has planned to bring out monographs on special topics with the aim of providing acce~sible surveys/reviews of topics of current research in various fields. Prof. S. K. Malik, FNA, Editor of Publications INSA asked me in October 1997 to edit a volume on algebra in this series. I invited a number of algebraists, several of them working in group rings, and it is with great satisfaction and sincere thanks to the authors that I present here in Algebra: Some Recent Advances the sixteen contributions received in response to my invitations. I. B. S. Passi On Abelian Difference Sets K. r Arasu\* and Surinder K. Sehgal 1. Introduction We review some existence and nonexistence results - new and old - on abelian difference sets. Recent surveys on difference sets can be found in Arasu (1990), Jungnickel (1992a, b), Pott (1995), Jungnickel and Schmidt (1997), and Davis and Jedwab (1996). Standard references for difference sets are Baumert (1971), Beth et al. (1998), and Lander (1983). This article presents a flavour of the subject, by discussing some selected topics. Difference sets are very important in combinatorial design theory and in commu nication engineering while designing sequences with good correlation properties. Our extended bibliography covers a wide variety of papers written in the area of difference sets and related topics.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 260 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book is devoted to one of the central problems of contemporary thinking, for which c.P. Snow in 1959 coined the phrase of the «Two Cultures». In this concept, human endeavour is directed on one side to the (forward-looking) sci ences (mathematics, physics, chemistry, biology, etc.) and on the other side to the (backward-looking) humanities (including psychology, linguistics, sociology, etc.). In this dichotomy Snow saw no possibility of unification. On the other hand the urge towards self-consistency and harmony in the mental and spiritual lives of both man and society as a whole is clearly one of the major forces of creativity, both scientific and artistic. This force aims at the unification of the «Two Cultures» in order to build an integrated self-consistent system for our intellectual life. Some attempts in this direction have been made before, and will be described in this book. It is our aim to contribute to the achievement of an integrated mental life on the basis of information theory. In order to construct our model, we examine the laws of information theory, leading us to the deduction of the main laws inherent in both «cultures». Thus, we consider the evolution of both non-living and living matter, human behaviour, the phenomenon of language, the sphere of aesthetics, etc. We hope that our work will be useful both for researchers (who are trying to derive different integral theories) and for various other «consumers» of scientific knowledge (meaning broad circles of intellectuals).Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 200 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -1. Endothelins.- 2. Bradykinin.- 3. Tachykinins and Calcitonin Gene-Related Peptide.- 4. Vasoactive Intestinal Peptide.- 5. Atrial Natriuretic Peptides.- 6. Platelet-Derived Growth Factor, Transforming Growth Factor- and Connective Tissue Growth Factor.- 7. Voltage-Dependent and Receptor-Operated Calcium Channels.- 8. High Conductance Calcium-Activated Potassium Channels.- 9. Adenosine Triphosphate-Activated Potassium Channels.- 10. Sodium/Potassium/Chloride Co-Transport.- 11. Sodium/Hydrogen Exchange.- 12. Sodium/Potassium-Dependent Adenosine Triphosphatase. 278 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Among the various theories proposed to account for the process of aging, the free radical theory is of practical interest since it includes the possibility of retarding this process by administrating natural or synthetic antioxidants and free radical scavengers. The book 'Free Radicals and Aging' summarizes knowledge accumulated during recent years in 42 reviews written by experts in the field. Aspects of free radical involvement in the intrinsic aging process and in age-related diseases, as well as the importance of the pro-antioxidant balance throughout life are discussed. Epidemiological studies from several European countries are reported showing correlations between low plasma levels of essential antioxidants and the occurence of coronary heart disease, cancer and cataract formation. Appropriate nutrition as well as prophylactic and therapeutic use of antioxidants are considered. This book represents a milestone in the field of age-related free radical biology and medicine. With contributions by: A. Azzi, B. Chance, R.G. Cutler, H. Esterbauer, P.H. Evans, F. Gey, C. Guarneri, D. Harman, N.I. Krinsky, M. Meydani, J. Miquel, A. Mori, L. Packer, C. Rice-Evans, M. Simic, A. Taylor, T. Yoshikawa. 