nature publishing group (122 resultados)

Paper Back. Condición: Acceptable.

Condición: good. Befriedigend/Good: Durchschnittlich erhaltenes Buch bzw. Schutzumschlag mit Gebrauchsspuren, aber vollständigen Seiten. / Describes the average WORN book or dust jacket that has all the pages present.

Hardcover. Condición: Very Good. Estado de la sobrecubierta: No DJ. First Edition, First Printing. From a technical company with their stamps, otherwise a VG hardcover first edition, first printing copy, no DJ, slick blue binding.

Condición: Good. Most items will be dispatched the same or the next working day. A copy that has been read but remains in clean condition. All of the pages are intact and the cover is intact and the spine may show signs of wear. The book may have minor markings which are not specifically mentioned.

Paperback. Condición: Very Good. Unmarked text. Features Cancer Stem Cell Function. Also submarien volcanoes, breaking Mendel's Law, what is a gene, and more. No. 7092, pp.483-548.

Paperback. Condición: Very Good. Unmarked text. Features Venus Express. Also geroscience: can old age be healthy, Diabetes drugs, gatekeeper of the nucleus, and more. 29 November 2007, No. 450, pp 585-760.

Paperback. Condición: Used; Very Good. **SHIPPED FROM UK** We believe you will be completely satisfied with our quick and reliable service. All orders are dispatched as swiftly as possible! Buy with confidence! Greener Books.

Paperback. Condición: Used; Good. **SHIPPED FROM UK** We believe you will be completely satisfied with our quick and reliable service. All orders are dispatched as swiftly as possible! Buy with confidence! Greener Books.

Condición: Poor. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In poor condition, suitable as a reading copy. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,2300grams, ISBN:9780333723067.

Condición: Fair. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. Clean from markings. In fair condition, suitable as a study copy. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,2250grams, ISBN:9780333723067.

Soft cover. Condición: Near Fine. A lovely copy of this scarce issue! Clean and bright -- no markings of any kind. Cover story, "Bee Line: Beeswax Traces in Pottery Vessels Date Human Use of Hive Products to the Beginnings of Agriculture." Ships from NC. (J-6.).

hardcover. Condición: Good. Connecting readers with great books since 1972! Used textbooks may not include companion materials such as access codes, etc. May have some wear or writing/highlighting. We ship orders daily and Customer Service is our top priority!

hardcover. Condición: Acceptable. Connecting readers with great books since 1972. Used textbooks may not include companion materials such as access codes, etc. May have condition issues including wear and notes/highlighting. We ship orders daily and Customer Service is our top priority!

Condición: Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,2950grams, ISBN:9780333792124.

Soft cover. Condición: New. 1st Edition. New; Fine. See description and scans. New York: Nature Publishing Group, 2011. The 17 March, 2011 issue, Volume 471, Issue No. 7338, of Nature: The International Weekly Journal of Science. Quarto, illustrated perfect-bound wraps, 140 pp. New; Fine. The inevitable trace micro-edgewear from the rack, else flawless. Unperused except for scanning and description. No labels either, of course. See scans. How so many pages of such a technically and semi-technically rich compendium of text and graphics on such a wide variety of topics can be put together every week remains a mystery, here. They do charge a healthy fee for it, but it's worth it. Articles are as diversified as always - and include the inevitable politicizing in some (not too many) - but see the scans of the contents pages for a better idea. Even each "Letter" is in fact a scholarly work by multiple scientists and technical experts (see sample). An interdisciplinary scientific masterwork since 1869, Nature was, in 2010, named the most-cited scientific journal - period. More fascination per page than pretty much any other printed source. See scans for just a taste. LPR18.

Soft cover. Condición: New. 1st Edition. New; Fine. See description and scans. New York: Nature Publishing Group, 2011. The 29 November, 2012 issue, Volume 491, Issue No. 7426, of Nature: The International Weekly Journal of Science. Quarto, illustrated perfect-bound wraps, 158 pp. New; Fine. The inevitable trace micro-edgewear from the rack, else flawless. Unperused except for scanning and description. No labels either, of course. See scans. How so many pages of such a technically and semi-technically rich compendium of text and graphics on such a wide variety of topics can be put together every week remains a mystery, here. They do charge a healthy fee for it, but it's worth it. Articles are as diversified as always - and include the inevitable politicizing in some (not too many) - but see the scans of the contents pages for a better idea. Even each "Letter" is in fact a scholarly work by multiple scientists and technical experts (see sample). An interdisciplinary scientific masterwork since 1869, Nature was, in 2010, named the most-cited scientific journal - period. More fascination per page than pretty much any other printed source. See scans for just a taste. LPR18.

