T�tulo: QSAR Based Design & Synthesis: Design, Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives
Editor: LAP LAMBERT Academic Publishing
Fecha de publicaci�n: 2012
Idioma: Ingl�s
ISBN 10: 3846586021
ISBN 13: 9783846586020
Encuadernaci�n: Paperback
Estado: Like New
Tipo de libro: book

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We carried out a QSAR study on benzotriazine derivatives & studied 28 potent GABAA receptor ligands; derivatives of benzotriazines, using a combination of various physicochemical, steric, electronic and thermodynamic descriptors to determine the quantitative correlation between binding affinity and structural features with potent anticonvulsant activity. Correlation between these properties and anticonvulsant activity was used to synthesize compounds possessing potent anticonvulsant activity. Most of the compounds showed an ability to inhibit the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions. Compound 1A, i.e. 2-(4-Chloro-phenyl)-5-nitro-1H-benzimidazole exhibited maximum activity.

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