444 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The main part of this paper concerns Toeplitz operators of which the symbol W is an m x m matrix function defined on a disconnected curve r. The curve r is assumed to be the union of s + 1 nonintersecting simple smooth closed contours rOo r -. . . - rs which form the positively l oriented boundary of a finitely connected bounded domain in t. Our main requirement on the symbol W is that on each contour rj the function W is the restriction of a rational matrix function Wj which does not have poles and zeros on rj and at infinity. Using the realization theorem from system theory (see. e. g . - [1]. Chapter 2) the rational matrix function Wj (which differs from contour to contour) may be written in the form 1 (0. 1) W . (A) = I + C. (A - A. f B. A E r J J J J J where Aj is a square matrix of size nj x n- say. B and C are j j j matrices of sizes n. x m and m x n . - respectively. and the matrices A. J x J J and Aj = Aj - BjC have no eigenvalues on r . (In (0. 1) the functions j j Wj are normalized to I at infinity. 410 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 634 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Der Band enthalt Manuskripte zu Vortragen, die auf einer von den Herausgebern geleiteten Tagung tiber 'Numerische Methoden der Approximationstheorie' am Mathematischen Forschungsinstitut Ober wolfach in der Zeit vom 18. -24. Januar 1981 gehalten wurden. Das Spektrum der Vortrage reichte von der klassischen Approximations theorie tiber mehrdimensionale Approximationsverfahren bis hin zu praxisbezogenen Fragestellungen. Zu den zuerst genannten Gebieten gehorten z. B. die Verfeinerung von Fehlerabschatzungen bei der Polynominterpolation, Fragen zur Eindeutigkeit, Charakterisierung optimaler Interpolationsprozesse und Algorithmen zur rationalen Interpolation. Bei den weiteren genannten Gebieten spiegel ten zahlreiche Vortrage das steigende Interesse an der mehrdimensio nalen Interpolation, insbesondere mit verschiedenen Arten von Splines wider. Hier standen u. a. Probleme der Parameterschatzung in der Medizin und Flugtechnik, Fragen der Approximationstheorie bei der Konstruktion von Plottern und stabile Algorithmen beim Arbeiten mit mehrdimensionalen B-Splines im Mittelpunkt des Interesses. Die Tagung lieferte einen reprasentativen Ueberblick tiber die aktuellen Trends in der Approximationstheorie. Zum guten Erfolg der Tagung trug wie immer die hervorragende Be treuung durch die Mitarbeiter und Angestellten des Instituts so-' wie das verstandnisvolle Entgegenkommen des Institutsdirektors, Herrn Professor Dr. Barner, bei. Un serer besonderer Dank gilt dem Birkhauser Verlag ftir die wie stets sehr gute Ausstattung. Helmut Werner Lothar Collatz Gtinther Meinardus Hamburg Mannheim Bonn 7 INDEX Blatt, H. -P. Strenge Eindeutigkeitskonstanten und Fehlerabschatzungen bei linearer Tschebyscheff-Approximation 9 Bohmer, K. Polynom- und Spline-Interpolation (Ein Farbfilm) 26 Brannigan, M. A Multivariate Adaptive Data Fitting Algorithm 30 Brass, H. Zur numerischen Berechnung konjugierter Funktionen 43 Bultheel, A. 268 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since the appearance of photosynthesis on our planet, all living organisms have been facing a new abundant, extremely reactive element, oxygen. This element is used for the synthesis of highly energetic compounds, but can also generate molecules capable of damaging constituents of living structures, including proteins, nucleic acids and lipids. It is therefore no surprise that all biological organisms have evolved multiple and sophisticated ways to reduce the detrimental effects of oxygen. For cells and tissues of highly organized animals, particularly cells of the immune system, superoxidation products play an important role, via oxidative stress, in activation, inflammation and viral and bacterial infections. We must be grateful to Drs. C. Pasquier, C. Auclair, L. Packer and R. Olivier for having brought together many specialists in an international meeting held in Paris in March 1993, at the Ministry of Research. This book comprises an impressive amount of recent knowledge, a real mine for the reader in this fast developing field of research. Furthermore, we should not forget that this basic research may lead in the future to new therapeutic approaches to the most important pathologies of the latter part of this century, including AIDS. 362 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Airway Hyperreactivity.- Airway hyperreactivity, an introduction.- An alternative point of view on experimental lung hyperreactivity.- Isolated and dual type of late asthmatic response (LAR) ¿ The clinical characteristics and pharmacologic control.- Delayed asthmatic response (DAR) and its pharmacologic modulation.- Cytologic changes in the nasal secretions (NS) during the immediate (INR) and late nasal response (LNR) to allergen challenge (NPT).- Airway diameter determines flow-resistance and sensitivity to contractile mediators in perfused bronchial segments.- Modulating effects of antiasthmatic and antitussive drugs on autonomic neurotransmission in guinea-pig bronchial muscle in vitro.- Effect of subacute exposure to nitrogen dioxide on the airway responsiveness of guinea pig.- Tocoxara canis-induced airway hyporeactivity in mice.- Plasticisers, another burden for asthmatics .- Inflammatory Cells and Mediators.