Soft cover. Condición: New. 1st Edition. New; Fine. See description and scans. New York: Nature Publishing Group, 2011. The 24 February, 2011 issue, Volume 470, Issue No. 7335, of Nature: The International Weekly Journal of Science. Quarto, illustrated perfect-bound wraps, 138 pp. New; Fine. The inevitable trace micro-edgewear from the rack, else flawless. Unperused except for scanning and description. No labels either, of course. See scans. How so many pages of such a technically and semi-technically rich compendium of text and graphics on such a wide variety of topics can be put together every week remains a mystery, here. They do charge a healthy fee for it, but it's worth it. Articles are as diversified as always - and include the inevitable politicizing in some (not too many) - but see the scans of the contents pages for a better idea. Even each "Letter" is in fact a scholarly work by multiple scientists and technical experts (see sample). An interdisciplinary scientific masterwork since 1869, Nature was, in 2010, named the most-cited scientific journal - period. More fascination per page than pretty much any other printed source. See scans for just a taste. LPR18.

Soft cover. Condición: New. 1st Edition. New; Fine. See description and scans. New York: Nature Publishing Group, 2011. The 7 April, 2011 issue, Volume 472, Issue No. 7341, of Nature: The International Weekly Journal of Science. Quarto, illustrated perfect-bound wraps, 130 pp. New; Fine. Top right cover corner micro-touched (see scan), nonetheless New. Unperused except for scanning and description. No labels either, of course. See scans. How so many pages of such a technically and semi-technically rich compendium of text and graphics on such a wide variety of topics can be put together every week remains a mystery, here. They charge a healthy fee for it, but it's worth it. Articles are as diversified as always - and include the inevitable politicizing in some (not too many) - but see the scans of the contents pages for a better idea. Even each "Letter" is in fact a scholarly work by multiple scientists and technical experts (see sample). An interdisciplinary scientific masterwork since 1869, Nature was, in 2010, named the most-cited scientific journal - period. More fascination per page than pretty much any other printed source. See scans for just a taste. LPR18.

Soft cover. Condición: New. 1st Edition. New; Fine. See description and scans. New York: Nature Publishing Group, 2011. The 24 March, 2011 issue, Volume 471, Issue No. 7339, of Nature: The International Weekly Journal of Science. Quarto, illustrated perfect-bound wraps, 140 pp. New; Fine. Unperused except for scanning and description. No labels either, of course. See scans. How so many pages of such a technically and semi-technically rich compendium of text and graphics on such a wide variety of topics can be put together every week remains a mystery, here. They do charge a healthy fee for it, but it's worth it. Articles are as diversified as always - and include the inevitable politicizing in some (not too many) - but see the scans of the contents pages for a better idea. Even each "Letter" is in fact a scholarly work by multiple scientists and technical experts (see sample). An interdisciplinary scientific masterwork since 1869, Nature was, in 2010, named the most-cited scientific journal - period. More fascination per page than pretty much any other printed source. See scans for just a taste. LPR18.

Soft cover. Condición: New. 1st Edition. New; Fine. See description and scans. New York: Nature Publishing Group, 2011. The 10 March, 2011 issue, Volume 471, Issue No. 7337, of Nature: The International Weekly Journal of Science. Quarto, illustrated perfect-bound wraps, 130 pp. New; Fine. Unperused except for scanning and description. No labels either, of course. See scans. How so many pages of such a technically and semi-technically rich compendium of text and graphics on such a wide variety of topics can be put together every week remains a mystery, here. They do charge a healthy fee for it, but it's worth it. Articles are as diversified as always - and include the inevitable politicizing in some (not too many) - but see the scans of the contents pages for a better idea. Even each "Letter" is in fact a scholarly work by multiple scientists and technical experts (see sample). An interdisciplinary scientific masterwork since 1869, Nature was, in 2010, named the most-cited scientific journal - period. More fascination per page than pretty much any other printed source. See scans for just a taste. LPR18.

