Mesoionic compounds are synthetic substances that belong to the class of heterocyclic betaines. Among this class, the sidnones stand out. The sydnones were first prepared by Earl and Mackney at the University of Sydney in 1935 and this gave rise to their name: sydnone. They have structures, chemical properties, synthetic utility and biological activities that are considered relevant. One of these characteristics is their possible anti-cancer effect. Cancer is one of the main causes of death and every year more people are affected by the disease. Current treatments have low efficacy and many side effects, which is why there is a great desire for new, more effective drugs to treat this disease. For this reason, the aim of this work was to provide a narrative review to analyze the potential of siddnones for future use in cancer therapy, as well as detailing their chemical and unique properties.

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