Neuware -The present investigation is concerned with synthesis of new 2 and 6 - substituted 4H-chromen-4-One derivatives with the objectives of discovering novel and potent anti-inflammatory agents and anti-oxidants. The results of anti-inflammatory activity were revealed that the compound has indole 2 substitution with 4-nitrophenyl amino methyl (at 6th position) on 4H- chromen�4�one having more anti-inflammatory activity as compared to other substituent�s. While, indole 2 substituted 4-methoxy phenyl amino methyl (at 6th position) 4H�chromen�4�one showed outperformed anti-oxidant activity in different anti-oxidant model as compared to other substituent�s. The all newly synthesized compounds displayed moderate to potent anti-inflammatory and anti-oxidant activity and has therapeutic potential in combating this devastating inflammatory and oxidative condition of the body, might be deserve promising substances for further in vivo evaluation as anti-inflammatory and anti-oxidant properties. However the anti-inflammatory activity is not related to antioxidant potential.Books on Demand GmbH, �berseering 33, 22297 Hamburg 100 pp. Englisch.

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T�tulo

Synthesis & Evaluation of 2&6-Substituted 4H-Chromen-4-One Derivatives

Editor

LAP LAMBERT Academic Publishing Feb 2013

Fecha de publicaci�n

2013

Idioma

Ingl�s

ISBN 10

3659345490

ISBN 13

9783659345494

Encuadernaci�n

Taschenbuch

Estado

Neu

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Sinopsis

The present investigation is concerned with synthesis of new 2 and 6 - substituted 4H-chromen-4-One derivatives with the objectives of discovering novel and potent anti-inflammatory agents and anti-oxidants. The results of anti-inflammatory activity were revealed that the compound has indole 2 substitution with 4-nitrophenyl amino methyl (at 6th position) on 4H- chromen-4-one having more anti-inflammatory activity as compared to other substituent's. While, indole 2 substituted 4-methoxy phenyl amino methyl (at 6th position) 4H-chromen-4-one showed outperformed anti-oxidant activity in different anti-oxidant model as compared to other substituent's. The all newly synthesized compounds displayed moderate to potent anti-inflammatory and anti-oxidant activity and has therapeutic potential in combating this devastating inflammatory and oxidative condition of the body, might be deserve promising substances for further in vivo evaluation as anti-inflammatory and anti-oxidant properties. However the anti-inflammatory activity is not related to antioxidant potential.

Acerca del autor

Prof. Chirag J. Patel, Ph.D. fellow in Pharmaceutical Sciences at K.S.K.V. Kachchh University, Bhuj-Kachchh, Gujarat, INDIA. Field of Study: Phytopharmacoligal Screening of Some Laticiferous Plants & Drug Design with Development. Presently working as an Associate Professor at Veerayatan Institute of Pharmacy, India from last seven years.

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