Soft cover. Condición: New. 1st Edition. New; Fine. See description and scans. New York: Nature Publishing Group, 2013. The 24 January, 2013 issue, Volume 494, Issue No. 7433, of Nature: The International Weekly Journal of Science. Quarto, illustrated perfect-bound wraps, 124 pp. New; Fine. Unperused except for scanning and description. No labels either, of course. See scans. How so many pages of such a technically and semi-technically rich compendium of text and graphics on such a wide variety of topics can be put together every week remains a mystery, here. They do charge a healthy fee for it, but it's worth it. Articles are as diversified as always - and include the inevitable politicizing in some (not too many) - but see the scans of the contents pages for a better idea. Even each "Letter" is in fact a scholarly work by multiple scientists and technical experts (see sample). An interdisciplinary scientific masterwork since 1869, Nature was, in 2010, named the most-cited scientific journal - period. More fascination per page than pretty much any other printed source. See scans for just a taste. LPR18.

Soft cover. Condición: New. 1st Edition. New; Fine. See description and scans. New York: Nature Publishing Group, 2014. The 6 November, 2014 issue, Volume 515, Issue No. 7525, of Nature: The International Weekly Journal of Science. Quarto, illustrated perfect-bound wraps, 156 pp. New; Fine. Unperused except for scanning and description. See scans. With laid-in promo flier for the King Abdullah International Medical Research Center (scan).; also, tipped on front cover is a promo card for the first edition of the CST Guide by cellsignal - a new reference by that cellular research organization. How so many pages of such a technically and semi-technically rich compendium of text and graphics on such a wide variety of topics can be put together every week remains a mystery, here. They do charge a healthy fee for it, but it's worth it. Articles are as diversified as always - and, these days, include the inevitable politicizing in some - but see the scans of the contents pages for an idea. Even each "Letter" is in fact a scholarly work by a dozen or more scientists and technical experts (see sample). An interdisciplinary scientific masterwork since 1869, Nature was, in 2010, named the most-cited scientific journal - period. More fascination per page than pretty much any other printed source. See scans for just a taste. LPR7.

Soft cover. Condición: Fine. 1st Edition. Fine; see description and scans. New York: Nature Publishing Group, 2014. The 10 July, 2014 issue, Volume 511, Issue No. 7508, of Nature: The International Weekly Journal of Science. Quarto, illustrated perfect-bound wraps, 140 pp. Fine, as received new, unperused except for scanning and description. See scans. How so many pages of such a technically and semi-technically rich compendium of text and graphics on such a wide variety of topics can be put together every week remains a mystery, here. They do charge a healthy fee for it, but it's worth it. Articles are as diversified as always - and, these days, include the inevitable politicizing in some - but see the scans of the contents pages for an idea. Even each "Letter" is in fact a scholarly work by a dozen or more scientists and technical experts (see sample). An interdisciplinary scientific masterwork since 1869, Nature was, in 2010, named the most-cited scientific journal - period. More fascination per page than pretty much any other printed source. See scans for just a taste. LPR6.

Soft cover. Condición: New. 1st Edition. New; see description and scans. New York: Nature Publishing Group, 2014. The May 1, 2014 issue, Volume 509, Issue No. 7498, of Nature: The International Weekly Journal of Science. Quarto, illustrated perfect-bound wraps, 128 pp. New; pristine. See scans of both covers. Contents are, of course, Fine as well. How so many pages of such a technically and semi-technically rich compendium of text and graphics on such a wide variety of topics can be put together every week remains a mystery, here. They do charge a healthy fee for it, but it's worth it. Articles are as diversified as always - and, these days, include the inevitable politicizing in some - but see the scans of the contents pages for an idea. Even each "Letter" is in fact a scholarly work by a dozen or more scientists and technical experts (see sample). An interdisciplinary scientific masterwork since 1869, Nature was, in 2010, named the most-cited scientific journal - period. More fascination per page than pretty much any other printed source. See scans for just a taste. LPR6.

Condición: New. 1995. 1996th Edition. Paperback. . . . . .

Hardcover. Condición: Good. No Jacket. Slight edge wear and odd age mark, otherwise very good condition. Heavy book, extra postage may apply.