- Eicosanoids and inflammatory cells in asthma.- The effect of prostanoids on the function of human eosinophils.- Modulation of guinea pig airway reactivity by the linoleic acid metabolite, 13-hydroxy-octadecadienoic acid (13-HODE).- The effects of drugs on lung hyperreactivity in sephadex treated rats.- Adenyl cyclase activity in human alveolar macrophages.- Activated human granulocytes contract isolated human airways.- Pulmonary surfactant secretion in type II pneumocytes in inflamed condition.- Superoxide production by broncho-alveolar cells is diminished in parainfluenza-3 virus treated guinea pigs.- Oxidative stress and receptor responses in guinea-pig tracheal tissue.- Cytokines.- Cytokines and bronchial hyperreactivity.- Effect of lymphokines on -adrenoceptor stimulation of human PBMC.- A role for T cells in the induction of airway hyperreactivity.- Peptides.- Neuropeptides as modulators of airway function.- Modulation of cholinergic neurotransmission by VIP, VIP-antiserum and VIP-antagonists in dog and cat trachea: VIP plays a role of ¿double braking¿ in broncho-constriction.- Characterisation of the neurokinin receptors mediating contraction of isolated tracheal preparations from a variety of species.- Inhibition by calcitonin gene-related peptide of agonist-induced bronchoconstriction in various mammals including man.- Sensory neuropeptides are involved in cigarette smoke-induced airway hyperreactivity in guinea-pig.- Amino acids as modulators of cholinergic nerves in airways.- Contractile effects and receptor distributions for endothelin-1 (ET-1) in human and animal airways.- Binding characteristics of [125I] endothelin-1 in guineapig trachea and its displacement by endothelin-1, endothelin-3 and endothelin (16-21).- Endothelin-1 increases airway mucosa blood flow in the pig.- Platelet-Activating Factor.- PAF receptors in guinea-pig and human lung.- Selective implication of thromboxane A2 and PAF-acether in two guinea pig anaphylactic models.- Effects of a novel PAF antagonist, E6123, on PAF-induced biological responses.- Effects of a novel PAF antagonist, E6123, on passive anaphylaxis.- Epithelium-Derived Factors.- Putative role of epithelial derived factors in airway smooth muscle reactivity.- The role of epithelium in the responsiveness of the bronchi to stimuli.- Additive effect of epithelial denudation and low levels of inflammatory mediators on the sensitivity of isolated human airways to methacholine.- Epithelium-derived linoleic acid metabolites modulate airway smooth muscle function.- Author index. 296 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Proteases, Protease-Derived Peptides and Protease Inhibitors Many physiological as weil as pathophysiological processes are mediated by proteases and the products of their actions, protease-derived peptides. However, the uncontrolled activity of proteases can be extraordinarily destructive and dangerous to normal biologie systems. As a result, biology has gone to great lengths to control the activities of the proteases involved in these systems by developing aseries of both highly specific (regulatory) and non-specific (protective) anti-proteases. The protease/anti-protease balancing activities include the normal homeostatic processes of clotting and clot lysis, hormonal regulation of blood pressure and the control of the inflammatory response represented by both the humoral (the kallikrein-kinin and complement systems) and cellular (neutrophil and macrophage derived proteases) components of the inflammation. Examples of successful therapies directed at these protease dependent systems include the use of warfarin and heparin to control thrombosis and streptokinase or tissue plasminogen activator (tPA) for the acceleration of clot dissolution. Similarly, the use of angiotensin converting enzyme (ACE, a type of limited activity protease or peptidase) inhibitors has made a significant impact on the treatment of hypertension. Lastly, the restitution of normal antiprotease levels by the infusion of the purified protein in patients with genetic alpha-1-antiprotease deficiency is regularly being used to reduce the rate of lung function 1055 caused by the unopposed activity of human neutrophil elastase in these individuals. 248 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -It is well known that basic science can trigger an invention of considerable technological and commercial importance. Indeed basic science and invention are often inextricably linked, each being able to catalyse the other. To engender such developments it is important that there should be good communication between the scientist and the technologist. The field of membrane biotechnology is a growing field where such communication is increasingly taking place and where new inventions are occurring. This book provides an overview of this developing field. It contains chapters by scientist and technologists working in the field of Membrane Biotechnology. The chapters cover the latest advances in basic science as well as some recent technological applications. The basic topics include the application of dynamic X-ray diffraction to lipid water