Paperback. Antibiotics have vastly changed the way we fight diseases. History is replete with examples of infectious diseases that have killed millions of people worldwide in the past and continues to do so in the present. However, there is one major difference. In the past there were novel classes of antibiotics that were being discovered at regular intervals, and in the present we are running out of options. Moreover, whatever antibiotics we have, microbes have developed resistance, which could primarily be attributed to the injudicious usage of antibiotics, not only for humans but also for veterinary purposes. A previous report from World Health Organization (WHO, 2017) suggests that antimicrobial resistance is a serious hazard and antibiotics under clinical development may not be sufficient (or efficient enough) to treat these emerging resistant pathogens. That report had identified 51 antibiotics and 11 biologicals. Of those, only 12 were found to be active against WHO classified critical priority pathogens and only two of them were found to be active against more than one specific pathogen. Starting with the sulphonamides in the 1930s to lipopeptides in the early 2000s, research and development on novel antibiotics is usually a slow and painful process and currently it will suffice to say that it is on the decline. As per the Infectious Diseases Society of America (IDSA), we are facing what is known as an antibiotic paradox that is pushing against the development of novel antibiotics. Interestingly, though there are studies that keep reporting on antibiotics, most of these are on combinatorial use of antibiotics. What could be their effectiveness and more importantly what could be their biotoxicity in the long run, remains unknown. Microbial antibiotic resistance is not a new phenomenon and there are numerous studies that have demonstrated the various mechanisms underlying it. An interesting study by Indian Council of Medical Research (ICMR), has shown that commensals in the gastrointestinal tract of humans might be responsible for the increasing ineffectiveness of antibiotics, at least in Indians. This makes it clear that microbes will keep on producing resistance to antibiotics at a faster rate compared to our ability to develop them. Under these circumstances, natural compounds, primarily plant-based, have become valuable tools and could be our answer to not only effective antimicrobial principles, but also to antimicrobial resistance. These compounds are abundant in nature and there is already a very rich literature on their usage and efficacy based on the various traditional systems of medicine. These natural compounds have been shown to be effective against both Gram positive and Gram-negative pathogens and interestingly microbes have a limited chance (as far as studies show) of developing resistance towards them. This is primarily attributed to the fact that most of these compounds are used as polyherbal formulations. Another advantage in studying these natural compounds is that there is a better probability of hitting upon that jackpot molecule or molecules for antimicrobial applications. Being relatively safe and inexpensive makes them very attractive areas for clinical research. This book, in line with others in the field, is a small attempt to highlight the developments related to the antimicrobial compounds from natural sources and their mechanisms of action, particularly against ESKAPE pathogens. This book, we believe, will serve as a small but important piece of source material for students and researchers interested in this particular area of research. The chapters are divided to showcase the relevance and importance of natural compounds as novel antimicrobials, inhibitors of antimicrobial resistance and immunomodulators and we hope that the topics will kindle the interest of young researchers in these lines. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

N� de ref. del art�culo 9781536185034

Contactar al vendedor

Denunciar este art�culo

Detalles bibliogr�ficos

T�tulo: Recent Trends in Understanding and Tackling Gram-Negative Infections (Paperback)
Editor: Nova Science Publishers Inc, New York
Fecha de publicaci�n: 2020
Idioma: Ingl�s
ISBN 10: 1536185035
ISBN 13: 9781536185034
Encuadernaci�n: Paperback
Estado: new