Policy: Bring sustainable energy to the developing world Investment and policies must support cheap, clean energy technologies to cut both poverty and climate change, say Reid Detchon and Richenda Van Leeuwen. Publishing: Credit where credit is due Liz Allen, Amy Brand, Jo Scott, Micah Altman and Marjorie Hlava are trialling digital taxonomies to help researchers to identify their contributions to collaborative projects. Astronomy: Art of the eclipse As the next solar eclipse approaches, Jay M. Pasachoff and Roberta J. M. Olson ponder how artists from the early Renaissance onwards have interpreted the phenomenon. Geology: Parsing eruptions Ted Nield weighs up histories of two momentous volcanic events in Iceland and Indonesia. Review of Island on Fire: The Extraordinary Story of Laki: The Volcano That Turned Eighteenth-Century Europe Dark Tambora: The Eruption That Changed the World Alexandra Witze, Jeff Kanipe & Gillen D'Arcy Wood Animal behaviour: Nomads of necessity Joel Greenberg casts an ornithologist's eye on a wide-ranging reading of animal migration. Review of The Homing Instinct: Meaning and Mystery in Animal Migration Bernd Heinrich Obesity Tony Scully Society at large Tony Scully Cell physiology: The changing colour of fat Brian Owens Treatment: Marginal gains Emily Anthes Perspective: Obesity is not a disease D. L. Katz Heritability: The family roots of obesity Cassandra Willyard Microbiome: A complicated relationship status Sarah Deweerdt Neuroscience: Dissecting appetite Bijal P. Trivedi Perspective: Tricks of the trade Stephen J. Simpson & David Raubenheimer Evolutionary biology: Dating chimpanzees Michael Haslam Genetics: Up and down in Down's syndrome Benjamin D. Pope & David M. Gilbert See also Article by Letourneau et al. Organic chemistry: Catalysis marches on James P. Morken See also Article by Mei et al. Synthetic biology: Biocircuits in synchrony Ricard Solé & Javier Macía See also Letter by Prindle et al. Thermoelectricity: The ugly duckling Joseph P. Heremans See also Letter by Zhao et al. Review Top The ensemble nature of allostery Hesam N. Motlagh, James O. Wrabl, Jing Li & Vincent J. Hilser Allostery is the process by which biological macromolecules transmit the effect of binding at one site to another, often distal, functional site, allowing for the regulation of activity; here facilitation of allostery through dynamic and intrinsically disordered proteins is discussed, and a framework to unify the description of allosteric mechanisms for different systems is proposed. Articles Top Enantioselective construction of remote quaternary stereocentres Tian-Sheng Mei, Harshkumar H. Patel & Matthew S. Sigman A catalytic and enantioselective intermolecular Heck-type reaction of trisubstituted-alkenyl alcohols with aryl boronic acids provides direct access to quaternary stereocentres remote from a carbonyl group. See also News & Views by Morken Domains of genome-wide gene expression dysregulation in Down?s syndrome Audrey Letourneau, Federico A. Santoni, Ximena Bonilla, M. Reza Sailani, David Gonzalez + et al. By studying the transcriptome of fetal cells of monozygotic twins discordant for trisomy 21, this paper finds that differential expression between the twins is organized in domains along all chromosomes; these gene expression dysregulation domains are conserved in the mouse model of Down?s syndrome and correlate with the lamina-associated domains and replication domains. See also News & Views by Pope & Gilbert Brainstem nucleus MdV mediates skilled forelimb motor tasks Maria Soledad Esposito, Paolo Capelli & Silvia Arber The authors use a combination of viral tracing and genetics to characterize the diversity of neurons projecting from mouse brainstem to motor neurons that control limb movements; in particular they discover that the medullary reticular formation ventral part (MdV) is functionally specialized for skilled forelimb motor control. Skilled reaching relies on a V2a propriospinal internal copy circuit Eiman Azim, Juan Jiang, Bror Alstermark & Thomas M. Jessell Cervical propriospinal neurons (PNs) form a genetically accessible subclass of V2a interneurons that convey both premotor output and precerebellar copy signals; their ablation in mice impairs reaching movements selectively, and activation of their internal copy projection recruits a rapid cerebellar feedback loop that modulates forelimb movement. Letters Top Isotopic links between atmospheric chemistry and the deep sulphur cycle on Mars Heather B. Franz, Sang-Tae Kim, James Farquhar, James M. D. Day, Rita C. Economos + et al. Isotopic analyses of 40 Martian meteorites indicate that assimilation of sulphur into Martian magmas was a common occurrence throughout much of the planet?s history and that the atmospheric imprint of photochemical processing preserved in Martian meteoritic sulphide and sulphate is distinct from that observed in terrestrial analogues. Coherent suppression of electromagnetic dissipation due to superconducting quasiparticles Ioan M. Pop, Kurtis Geerlings, Gianluigi Catelani, Robert J. Schoelkopf, Leonid I. Glazman + et al. The long-predicted suppression of quasiparticle dissipation in a Josephson junction when the phase difference across the junction is ? is inferred from a sharp maximum in the energy relaxation time of a superconducting artificial atom. Ultralow thermal conductivity and high thermoelectric figure of merit in SnSe crystals Li-Dong Zhao, Shih-Han Lo, Yongsheng Zhang, Hui Sun, Gangjian Tan + et al. The main obstacle to improving the thermoelectric efficiency of a material arises from the common interdependence of electrical and thermal conductivity, whereas one ideally wants to raise the former while lowering the latter: a simple layered crystalline material ? SnSe ? is now reported that seems to have these qualities built in. See also News & Views by Heremans Mid-latitude interhemispheric hydrologic seesaw over the past 550,000 years Kyoung-nam Jo, Kyung Sik Woo.

