Uber die Natur der Genmutation und der Genstruktur

N. W. Timofeeff-Ressovsky, K. G. Zimmer u. Max Delbruck

Editorial: Weidmannsch Buchhandlung, Berlin, 1935
Usado / PAMPHLET / Cantidad: 0
Librería: Robinson Street Books, IOBA (Binghamton, NY, Estados Unidos de America)
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First edition. Offprint. Presentation copy from N. W. Timofeeff-Ressovsky to L.C. Dunn. Dunn's ownership stamp present. Some splitting to spine. Spine label. A very good copy. Rare. Light math problem in ink back cover (Dunn?)."In 1935, Timofeev-Resovskij published the major work, Über die Natur der Genmutation und der Genstruktur, with Karl Zimmer, and Max Delbrück; it was considered to be a major advance in understanding the nature of gene mutation and gene structure.[24] The work was a keystone in the formation of molecular genetics." WikipediaThis is the famous "Green Pamphlet", "The Three Man Paper". Garrison and Morton 254.1 Molecular Biology. Provenance: William B. Provine * Quality, Value, Experience. Media Shipped in New Boxes. N° de ref. de la librería PRINT5DELBRUCK002

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Título: Uber die Natur der Genmutation und der ...
Editorial: Weidmannsch Buchhandlung, Berlin
Año de publicación: 1935
Encuadernación: PAMPHLET
Condición del libro: Very Good
Edición: 1st Edition

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Timoféeff-Ressovsky, N. W. (Nikolai Wladimirowitsch). Zimmer, K. G. (Karl Günter). Delbrück, M. (Max)
Editorial: Vandenhoeck & Ruprecht, Göttingen (1935)
Usado Tapa dura Cantidad: 1
Antiquariat Dr. Wolfgang Wanzke
(Gessertshausen, Alemania)

Descripción Vandenhoeck & Ruprecht, Göttingen, 1935. Halbleinen. Gr.-8vo. Halbleinen der Zeit mit Buntpapierbezug und handgeschriebenem Rückenschild, 2 Bll., 283, 2 Bll., 256 S. In: "Nachrichten von der Gesellschaft der Wissenschaften zu Göttingen, mathematisch-physikalische Klasse. Neue Folge. Fachgruppe VI, Nachrichten aus der Biologie, Band 1, Nr. 13, 1935, S. [189]-245. Sloan/Fogel: Creating a Physical Biology. The Three-Man Paper and early molecular biology. Univ. of Chikago Press, 2011. Jahn/Löther/Senglaub, Geschichte der Biologie, 740. - Das Gründungspapier der modernen Molekularbiologie, Bekannt als das "grüne Pamphlet", nach dem grünen Umschlag des Sonderdrucks, oder als das "Dreimännerwerk der Genetik", im Vergleich mit dem berühmten Pendant der Quantenmechanik (Born/Heisenberg/Jordan). Hier nicht der Sonderdruck, sondern die Originalpublikation im ersten Band der "Nachrichten aus der Biologie", mit Beiträgen aus den Jahren 1934/35, zusammen gebunden mit dem zweiten Band, der Arbeiten aus 1935/36 enthält. Im ersten Band zwei weitere Publikationen von Timoféeff-Ressovsky: 1. Über den Einfluß des genotypischen Milieus und der Außenbedingungen auf die Realisation des Genotyps. Genmutation vti (venae transversae imcompletae) bei Drosophila funebris (Nr. 6, S. [53]-106). 2. Auslösung von Vitalitätsmutationen durch Röntgenbestrahlung bei Drosophila melanogaster (Nr. 11, S. [163]-180). - The founding paper of modern molecular biology. Known as the "green paper" or the "three man paper" of genetics compared to the famous counterpart of quantum mechanics. Not the reprint but the origininal publication in "Nachrichten aus der Biologie", vol 1 and 2. - Einband in sehr gutem Zustand, Deckel minimal berieben. Ein Stempel und drei handschriftliche Signaturen auf dem Titel von Band 1. Ein weiterer Stempel am oberen Rand von S.1, Band 1. Ansonsten völlig sauber. / Binding in very good condition, covers insignificantly rubbed. One stamp and three handwritten shelfmarks on the title of vol. 1. Another stamp on the upper margin of page 1, vol. 1. Otherwise very clean. 1200 Gramm. Buch. Nº de ref. de la librería H-10-16934

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Timofeef, Zimmer, and Delbruck
Usado Tapa blanda Primera edición Cantidad: 1
Jeremy Norman's historyofscience
(Novato, CA, Estados Unidos de America)

Descripción 1935. Timofeeff-Ressovsky, Nikolai Vladimirovich (1900-1981), K. G. Zimmer and Max Delbruck (1906-81). Ueber die Natur der Genmutation und der Genstruktur. Offprint from Nachr. Ges. Wiss. Gottingen, math-fis. Kl., Fachgr. 6, 1 (1935). 8vo. [189]-245pp. Berlin: Weidmannsche Buchhandlung, 1935. 253 x 178 mm. Original green printed wrappers. Stamp on upper wrapper but fine and unopened. First Separate Edition. Garrison-Morton 254.1. One of the key conceptual papers in the early history of molecular biology. This paper represented the debut in genetics of the physicist Max Delbruck, a student and lifelong friend of Niels Bohr. Delbruck turned from quantum physics to biology after being inspired by Niels Bohr's speculations, in his 1935 lecture "Light and life," about the application of quantum mechanics to problems in biology. Delbruck won a share of the Nobel Prize for physiology or medicine in 1969 for his discoveries concerning the replication mechanism and the genetic structure of viruses. "Ueber die Natur der Genmutation und der Genstruktur" (often referred to as "the green paper" after the color of its wrappers, or the "Dreimanner" paper after the number of its authors) is divided into four sections. The first, by Timofeeff-Ressovsky, describes the mutagenic effects of x-rays and gamma rays on Drosophila melanogaster; the second part, by Zimmer, analyzes Timofeeff-Ressovsky's results theoretically. The third and most remarkable section, by Delbruck, puts forth a model of genetic mutation based on atomic physics that "shows the maturity, judgment and breadth of knowledge of someone who had been in the field for years . . . its carefully worded predictions have stood the test of time" (Perutz, p. 557). The three authors of the paper "concluded that a mutation is a molecular rearrangement within a particular molecule, and the gene a union of atoms with which a mutation, in the sense of a molecular rearrangement or dissociation of bonds, can occur. The actual calculations of the size of the gene, deduced from calculations on the assumption of a spherical target, were not cogent, as Delbruck wryly admitted in his Nobel Prize lecture, but the entire approach to the problem of mutation and the gene adopted by the three collaborators was highly stimulating to other investigators" (DSB [suppl.]). The Timofeeff-Zimmer-Delbruck paper provided much of the material for Erwin Schrodinger's book What is Life? (1944), a work that takes a "naive physicist's" approach to the problems of heredity and variation; it is often cited as having inspired Watson, Crick, Wilkins and others to focus their careers on the problems of molecular biology. The relationship between Schrodinger's book and the Timofeeff-Zimmer-Delbruck paper is examined in detail in Max Perutz's 1987 paper "Physics and the riddle of life," which points out, among other things, that the two most important chapters in Schrodinger's book were paraphrased from "Ueber die Natur der Genmutation und der Genstruktur." "In retrospect, the chief merit of What is Life? is its popularization of the Timofeeff, Zimmer and Delbruck paper that would otherwise have remained unknown outside the circles of geneticists and radiation biologists" (Perutz, p. 558). Perutz, "Physics and the riddle of life," Nature 326 (1987): 555-559. Nº de ref. de la librería 38569

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