elsevier science aug 1995 (4 resultados)

Buch. Condición: Neu. Neuware - The incentive for putting together Volume 4 of this series was to review the wealth of new information that has become available in prokaryotic organisms in protein export and membrane biogenesis. Just in the last several years, protein translocation has now been efficiently reconstituted using defined components and the mechanism by which proteins are moved across membrane bilayers is now being examined at a higher resolution. In addition, because of a new technical breakthrough using osmolytes, it is now possible to reconstitute a number of channel proteins, ATPase, receptors, and transporters. In many cases, it is possible to successfully predict the membrane topology of these types of proteins using both 'hydrophobicity analysis' and the 'positive inside' rule. In this volume, two chapters focus on protein translocation across membranes (Biochemical Analyses of Components Comprising the Protein Translocation Machinery of E. Coli; Protein Translocation Genetics), while several others on how proteins assemble into the ineer membrane of E. Coli (Membrane Protein Assembly; Membrane Insertion of Small Proteins: Evolutionary and Functional Aspects; Pigment-Protein Complex Assembly in Rhodobacter sphaeroides and Rhodobacter Capsulatus). Other sections review recent progress on transporters (Identification and Reconstitution of Anion Exchange Mechanisms in Bacteria; Helic Packing in the C-Terminal Half of Lactose Permease) and signal transduction (Mechanism of Transmembrane Signaling in Osmoregulation) as well as the assembly of prints into the outer membrane (Export and Assembly of Outer Membrane Proteins in E. coli). Although the emphasis of the book is on proteins, the role of phospholipids in controlling various cell surface processes is reviewed (Role of Phospholipids in coli Cell Function). I should point out the reason for the rapid progress in bacteria research is because of the possibility to apply biochemistry and genetics in this organism.

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Immunology has progressed in spectacular fashion in the last four decades. Studies of the response to infectious agents, transplanted organs and tumours (and the potential to manipulate that response), and the study of the immune system as a model system in molecular cell biology have yielded dramatic advances in our understanding of the mechanisms of immunity.The field has attracted a continuous stream of the brightest theoretical and experimental scientists for over forty years. This book conveys the philosophies and approaches of sixteen of the most successful of these scientists in the form of a series of narratives that describe the circumstances that led to a major discovery in immunology. Contributors not only recall an exciting period of research that helped shape modern immunology, but set it in the personal context of place and time. Jacques Miller, for example, describes the discovery of the function of the thymus, Rolf Zinkernagel explains how experiments on viral immunity led to the discovery of MHC restriction and Susumu Tonegawa provides an account of how antibody gene structure was defined. Medically-important discoveries include descriptions of early studies of autoimmunity by Noel Rose and of tumour immunology by George and Eva Klein.Far from being a collection of disinterested, historical accounts, this volume comprises a series of passionately biographical, personal essays that provide an unusually intimate insight into the scientific process. This book will be essential, and fascinating, reading for all those with an interest in immunology, and in the life sciences in general. For students and teachers, this will provide the background necessary for a true understanding of immunology, and to place subsequent discoveries in perspective. 246 pp. Englisch.

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Photobiology integrates a wide variety of scientific disciplines. As more people become aware of the many ways light interacts with chemical and biological systems, the need for a concise treatment of photobiology has become more critical. Kohen et al. Have written just such a book, intended both as a textbook and as a reference.The authors begin by providing a brief description of the nature of light, how it affects matter, and the means and methods of measuring it. A major section of the book is devoted to how light influences living systems, including discussions of photosynthesis, bioluminescence, regulatory mechanisms, and visual transduction of light. The last half of the book is devoted to the biomedical aspects of light, including photoimmunology, photoallergic reactions and other forms of light sensitivity, the optical properties of skin, and various ways that light can be used in therapy treatments.Useful to photobiologists as a comprehensive overview, this book should also appeal to biomedical researchers and advanced students of photobiology. 506 pp. Englisch.

Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -For this Handbook authors known to have different views regarding the nature of development economics have been selected. The Handbook is organised around the implications of different sets of assumptions and their associated research programs. It is divided into three volumes, each with three parts which focus on the broad processes of development.This third volume of the Handbook of Development Economics employs rigorous theoretical and empirical frameworks. It focuses on policy and includes material from unpublished and not generally available sources. In particular, it covers analytical and policy issues arising from the collapse of the paradigm of development based on import-substituting-industrialization in most developing countries; and the demise of centrally planned economies of Eastern Europe and the Soviet Union. The volume also deals with the increasing recognition of the importance of micro behavioral responses to a range of incentives and unobserved factors both for analysis and for policy formulation. It discusses the ongoing process of economic reforms in developing countries by reducing state involvement in the economy through privatization, opening up the economy much more to foreign trade and investment and allowing market forces and the private sector to guide resource allocation to a much greater extent. As well as updating developments on topics which were included in the earlier volumes, this Handbook also includes different topics, such as econometric and other empirical modeling tools for development analysis and the role of technology in the development process. As in the previous volumes of the series, the chapters in this Handbook provide self-contained surveys summarizing not only received knowledge but also recent developments. Each chapter is also a definitive source, reference and teaching supplement for use by researchers and advanced graduate students.For more detailed information on the Handbooks in Economics series, please see our home page on elsevier.nl/locate/hes 766 pp. Englisch.