Medical research: Missing patients Effective clinical studies must consider all ethnicities ? exclusion can endanger populations, says Esteban G. Burchard. Developing world: Discuss inequality Confront economic differences to strengthen global research, urge P. Wenzel Geissler and Ferdinand Okwaro. Mental health: Tailor informed-consent processes The first step in studying mental-health interventions across cultures is to adjust procedures to participants' needs, says Mónica Ruiz-Casares. Collaboration: Strength in diversity Richard B. Freeman and Wei Huang reflect on a link between a team's ethnic mix and highly cited papers. Genetics: Under the skin Nathaniel Comfort wonders at the enduring trend of misrepresenting race. Review of A Troublesome Inheritance: Genes, Race and Human History, Race Unmasked: Biology and Race in the 20th Century & The Myth of Race: The Troubling Persistence of an Unscientific Idea Nicholas Wade, Michael Yudell & Robert Wald Sussman Physics: In thrall to uncertainty A history of how quantum theory has permeated Western culture refreshes Jim Baggott. Review of The Quantum Moment: How Planck, Bohr, Einstein, and Heisenberg Taught Us to Love Uncertainty Robert P. Crease & Alfred Scharff Goldhaber New in paperback Linguistics: The write stuff Steven Pinker's provocative treatise on language use and abuse would benefit from more data, finds Paul Raeburn. Review of The Sense of Style: The Thinking Person's Guide to Writing in the 21st Century Steven Pinker Evolution: Tribes like us Tim Lenton is intrigued by E. O. Wilson's sweeping perspective on humanity's past ? and possible futures. Review of The Meaning of Human Existence Edward O. Wilson Climate policy: A societal sea change Nico Stehr ponders Naomi Klein's call for strategic mass action on climate change. Review of This Changes Everything: Capitalism vs the Climate Naomi Klein Internet: Technology and its discontents Jaron Lanier surveys four studies probing the vexed nexus of mind and digisphere. Review of Mind Change: How Digital Technologies Are Leaving Their Mark on Our Brains, The Organized Mind: Thinking Straight in the Age of Information Overload, The Impulse Society: What's Wrong With Getting What We Want? & The Glass Cage: Automation and Us Susan Greenfield, Daniel J. Levitin, Paul Roberts & Nicholas Carr When disease strikes from nowhere When healthy parents have a child with a genetic disorder, the cause is sometimes a new mutation. Tools are emerging to meet the challenge of finding such changes. Insight: Exoplanets Exoplanets Leslie Sage Doppler spectroscopy as a path to the detection of Earth-like planets Michel Mayor, Christophe Lovis & Nuno C. Santos See also Insight by Lissauer et al. See also Insight by Pepe et al. Advances in exoplanet science from Kepler Jack J. Lissauer, Rebekah I. Dawson & Scott Tremaine Highlights in the study of exoplanet atmospheres Adam S. Burrows The role of space telescopes in the characterization of transiting exoplanets Artie