Recent Breakthroughs in Neurodegenerative Disorders and Enzyme Therapy

Neurodegenerative disorders pose a significant global health challenge, affecting millions of individuals and placing immense strain on families, healthcare systems, and economies. Advancements in understanding the underlying molecular mechanisms have opened new avenues for early diagnosis and targeted therapies. Innovative treatments like enzyme replacement and gene-editing technologies offer promising potential to slow disease progression and improve quality of life. These scientific breakthroughs not only enhance clinical care but also catalyze interdisciplinary collaboration across research, medicine, and policy. As society confronts aging populations and increasing neurological conditions, continued innovation in this field is crucial for sustainable, compassionate healthcare solutions. Recent Breakthroughs in Neurodegenerative Disorders and Enzyme Therapy explores molecular mechanisms, diagnostic, strategies, and therapeutic advancements for neurodegenerative conditions. Designed to bridge basic science and clinical applications, this book examines the role of lysosomal enzymes, advancements in gene-editing for enzyme delivery, and the translation of lab findings into real-world therapies. Covering topics such as artificial intelligence, neuroimaging, and radiation, this book is an excellent resource for neuroscientists, clinicians, medical researchers, biochemists, and more.

Dr. Prashant Tiwari , Ph.D., is an Associate Professor in the Department of Pharmacology at the College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, India. He holds a Ph.D. from Siksha O Anusandhan University, Bhubaneswar, and was a fellow of the Indian Council of Medical Research (ICMR), New Delhi. With over 13 years of experience in teaching and research, Dr. Tiwari’s expertise includes drug screening, method validation for brain-targeted drug delivery, drug-induced dyskinesia revalidation, and the neuroprotective effects of benzimidazole derivatives. His research has explored the dopaminergic pathway, prolactin inhibition, and neuroprotection, with notable studies on Nanoemulsions containing Lepidium sativum oil for Parkinson’s disease and Muntingia Calabura leaf extract for Alzheimer’s disease. For his outstanding work, Dr. Tiwari received the Dr. P. D. Patil National Award for Best Thesis in Pharmaceutical Sciences (2022). In addition to his research, Dr. Tiwari has authored 5 books, edited 5 books, and co-authored 6 book chapters. He has filed 7 patents, 2 of which have been granted. He organized a national e-seminar on targeted drug delivery against neurodegenerative diseases, sponsored by the Department of Biotechnology (DBT), Government of India. Dr. Tiwari has been honored with various awards, including the ICMR Senior Research Fellowship, Young Scientist Award, and Best Teacher Award. He supervises 5 Ph.D. students and has guided 9 M. Pharm students. He is also an active member of professional bodies and serves as a peer reviewer for international journals. His research interests span neurodegenerative disorders, drug interactions, pharmacokinetics/pharmacodynamics, and metabolic disorders.

Dr. Sunil Kumar Kadiri is an accomplished pharmaceutical sciences academician and researcher, presently serving as an Associate Professor at the College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru. With over 17 years of combined teaching and research experience, 5 years as Assistant Professor and 12 years as Associate Professor, his career spans notable institutions across Hyderabad and Bengaluru. Dr. Kadiri holds a Ph.D. in Pharmaceutical Sciences from JNTU Hyderabad (2019), an M.Pharm in Pharmacology with distinction (2008), and a B.Pharm from RGUHS, Bangalore. His academic interests encompass teaching, pharmaceutical research, pre-clinical and clinical studies. He has made extensive contributions to the field through over 75 peer-reviewed publications, several of which are indexed in Scopus and Web of Science, SCIE. His research includes drug-drug interactions, neuropharmacology, phytopharmacology, and herbal formulations. Dr. Kadiri has authored and co-authored numerous book chapters and textbooks and has been granted patents in India and the UK. He has actively participated in national and international seminars, delivered webinars, and served as a lead speaker on psychopharmacology and public health topics. His scientific curiosity and commitment to academic excellence continue to drive innovation in drug development, pharmacological screening, and therapeutic strategies.

Neha Minocha An academic professional with more than 10 years of experience, Dr. Neha Minocha working as an Associate Professor in Pharmaceutics at School of Medical and Allied Sciences, K. R. Mangalam University, Haryana. Dr. Neha has done her Ph.D. in Pharmaceutical Sciences in 2023. She has a background of Pharmaceutics in M. Pharmacy (2013) and have worked with many renowned universities. Dr. Neha has done her B. Pharmacy in 2011 and have two post graduate diplomas one in Post Graduate Diploma in Regulatory Affairs (PGDRA) from Jamia Hamdard, New Delhi and other one is Post Graduate Diploma in Clinical Research (PGDCR) from Apheta Institute, New Delhi. Dr. Neha have published 33 peer reviewed publications in SCOPUS, WoS indexed journals and have four book chapters with renowned publishers. She has published 1 patent and 6 patents have been granted under her name.