Single Neuron Studies of the Human Brain: Probing Cognition

Foundational studies of the activities of spiking neurons in the awake and behaving human brain and the insights they yield into cognitive and clinical phenomena.

In the last decade, the synergistic interaction of neurosurgeons, engineers, and neuroscientists, combined with new technologies, has enabled scientists to study the awake, behaving human brain directly. These developments allow cognitive processes to be characterized at unprecedented resolution: single neuron activity. Direct observation of the human brain has already led to major insights into such aspects of brain function as perception, language, sleep, learning, memory, action, imagery, volition, and consciousness. In this volume, experts document the successes, challenges, and opportunity in an emerging field.

The book presents methodological tutorials, with chapters on such topics as the surgical implantation of electrodes and data analysis techniques; describes novel insights into cognitive functions including memory, decision making, and visual imagery; and discusses insights into diseases such as epilepsy and movement disorders gained from examining single neuron activity. Finally, contributors consider future challenges, questions that are ripe for investigation, and exciting avenues for translational efforts.

Contributors
Ralph Adolphs, William S. Anderson, Arjun K. Bansal, Eric J. Behnke, Moran Cerf, Jonathan O. Dostrovsky, Emad N. Eskandar, Tony A. Fields, Itzhak Fried, Hagar Gelbard-Sagiv, C. Rory Goodwin, Clement Hamani, Chris Heller, Mojgan Hodaie, Matthew Howard III, William D. Hutchison, Matias Ison, Hiroto Kawasaki, Christof Koch, Rüdiger Köhling, Gabriel Kreiman, Michel Le Van Quyen, Frederick A. Lenz, Andres M. Lozano, Adam N. Mamelak, Clarissa Martinez-Rubio, Florian Mormann, Yuval Nir, George Ojemann, Shaun R. Patel, Sanjay Patra, Linda Philpott, Rodrigo Quian Quiroga, Ian Ross, Ueli Rutishauser, Andreas Schulze-Bonhage, Erin M. Schuman, Demetrio Sierra-Mercado, Richard J. Staba, Nanthia Suthana, William Sutherling, Travis S. Tierney, Giulio Tononi, Oana Tudusciuc, Charles L. Wilson

Itzhak Fried is Professor of Neurosurgery and Psychiatry and Biobehavioral Sciences in the David Geffen School of Medicine at UCLA and Professor of Neurosurgery at Tel-Aviv Medical Center and Tel Aviv University's Sackler Faculty of Medicine.

Ueli Rutishauser is Assistant Professor in the Department of Neurosurgery at Cedars-Sinai Medical Center in Los Angeles.

Moran Cerf is Professor of Neuroscience and Business at the Kellogg School of Management at Northwestern University and Northwestern's neuroscience program.

Gabriel Kreiman is Associate Professor of Ophthalmology and Neurology at Children's Hospital Boston, Harvard Medical School.

Itzhak Fried is Professor of Neurosurgery and Psychiatry and Biobehavioral Sciences in the David Geffen School of Medicine at UCLA and Professor of Neurosurgery at Tel-Aviv Medical Center and Tel Aviv University's Sackler Faculty of Medicine.

Ueli Rutishauser is Assistant Professor in the Department of Neurosurgery at Cedars-Sinai Medical Center in Los Angeles.

Moran Cerf is Professor of Neuroscience and Business at the Kellogg School of Management at Northwestern University and Northwestern's neuroscience program.

Gabriel Kreiman is Associate Professor of Ophthalmology and Neurology at Children's Hospital Boston, Harvard Medical School.

Itzhak Fried is Professor of Neurosurgery and Psychiatry and Biobehavioral Sciences in the David Geffen School of Medicine at UCLA and Professor of Neurosurgery at Tel-Aviv Medical Center and Tel Aviv University's Sackler Faculty of Medicine.

Itzhak Fried is Professor of Neurosurgery and Psychiatry and Biobehavioral Sciences in the David Geffen School of Medicine at UCLA and Professor of Neurosurgery at Tel-Aviv Medical Center and Tel Aviv University's Sackler Faculty of Medicine.

Ueli Rutishauser is Assistant Professor in the Department of Neurosurgery at Cedars-Sinai Medical Center in Los Angeles.

Moran Cerf is Professor of Neuroscience and Business at the Kellogg School of Management at Northwestern University and Northwestern's neuroscience program.

Gabriel Kreiman is Associate Professor of Ophthalmology and Neurology at Children's Hospital Boston, Harvard Medical School.

Ueli Rutishauser is Assistant Professor in the Department of Neurosurgery at Cedars-Sinai Medical Center in Los Angeles.

Rodrigo Quian Quiroga, a native of Argentina, is Professor and Director of the Bioengineering Research Centre at the University of Leicester.

Christof Koch is President and Chief Scientist of the Allen Institute for Brain Science in Seattle, following twenty-seven years as a Professor at the California Institute of Technology. He is the author of Consciousness: Confessions of a Romantic Reductionist (MIT Press), The Quest for Consciousness: A Neurobiological Approach, and other books.

Itzhak Fried is Professor of Neurosurgery and Psychiatry and Biobehavioral Sciences in the David Geffen School of Medicine at UCLA and Professor of Neurosurgery at Tel-Aviv Medical Center and Tel Aviv University's Sackler Faculty of Medicine.

Gabriel Kreiman is Associate Professor of Ophthalmology and Neurology at Children's Hospital Boston, Harvard Medical School.

Itzhak Fried is Professor of Neurosurgery and Psychiatry and Biobehavioral Sciences in the David Geffen School of Medicine at UCLA and Professor of Neurosurgery at Tel-Aviv Medical Center and Tel Aviv University's Sackler Faculty of Medicine.

Moran Cerf is Professor of Neuroscience and Business at the Kellogg School of Management at Northwestern University and Northwestern's neuroscience program.

Itzhak Fried is Professor of Neurosurgery and Psychiatry and Biobehavioral Sciences in the David Geffen School of Medicine at UCLA and Professor of Neurosurgery at Tel-Aviv Medical Center and Tel Aviv University's Sackler Faculty of Medicine.

Ueli Rutishauser is Assistant Professor in the Department of Neurosurgery at Cedars-Sinai Medical Center in Los Angeles.

Ueli Rutishauser is Assistant Professor in the Department of Neurosurgery at Cedars-Sinai Medical Center in Los Angeles.

Itzhak Fried is Professor of Neurosurgery and Psychiatry and Biobehavioral Sciences in the David Geffen School of Medicine at UCLA and Professor of Neurosurgery at Tel-Aviv Medical Center and Tel Aviv University's Sackler Faculty of Medicine.

Moran Cerf is Professor of Neuroscience and Business at the Kellogg School of Management at Northwestern University and Northwestern's neuroscience program.

Gabriel Kreiman is Associate Professor of Ophthalmology and Neurology at Children's Hospital Boston, Harvard Medical School.