P. Hatzes See also Insight by Lissauer et al. Instrumentation for the detection and characterization of exoplanets Francesco Pepe, David Ehrenreich & Michael R. Meyer See also Insight by Mayor et al. GATM locus does not replicate in rhabdomyolysis study James S. Floyd, Joshua C. Bis, Jennifer A. Brody, Susan R. Heckbert, Kenneth Rice + et al. Mangravite et al. reply Lara M. Mangravite, Barbara E. Engelhardt, Matthew Stephens & Ronald M. Krauss News & Views Top Evolutionary biology: Radiating genomes Chris D. Jiggins See also Article by Brawand et al. Condensed-matter physics: Catching relativistic electrons Zhihuai Zhu & Jennifer E. Hoffman Animal behaviour: The evolutionary roots of lethal conflict Joan B. Silk See also Letter by Wilson et al. Astrophysics: Giant black hole in a stripped galaxy Amy E. Reines See also Letter by Seth et al. 50 & 100 Years Ago Neuroscience: Shedding light on a change of mind Tomonori Takeuchi & Richard G. M. Morris See also Letter by Redondo et al. Organic chemistry: Reactivity tamed one bond at a time Matthew T. Villaume & Phil S. Baran See also Article by Meng et al. Articles Top Multifunctional organoboron compounds for scalable natural product synthesis Fanke Meng, Kevin P. McGrath & Amir H. Hoveyda A catalytic process is reported that begins with a highly selective copper?boron addition to a monosubstituted allene, and in which the resulting boron-substituted organocopper intermediate then participates in a chemoselective, site-selective and enantioselective allylic substitution; this approach is used in the enantioselective synthesis of gram quantities of two natural products. See also News & Views by Villaume & Baran The genomic substrate for adaptive radiation in African cichlid fishOpen David Brawand, Catherine E. Wagner, Yang I. Li, Milan Malinsky, Irene Keller + et al. Genomes and transcriptomes of five distinct lineages of African cichlids, a textbook example of adaptive radiation, have been sequenced and analysed to reveal that many types of molecular changes contributed to rapid evolution, and that standing variation accumulated during periods of relaxed selection may have primed subsequent diversification. See also News & Views by Jiggins Proteogenomic characterization of human colon and rectal cancer Bing Zhang, Jing Wang, Xiaojing Wang, Jing Zhu, Qi Liu + et al. Proteome analysis of The Cancer Genome Atlas (TCGA) colorectal cancer specimens reveals that DNA- or RNA-level measurements cannot reliably predict protein abundance, colorectal tumours can be separated into distinct proteotypes, and that copy number alterations drive mRNA abundance changes but few extend to protein-level changes. Molecular architecture and mechanism of the anaphase-promoting complex Leifu Chang, Ziguo Zhang, Jing Yang, Stephen H. McLaughlin & David Barford The anaphase-promoting complex/cyclosome (APC/C) is a large E3 ligase that mediates ubiquitin-dependent proteolysis of cell cycle regulatory proteins; here the compl.

