Selective and Specific If Inhibition in Cardiovascular Disease

Idioma: inglés

Editorial: Lippincott Williams & Wilkins, London, 2003

0781746809 / 9780781746809

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Scarce hardcover, x + 134 pages, glossy paper, index, NOT ex-library. Interior in very good condition: clean, bright, untanned, with unmarked text and tight binding, free of readily noticeable creasing. Boards gently shelfworn showing short creases/bumps to edges and wrinkles to spine ends, faint marks and scratches, limited scuffing. Published without a dust jacket. --- The data presented and discussed in this monograph support the concept of heart rate reduction as a valuable therapeutic option for reducing morbidity and mortality in a wide range of cardiovascular disease. Clinical evidence has been accumulating for many years to suggest a link between heart rate and mortality in patients with coronary artery disease, as well as in the general population. Epidemiologic data, particularly from the Framingham study, have also indicated a strong link between sudden cardiac death and sustained elevated heart rate, raising the issue that slow heart rate per se might exert an antifibrillatory action. In this respect, an elevated heart rate can be considered as an independent risk factor for cardiovascular mortality. There is also evidence to suggest that a sustained elevated heart rate may play a direct role in the pathogenesis of coronary atherosclerosis. It is widely accepted that lowering heart rate can reduce the risk of cardiovascular events and increase life expectancy.The heart rate-lowering effects of beta blockers have been correlated with reduced cardiovascular and total mortality in post-myocardial infarction and heart failure patients. In theory, a highly specific heart rate-lowering agent should have the same beneficial effects with respect to reduced risk and mortality and may avoid some of the drawbacks associated with beta blocker therapy. The objectives of current therapies are to increase coronary blood flow and decrease myocardial oxygen demand. Heart rate is a critical determinant of myocardial oxygen consumption and a reduction in heart rate usually leads to a reduction in myocardial oxygen consumption. Coronary blood flow can be improved by a slower heart rate due to an increase in diastolic perfusion time during the heart cycle. The role of specific heart rate-lowering agents needs to be explored in this context.

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Detalles bibliográficos

Título
Selective and Specific If Inhibition in Cardiovascular Disease
Autor
Bramah N. Singh; Paul M. Vanhoutte
Editorial
Lippincott Williams & Wilkins, London
Año de publicación
2003
Estado
Very Good
Encuadernación
Hardcover
Idioma
inglés
ISBN 10
0781746809
ISBN 13
9780781746809

killarneybooks

Inagh, Clare, Irlanda

Vendedor de 5 estrellas

Vendedor de AbeBooks desde 20 de abril de 2017

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All U.S.-bound orders are now shipped with UPS for reliable delivery. Additional customs or import fees are highly unlikely; however, please note buyers remain responsible for any duties or taxes that U.S. Customs may assess. -- Killarneybooks is a family-run bookshop based in the Republic of Ireland. We take pride in accurate listings, careful packaging, and prompt service - most orders ship within 24 hours. All books listed are in stock and ready for immediate dispatch - we are not dropshippers. Inquiries always welcome.

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