From the Foreword..."[A] must read for all of us committed to understanding the interplay of structure and function...[T]he individual chapters outline the suite of major basic life science questions such as the status of efforts to predict protein structure and how proteins carry out cellular functions, and also the applied life science questions such as how structural bioinformatics can improve health care through accelerating drug discovery." This book provides a basic understanding of the theories, associated algorithms, resources, and tools used in structural bioinformatics. The reader emerges with the ability to make effective use of protein, DNA, RNA, carbohydrate, and complex structures to better understand biological function. Moreover, it draws a clear connection between structural studies and the rational design of new therapies.

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PHILIP E. BOURNE is a Professor in the Department of Pharmacology at the University of California San Diego and Director of Integrated Biosciences at the San Diego Supercomputer Center. He is also currently the President of the International Society for Computational Biology (ISCB). Dr. Bourne is the author of over 100 peer reviewed scientific papers and three previous books. HELGE WEISSIG is a Project Leader in Bioinformatics at ActivX Biosciences, a proteomics company, and also co-coordinates the Bioinformatics Certificate program for UCSD Extension. After doing his post-doctoral work with Prof. Bourne at the San Diego Supercomputer Center, he became the Technical Project Manager for the RCSB Protein Data Bank (PDB) at UCSD.

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