systems, FTIR spectroscopy applied to membrane proteins, fluorescent analogues of phosphoinositides, studies of platelet activating factor, antibody binding to model membranes and phospholipase C induced fusion. The technological topics described include the development of new haemocompatible materials based upon biomembrane mimicry, new lung surfactant materials, drug delivery systems including liposomes and the development of new biosensors including Langmuir Blodgett films. The meeting showed that there are many other useful applications in the pipeline. The potential for new polymeric drug delivery systems, of ion selective systems based on the knowledge of ion-channel protein structures, of new plastics for cell growth and cellular engineering for artificial organs. These are among the interesting developments that are emerging in this field. 342 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -About 80 scientists from allover the world have gathered at the Parc Valrose Scientific Campus of Nice -Sophia Antipolis University, for the 5th UNESCO International Conference on 'Water and Ions in Biornolecular Systems', to present and discuss current problems in the field. The Conference proceedings comprise selected and reviewed contributions of invited plenary lectures, lectures and posters presentations which cover all the Biophysical sectors of research on the following three major topics : Water, Ions and Nucleic Acids Water, Ions and Membranes Water, Ions and Proteins The organizers of the 5th UNESCO International Conference on 'Water and Ions in Biomolecular Systems' have obtained financial support from various sponsors. They would like to express their appreciation and gratitude to these organizations for the valuable moral and financial support which has made the arrangement of these Conference in Nice possible. The Meeting has been sponsored by : United Nations Educational Scientific and Cultural Organization The University of Nice -Sophia Antipolis D. R. E. T. (Defence Ministery) Conseil General des Alpes Maritimes Ville de Nice The International Union of BiochernistIy The International Union of Pure and Applied Biophysics Banque Nationale de Paris Air Liquide Nice Congres The Executive Committee, Professors J. JAZ, B. PULLMAN and D. 297 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Bronchial asthma is a disease with many unsolved problems and despite an increased availabili ty of anti-asthma drugs, morbidi ty and mortality from this disease are not improving. It is now recognized that asthma should be considered as a chronic inflammatory disease of the lung resulting in bronchial hyperreactivity and subsequent symptoms. The mechanisms underlying airways inflammation and bronchial hyperreactivity have now become a focal point of research in the quest for knowledge about how the management of this disease can be improved. Platelet activating factor (PAF-acether AGEPC) is a naturally occurring ether-linked phospholipid discovered in 1972 associated with IgE mediated allergic responses which has potent effects on platelet activation. PAF is now recognized as a molecule having a diverse range of biological effects relevant to allergic inflammation and asthma including the abili ty to induce long lasting airway inflammation and associated increases in bronchial reactivity. Certain activities of PAF are known to be secondary to platelets activation raising the possibility that this blood element plays a role in the pathogenesis of asthma. 260 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The present volume contains manuscripts of lectures or topics related to the lectures which were given at the conference on 'Inverse Problems' at the mathematical Research Institute at Oberwolfach. The conference took place during the week of May 18-24, 1986, and was managed by the editors. Recalling Professor Joseph Keller's paper entitled Inverse Problems, American Mathematical Monthly, 83 (1976), we give two direct quotes. 'We call two problems inverses of one another if the formulation of each involves all or part of the solution of the other. Often, for historical reasons, one of the two problems has been studied extensively for some time, while the other is newer and not so well understood. In such cases, the former is called the direct problem, while the latter is called the inverse problem. ' 'The main sources of inverse problems are science and engineering. Often these problems concern the determination of the properties of some inaccess ible regions from observations on the boundary of that region. ' Often, inverse problems are not well posed. This increases the difficulty in their analysis and numerical solution. As can be seen from the table of content of this volume, the conference covered inverse problems in scattering theory, seismology, tomography, estimation of coefficients and source terms in parabolic and elliptic differential equations, the inverse Sturm-Liouville problem, and numerical methods. The editors wish to thank Professor M. Barner and his co-workers of the Mathematical Research Institute for their help in creating the conference. 192 pp. Englisch.

Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Das Unendliche hat wie keine andere Frage von jeher so tief das Gemüt der Menschen bewegt,' das Unendliche hat wie kaum eine andere Idee auf den Verstand so an regend und fruchtbar gewirkt,' das Unendliche ist aber auch wie kein anderer Begriff so der Aufklärung bedürftig. HILBERT [226, p. 163] Etwas mehr als 100 Jahre sind vergangen, seit in den Mathemati schen Annalen der sechste und letzte Teil von CANTORS fundamenta ler Arbeit Über unendliche lineare Punktmannichfaltigkeiten erschie nen ist. Damit war die Mengenlehre geboren und mit ihr eine prinzipiell neue Auffassung des Unendlichen in der Mathematik, verkörpert in CANTORS Theorie der transfiniten Zahlen. Diese Theo rie hat HILBERT als «die bewundernswerteste Blüte mathematischen Geistes und überhaupt eine der höchsten Leistungen rein verstandes mäßiger menschlicher Tätigkeit» bezeichnet. Anfangs unbeachtet oder abgelehnt, zu Ende des vorigen Jahrhunderts zunehmend anerkannt und verwendet, durch die Ent deckung der Antinomien erneut erschüttert, ist die Mengenlehre in ihrer heutigen axiomatisierten Gestalt eines der Fundamente der Mathematik. Die Tatsache, daß alle mathematischen Begriffe auf mengentheoretische Begriffe zurückgeführt werden können, hat ei nige Autoren sogar zu der Behauptung veranlaßt, die gesamte Ma thematik sei letztendlich mit der Mengenlehre identisch. Wenn uns allerdings eine solche Ansicht als eine ungerechtfertigte Überbeto nung des Formalen gegenüber dem Inhaltlichen erscheint, so ist doch unbestritten, daß die mengentheoretische Durchdringung der Mathematik neben der Entstehung des strukturellen Denkens und der Verwendung der axiomatischen Methode ein Wesenszug der mo dernen Mathematik ist. Das hat in zahlreichen Ländern bis in denSchulunterricht hinein gewirkt. 262 pp. Deutsch.

Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -K. Sikora Gene therapy is one of the fastest developing areas in modern medical research. Transcending the classical preclinical and clinical disciplines, it is likely to have far reaching consequences in the practice of medicine, as we enter the next millennium. Currently, there are over 200 seperate active clinical trials with over 2,500 patients entered. These studies involve over 20 countries and include patients with a wide range of diseases, including cancer, HIV infection; cystic fibrosis (CF), haemophilia, diabetes, immune deficiencies, metabolic disorders, ischaemic heart disease and arthritis. Gene therapy can be defined as the deliberate transfer of DNA for therapeutic purposes. There is a further implication that only specific sequences containing rel evant genetic information are used; otherwise, transplantation procedures involving bone marrow, kidney or liver could be considered a form of gene therapy. The con cept of transfer of genetic information as a practical clinical tool arose from the gene-cloning technology, developed during the 1970s. Without the ability to isolate and replicate defined genetic sequences, it would be impossible to produce purified material for clinical use. The drive for the practical application of this technology came from the biotechnology industry with its quest for complex human biomole cules produced by recombinant techniques in bacteria. Within a decade, pharma ceutical-grade insulin, interferon, interleukin 2 and tumour necrosis factor were all involved in clinical trials. The next step was to obtain gene expression in vivo.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 396 pp. Englisch.