Acerca de

Sinopsis

Antibiotics have vastly changed the way we fight diseases. History is replete with examples of infectious diseases that have killed millions of people worldwide in the past and continues to do so in the present. However, there is one major difference. In the past there were novel classes of antibiotics that were being discovered at regular intervals, and in the present we are running out of options. Moreover, whatever antibiotics we have, microbes have developed resistance, which could primarily be attributed to the injudicious usage of antibiotics, not only for humans but also for veterinary purposes. A previous report from World Health Organization (WHO, 2017) suggests that antimicrobial resistance is a serious hazard and antibiotics under clinical development may not be sufficient (or efficient enough) to treat these emerging resistant pathogens. That report had identified 51 antibiotics and 11 biologicals. Of those, only 12 were found to be active against WHO classified critical priority pathogens and only two of them were found to be active against more than one specific pathogen. Starting with the sulphonamides in the 1930s to lipopeptides in the early 2000s, research and development on novel antibiotics is usually a slow and painful process and currently it will suffice to say that it is on the decline. As per the Infectious Diseases Society of America (IDSA), we are facing what is known as an antibiotic paradox that is pushing against the development of novel antibiotics. Interestingly, though there are studies that keep reporting on antibiotics, most of these are on combinatorial use of antibiotics. What could be their effectiveness and more importantly what could be their biotoxicity in the long run, remains unknown. Microbial antibiotic resistance is not a new phenomenon and there are numerous studies that have demonstrated the various mechanisms underlying it. An interesting study by Indian Council of Medical Research (ICMR), has shown that commensals in the gastrointestinal tract of humans might be responsible for the increasing ineffectiveness of antibiotics, at least in Indians. This makes it clear that microbes will keep on producing resistance to antibiotics at a faster rate compared to our ability to develop them. Under these circumstances, natural compounds, primarily plant-based, have become valuable tools and could be our answer to not only effective antimicrobial principles, but also to antimicrobial resistance. These compounds are abundant in nature and there is already a very rich literature on their usage and efficacy based on the various traditional systems of medicine. These natural compounds have been shown to be effective against both Gram positive and Gram-negative pathogens and interestingly microbes have a limited chance (as far as studies show) of developing resistance towards them. This is primarily attributed to the fact that most of these compounds are used as polyherbal formulations. Another advantage in studying these natural compounds is that there is a better probability of hitting upon that jackpot molecule or molecules for antimicrobial applications. Being relatively safe and inexpensive makes them very attractive areas for clinical research. This book, in line with others in the field, is a small attempt to highlight the developments related to the antimicrobial compounds from natural sources and their mechanisms of action, particularly against ESKAPE pathogens. This book, we believe, will serve as a small but important piece of source material for students and researchers interested in this particular area of research. The chapters are divided to showcase the relevance and importance of natural compounds as novel antimicrobials, inhibitors of antimicrobial resistance and immunomodulators and we hope that the topics will kindle the interest of young researchers in these lines. In the end, we are grateful and whole heartedly acknowledge the authors for their valuable contribution and reviewers for their valuable suggestions and critical review of the manuscripts.

Acerca del autor

Charlotte y Peter Fiell son dos autoridades en historia, teor�a y cr�tica del dise�o y han escrito m�s de sesenta libros sobre la materia, muchos de los cuales se han convertido en �xitos de ventas. Tambi�n han impartido conferencias y cursos como profesores invitados, han comisariado exposiciones y asesorado a fabricantes, museos, salas de subastas y grandes coleccionistas privados de todo el mundo. Los Fiell han escrito numerosos libros para TASCHEN, entre los que se incluyen 1000 Chairs, Dise�o del siglo XX, El dise�o industrial de la A a la Z, Scandinavian Design y Dise�o del siglo XXI.

"Sobre este t�tulo" puede pertenecer a otra edici�n de este libro.

Descripci�n de la librer�a

Ver la p�gina web de la librer�a

Informaci�n empresarial del vendedor

APOLLO ONLINE CORP.
605 Geddes Street, Wilmington, DE, 19805, U.S.A.

Condiciones de venta y env�o

Condiciones de venta

We guarantee the condition of every book as it�s described on the Abebooks web sites. If you�ve changed
your mind about a book that you�ve ordered, please use the Ask bookseller a question link to contact us
and we�ll respond within 2 business days.
Books ship from California and Michigan.

Derecho a cancelaci�n

Si eres un consumidor puedes cancelar el presente contrato de acuerdo con lo indicado a continuaci�n. Son consumidores las personas f�sicas que act�en con un prop�sito ajeno a su actividad comercial, empresarial, oficio o profesi�n.

Documento de informaci�n al consumidor y usuario sobre el desistimiento

Derecho de desistimiento:

Tienes derecho a desistir del presente contrato en un plazo de 14 d�as naturales sin necesidad de justificaci�n.

El plazo de desistimiento expirar� a los 14 d�as naturales del d�a en que t� o un tercero que hayas indicado, distinto del transportista, adquiera la posesi�n material del �ltimo bien, componente o pieza.

Para ejercer el derecho de desistimiento, deber�s notificarnos a Grand Eagle Retail, 26C Trolley Square, 19806, Wilmington, Delaware, U.S.A., 1 (302) 261-2674, de tu decisi�n de desistir del contrato a trav�s de una declaraci�n inequ�voca (por ejemplo, una carta enviada por correo postal, fax o correo electr�nico). Podr�s utilizar el modelo de formulario de desistimiento que figura a continuaci�n, aunque su uso no es obligatorio. Tienes asimismo la opci�n de cumplimentar y enviar electr�nicamente el modelo de formulario de desistimiento o cualquier otra declaraci�n inequ�voca a trav�s de nuestro sitio web a "Mis pedidos" en "Mi cuenta". Si recurres a esta opci�n, te comunicaremos sin demora en un soporte duradero (por ejemplo, por correo electr�nico) la recepci�n de dicho desistimiento.

