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Librería: Lucky's Textbooks, Dallas, TX, Estados Unidos de America
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Idioma: Inglés
Publicado por Springer-Verlag Berlin and Heidelberg GmbH and Co. KG, DE, 1990
ISBN 10: 3540524584 ISBN 13: 9783540524588
Librería: Rarewaves.com USA, London, LONDO, Reino Unido
EUR 63,35
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Añadir al carritoPaperback. Condición: New. The first part of this book enables the reader to be familiarized with basic concepts of pharmacokinetics (Absorption, Distribution, Metabolism and Excretion - ADM E) following single dose administration. In this part these principles are applied to clinically relevant situations, namely, multiple or (sub) chronic administration. In day to day practice besides acute drug response, often a longer duration of action is desired. This situation needs the under standing of changes in pharmacokinetics of drugs upon repeated administra tion, and the dosage regimen has to be accordingly adjusted for achieving uniform therapeutic levels for desired period of time. 2 Multiple dosing The basic mathematical relationships applicable to single dose administration kinetics are also valid (with slight modifications) for multiple dose kinetics. In multiple dose therapy the ultimate purpose is to achieve a steady drug effect or response with minimum side effects. As mentioned before, this can be achieved in most cases by maintaining the plasma concentrations in therapeutic range for required number of hours or days. This may be considered as a general rule with an exception of nitrates, in which case the concentrations during the interval between two doses (called "dosing interval") should fall below a critical threshold level, such that tolerance does not develop. A drug is commonly administered in fixed doses at constant intervals of time so that the amount lost through elimination is replaced after each dose. Softcover reprint of the original 1st ed. 1990.
Librería: Ria Christie Collections, Uxbridge, Reino Unido
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Librería: GreatBookPricesUK, Woodford Green, Reino Unido
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Librería: GreatBookPricesUK, Woodford Green, Reino Unido
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Añadir al carritoPaperback. Condición: Brand New. 1st edition. 155 pages. 9.29x5.98x0.39 inches. In Stock.
Idioma: Inglés
Publicado por Springer Berlin Heidelberg, 1990
ISBN 10: 3540524584 ISBN 13: 9783540524588
Librería: moluna, Greven, Alemania
EUR 57,84
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Añadir al carritoCondición: New. The first part of this book enables the reader to be familiarized with basic concepts of pharmacokinetics (Absorption, Distribution, Metabolism and Excretion - ADM E) following single dose administration. In this part these principles are applied to clinica.
Idioma: Inglés
Publicado por Springer-Verlag Berlin and Heidelberg GmbH and Co. KG, DE, 1990
ISBN 10: 3540524584 ISBN 13: 9783540524588
Librería: Rarewaves.com UK, London, Reino Unido
EUR 59,25
Cantidad disponible: 1 disponibles
Añadir al carritoPaperback. Condición: New. The first part of this book enables the reader to be familiarized with basic concepts of pharmacokinetics (Absorption, Distribution, Metabolism and Excretion - ADM E) following single dose administration. In this part these principles are applied to clinically relevant situations, namely, multiple or (sub) chronic administration. In day to day practice besides acute drug response, often a longer duration of action is desired. This situation needs the under standing of changes in pharmacokinetics of drugs upon repeated administra tion, and the dosage regimen has to be accordingly adjusted for achieving uniform therapeutic levels for desired period of time. 2 Multiple dosing The basic mathematical relationships applicable to single dose administration kinetics are also valid (with slight modifications) for multiple dose kinetics. In multiple dose therapy the ultimate purpose is to achieve a steady drug effect or response with minimum side effects. As mentioned before, this can be achieved in most cases by maintaining the plasma concentrations in therapeutic range for required number of hours or days. This may be considered as a general rule with an exception of nitrates, in which case the concentrations during the interval between two doses (called "dosing interval") should fall below a critical threshold level, such that tolerance does not develop. A drug is commonly administered in fixed doses at constant intervals of time so that the amount lost through elimination is replaced after each dose. Softcover reprint of the original 1st ed. 1990.
Librería: Revaluation Books, Exeter, Reino Unido
EUR 59,81
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Añadir al carritoPaperback. Condición: Brand New. 1st edition. 155 pages. 9.29x5.98x0.39 inches. In Stock. This item is printed on demand.