Mental health: A road map for suicide research and prevention It is time for policy-makers, funders, researchers and clinicians to tackle high suicide rates, say André Aleman and Damiaan Denys. Evolutionary biology: Darwin and the women Sarah S. Richardson relishes a study of how nineteenth-century US feminists used the biologist's ideas. Review of From Eve to Evolution: Darwin, Science, and Women's Rights in Gilded Age America Kimberly A. Hamlin Information technology: Forgotten prophet of the Internet Philip Ball ponders the tale of a librarian who dreamed of networking information. Review of Cataloging the World: Paul Otlet and the Birth of the Information Age Alex Wright European pollution: Investigate smog to inform policy Paul S. Monks Databases: Soil observatory lets researchers dig deep Russell Lawley, Bridget A. Emmett & David A. Robinson Health care: Strict vaccine quality control in China Zhenglun Liang, Qunying Mao & Junzhi Wang Political ecology: Rethink Campania's toxic-waste scandal Giacomo D'Alisa, Marco Armiero & Salvatore Paolo De Rosa Technology: Internal factors drive Chinese patent surge Ching-Yan Wu, Mei-Chih Hu & John A. Mathews Epigenetics: Keeping one's sex Douglas L. Chalker See also Article by Singh et al. Astrophysics: Windy stars that go with a bang John J. Eldridge See also Letter by Gal-Yam et al. Physiology: Double function at the blood?brain barrier Christer Betsholtz See also Letter by Nguyen et al. See also Letter by Ben-Zvi et al. Materials chemistry: Selectivity from flexibility Ryotaro Matsuda Cancer: Darwinian tumour suppression Eduardo Moreno See also Article by Martins et al. Earth science: Fertile fields for seismicity Paul Lundgren See also Letter by Amos et al. Articles Top Genome-defence small RNAs exapted for epigenetic mating-type inheritance Deepankar Pratap Singh, Baptiste Saudemont, Gérard Guglielmi, Olivier Arnaiz, Jean-François Goût + et al. The molecular basis for mating-type determination in the ciliate Paramecium has been elucidated, revealing a novel function for a class of small RNAs ? these scnRNAs are typically involved in reprogramming the Paramecium genome during sexual reproduction by recognizing and excising transposable elements, but they are now found to be co-opted to switch off expression of the newly identified mating-type gene mtA by excising its promoter, and to mediate epigenetic inheritance of mating types across sexual generations. See also News & Views by Chalker Amygdala interneuron subtypes control fear learning through disinhibition Steffen B. E. Wolff, Jan Gründemann, Philip Tovote, Sabine Krabbe, Gilad A. Jacobson + et al. Plasticity within neuronal microcircuits is believed to be the substrate of learning, and this study identifies two distinct disinhibitory mechanisms involving interactions between PV+ and SOM+ interneurons that dynamically regulate principal neuron activity in the amygdala and thereby control auditory fear learning. Contrasting forms of cocaine-evoked plasticity control components of relapse Vincent Pascoli, Jean Terrier, Julie Espallergues, Emmanuel Valjent, Eoin Cornelius O?Connor + et al. Information integration in the nucleus accumbens is commandeered by cocaine at discrete synapses to allow relapse. Cell competition is a tumour suppressor mechanism in the thymus Vera C. Martins, Katrin Busch, Dilafruz Juraeva, Carmen Blum, Carolin Ludwig + et al. T cells develop from thymic precursor cells that are constantly replaced with newly arriving bone marrow progenitor cells, and the ?old? and ?new? cells are shown here to compete; in the absence of cell competition, when the influx of new bone marrow progenitor cells is blocked, the old cells acquire the ability to self-renew and eventually become transformed, leading to the development of a form of leukaemia. See also News & Views by Moreno Letters Top A Wolf?Rayet-like progenitor of SN 2013cu from spectral observations of a stellar wind Avishay Gal-Yam, I. Arcavi, E. O. Ofek, S. Ben-Ami, S. B. Cenko + et al. The detection of strong emission lines in an early-time spectrum of type IIb supernova SN 2013cu reveals Wolf?Rayet-like wind signatures, suggesting that the supernova?s progenitor may have been a Wolf?Rayet star with a wind dominated by helium and nitrogen, with traces of hydrogen. See also News & Views by Eldridge Practical quantum key distribution protocol without monitoring signal disturbance Toshihiko Sasaki, Yoshihisa Yamamoto & Masato Koashi Conventional quantum cryptography relies on monitoring signal disturbance to make sure that information leakage is negligible; here a new quantum method of achieving security is described, in which little information is leaked to the eavesdropper regardless of the signal disturbance. Future increases in Arctic precipitation linked to local evaporation and sea-ice retreat R. Bintanja & F. M. Selten Precipitation is expected to increase far more over the twenty-first century in the Arctic than the global average; climate models show that this is driven mainly by increased local evaporation and sea-ice retreat, rather than by increased moisture transport from lower latitudes. Uplift and seismicity driven by groundwater depletion in central California Colin B. Amos, Pascal Audet, William C. Hammond, Roland Bürgmann, Ingrid A. Johanson + et al. Human-caused groundwater depletion in California?s San Joaquin Valley contributes to uplift of the surrounding mountains and may affect the stability of the San Andreas Fault. See also News & Views by Lundgren High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells Yuexin Zhou, Shiyou Zhu, Changzu Cai, Pengfei Yuan, Chunmei Li + et al. This study describes the construction of a focused CRISPR/Cas-based lentiviral library in human cells and a method of gene identification based on functional screening and high-throughput sequencing analysis. Copper is required for oncogenic BRAF signalling and tumorigenesis Donita C. Brady, M.