Para cumplir el plazo de desistimiento, basta con que la comunicaci�n relativa al ejercicio por tu parte de este derecho sea enviada antes de que venza el plazo correspondiente.

Consecuencias del desistimiento:

En caso de desistimiento por tu parte, te devolveremos todos los pagos recibidos de ti, incluidos los gastos de entrega (con la excepci�n de los gastos adicionales resultantes de la elecci�n por tu parte de una modalidad de entrega diferente a la modalidad menos costosa de entrega ordinaria que ofrezcamos) sin ninguna demora indebida y, en todo caso, a m�s tardar 14 d�as naturales a partir de la fecha en la que se nos informes de tu decisi�n de desistir del presente contrato. Procederemos a efectuar dicho reembolso utilizando el mismo medio de pago empleado por ti para la transacci�n inicial, a no ser que hayas dispuesto expresamente lo contrario; en todo caso, no incurrir�s en ning�n gasto como consecuencia del reembolso.

Podremos retenerte el reembolso hasta haber recibido los bienes, o hasta que hayas presentado una prueba de la devoluci�n de los mismos, seg�n qu� condici�n se cumpla primero. Deber�s devolvernos o entregarnos directamente los bienes a Grand Eagle Retail, Grand Eagle Retail c/o Kable Product Services, 4275 Thunderbird Lane, 45014-45, Fairfield, Ohio, U.S.A., 1 (302) 261-2674, sin ninguna demora indebida y, en cualquier caso, a m�s tardar en el plazo de 14 d�as naturales a partir de la fecha en que nos comuniques tu decisi�n de desistimiento del contrato. Se considerar� cumplido el plazo si efect�as la devoluci�n de los bienes antes de que haya concluido dicho plazo. Deber�s asumir el coste directo de devoluci�n de los bienes. Solo ser�s responsable de la disminuci�n de valor de los bienes resultante de una manipulaci�n distinta a la necesaria para establecer la naturaleza, las caracter�sticas y el funcionamiento de los bienes.

Excepciones al derecho de desistimiento:

La entrega de peri�dicos, publicaciones especializadas o revistas con la excepci�n de contratos de suscripci�n; y
La entrega de contenido digital (incluyendo apps, software digital e-books, MP3, etc.) que no hubiera sido entregado en un medio tangible (por ejemplo: CD o DVD), si al realizar tu pedido has aceptado que podemos proceder al env�o del producto y que no resulta posible su cancelaci�n una vez comienza la entrega.

Modelo de formulario de desistimiento

(S�lo debe cumplimentar y enviar el presente formulario si desea desistir del contrato)

A la atenci�n de: (Grand Eagle Retail, 26C Trolley Square, 19806, Wilmington, Delaware, U.S.A., 1 (302) 261-2674)

Por la presente le comunico/comunicamos* que desisto de mi/desistimos de nuestro* contrato de venta del siguiente bien/prestaci�n del siguiente servicio*

Pedido el/recibido el*:

Nombre del consumidor y usuario o de los consumidores y usuarios:

Domicilio del consumidor y usuario o de los consumidores y usuarios:

Firma del consumidor y usuario o de los consumidores y usuarios (solo si el presente formulario se presenta en papel):

Fecha:

* Eliminar en su caso

Condiciones de env�o

Orders usually ship within 2 business days. All books within the US ship free of charge. Delivery is 4-14 business days anywhere in the United States.

Books ship from California and Michigan.

If your book order is heavy or oversized, we may contact you to let you know extra shipping is required.

Tarifas de env�o en Estados Unidos de America

Tarifas de env�o en Estados Unidos de America
Cantidad del pedido	De 6 a 16 d�as h�biles	De 6 a 14 d�as h�biles
Primer art�culo	EUR 0.00	EUR 0.00

Los plazos de entrega los establecen los vendedores y var�an seg�n el transportista y la ubicaci�n. Los pedidos que pasan por la aduana pueden sufrir retrasos y los compradores son responsables de los aranceles o tarifas asociadas. Los vendedores pueden ponerse en contacto con usted en relaci�n con cargos adicionales para cubrir cualquier aumento en los costes de env�o de los art�culos.