Climate science: Understand Arctic methane variability Expand ground monitoring of polar sources of this greenhouse gas to find out how climate change will influence its release, says Torben R. Christensen. Policy: NIH to balance sex in cell and animal studies Janine A. Clayton and Francis S. Collins unveil policies to ensure that preclinical research funded by the US National Institutes of Health considers females and males. Sociobiology: The distributed brain Herbert Gintis salutes the follow-up to a study on sociality and hominin brain size. Review of Thinking Big: How the Evolution of Social Life Shaped the Human Mind Clive Gamble, John Gowlett & Robin Dunbar Books in brief Chemistry: Intoxicating science Jamie Goode drinks in two views of that most venerable and destructive drug ? alcohol. Review of Proof: The Science of Booze & The Drunken Monkey: Why We Drink and Abuse Alcohol Adam Rogers & Robert Dudley Development: Dammed dreams Monya Baker is swept along by a documentary film tracing humanity's complex relationship with water. Review of Watermark Edward Burtynsky & Jennifer Baichwal Climate science: Shifting storms Hamish Ramsay See also Letter by Kossin et al. Synthetic biology: New letters for life's alphabet Ross Thyer & Jared Ellefson See also Letter by Malyshev et al. Organic chemistry: Collaborative synthesis John L. Wood See also Article by Mercado-Marin et al. Neurobiology: To care or not to care Ivan Rodriguez See also Article by Wu et al. 50 & 100 Years Ago Sensory biology: Radio waves zap the biomagnetic compass Joseph L. Kirschvink See also Letter by Engels et al. Evolution: Geology and climate drive diversification Rosemary G. Gillespie & George K. Roderick Articles Top Total synthesis and isolation of citrinalin and cyclopiamine congeners Eduardo V. Mercado-Marin, Pablo Garcia-Reynaga, Stelamar Romminger, Eli. F. Pimenta, David K. Romney + et al. Natural products citrinalin B and cyclopiamine B, which contain basic nitrogen atoms that are susceptible to oxidation during synthesis, can be synthesized by the selective introduction and removal of functional groups. See also News & Views by Wood Galanin neurons in the medial preoptic area govern parental behaviour Zheng Wu, Anita E. Autry, Joseph F. Bergan, Mitsuko Watabe-Uchida & Catherine G. Dulac Sexual experience brings radical changes in how male mice behave with pups?virgin males attack them whereas mature fathers display parental care; here the authors identify a subset of hypothalamic neurons whose ablation leads to parental deficits in both males and females, and whose activation in virgin males suppresses aggression and induces pup grooming. See also News & Views by Rodriguez Space?time wiring specificity supports direction selectivity in the retina Jinseop S. Kim, Matthew J. Greene, Aleksandar Zlateski, Kisuk Lee, Mark Richardson + et al. Motion detection by the retina is thought to rely largely on the biophysics of starburst amacrine cell dendrites; here machine learning is used with gamified crowdsourcing to draw the wiring diagram involving amacrine and bipolar cells to identify a plausible circuit mechanism for direction selectivity; the model suggests similarities between mammalian and insect vision. c-kit+ cells minimally contribute cardiomyocytes to the heart Jop H. van Berlo, Onur Kanisicak, Marjorie Maillet, Ronald J. Vagnozzi, Jason Karch + et al. Whether or not endogenous c-kit+ cells residing within the heart contribute cardiomyocytes during physiological ageing or after injury remains unknown; here, using an inducible lineage tracing system, the c-kit+ lineage is shown to generate cardiomyocytes at very low levels, and, by contrast, contributes substantially to cardiac endothelial cell generation. Letters Top Cepheid variables in the flared outer disk of our galaxy Michael W. Feast, John W. Menzies, Noriyuki Matsunaga & Patricia A. Whitelock Five classical Cepheids have been detected in the outer parts of our Galaxy beyond the Galactic bulge; they are probably associated with the gas in the flared disk and, if so, they are the first stars to be identified in the flare. Tracking excited-state charge and spin dynamics in iron coordination complexes Wenkai Zhang, Roberto Alonso-Mori, Uwe Bergmann, Christian Bressler, Matthieu Chollet + et al. Femtosecond resolution X-ray fluorescence spectroscopy is shown to track the charge and spin dynamics triggered when an iron coordination complex is excited by light, and establishes the critical role of intermediate spin states in the de-excitation process. The poleward migration of the location of tropical cyclone maximum intensity James P. Kossin, Kerry A. Emanuel & Gabriel A. Vecchi Analysis of global historical data in the Northern and Southern hemispheres reveals a statistically significant, poleward migration of 1° per decade in the average latitude at which tropical cyclones have achieved their lifetime-maximum intensity over the past 30 years. See also News & Views by Ramsay Anthropogenic electromagnetic noise disrupts magnetic compass orientation in a migratory bird Svenja Engels, Nils-Lasse Schneider, Nele Lefeldt, Christine Maira Hein, Manuela Zapka + et al. For the first time under reproducible and fully double-blinded conditions, it is shown that anthropogenic electromagnetic noise below the WHO limits affects a biological system: night-migrating birds lose the ability to use the Earth?s magnetic field for orientation when exposed to anthropogenic electromagnetic noise at strengths routinely produced by commonly used electronic devices. See also News & Views by Kirschvink Dynamics and associations of microbial community types across the human body Tao Ding & Patrick D. Schloss The microbiome composition of 300 individuals sampled over 12?18 months was partitioned into microbial community types, which could be associated with the type found at other body sites, as well as with whether individuals were breastfed as an infant, their gender and thei.