Protein Instability at Interfaces During Drug Product Development : Fundamental Understanding, Evaluation, and Mitigation
Idioma: inglés
Editorial: Springer, 2021
Serie: Libro 38 de 38 - AAPS Advances in the Pharmaceutical Sciences
- Tapa dura
- Nuevo
Librería: GreatBookPrices, Columbia, MD, Estados Unidos de AmericaGreatBookPrices
Vendedor de IberLibro desde 6 de abril de 2009
Condición: Nuevo
EUR 180,01
Cantidad disponible: 15 disponibles
Añadir al carritoN° de ref. del artículo 43272417-n
- Título
- Protein Instability at Interfaces During Drug Product Development : Fundamental Understanding, Evaluation, and Mitigation
- Autor
- Li, Jinjiang (EDT); Krause, Mary E. (EDT); Tu, Raymond (EDT)
- Editorial
- Springer
- Año de publicación
- 2021
- Estado
- New
- Encuadernación
- Encuadernación de tapa dura
- Idioma
- inglés
- ISBN 10
- 3030571769
- ISBN 13
- 9783030571764
- Serie
- Libro 38 de 38: AAPS Advances in the Pharmaceutical Sciences
Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.
“Sinopsis” puede pertenecer a otra edición de este título.
Acerca del autor
Dr. Jinjiang Li obtained his M.S. in surface chemistry from the University of Western Ontario, London, Ontario and his Ph.D. in physical chemistry of biomaterials from McGill University, Montreal, Canada, followed by postdoctoral training in pharmaceutics at the School of Pharmacy, University of Wisconsin at Madison. Dr. Li is an expert on drug product development with extensive industrial experience and many publications. He has worked with many major pharmaceutical companies including Boehringer-Ingelheim and Bristol Myers Squibb, involved in the product development of many therapeutic areas. Dr. Li published about 50 articles in a variety of topics, from polymer science and colloids to pharmaceutical drug product development. Currently, his interest centers on the impact of interfacial stress on the development of biologics with focus on the development of drug-device combination product. He is the current chairman of AAPS Protein Purification, Storage, Transportation and Drug-Device Combination community.
Dr. Mary E. Krause works in the Drug Product Development Department of Bristol Myers Squibb in New Brunswick, NJ. She received her M.S. in chemistry from Missouri State University, and her Ph.D. in chemistry from the University of Kansas, with subsequent post-doctoral training in pharmaceutical chemistry at the University of Kansas as a PhRMA Foundation Post-Doctoral Fellow. Her work focused on the characterization of a novel metal binding peptide tag and resulting metal complexes, including novel platinum protein conjugates for use as targeted anti-cancer therapeutics. Dr. Krause’s current research interests include formulation and process development of biologic drug products, with emphasis on antibody drug conjugates, metal-catalyzed oxidation, and the effects of process and interfacial stress on long-term stability. She is lead author/co-inventor on multiple publications, patents, conference presentations, and invited lectures.
Professor Raymond Tu is a Chemical Engineering faculty member in the Grove School of Engineering at The City College of New York – CUNY. Dr. Tu received his PhD in chemical engineering from the University of California - Santa Barbara in 2004, studying the design and self-assembly of peptide functionalized molecular architectures. Subsequently, he completed a post-doctoral fellowship in 2005 at Georgia Institute of Technology investigating rheological properties of biologically functionalized polymer-based materials. The current focus of his research program is the synthesis and characterization of surface-active molecular building blocks. The approach his group uses couples classical interfacial tools to examine dynamics with simple transport models to understand the fundamentals of adsorption. This methodology is proving to be an effective tool for understanding biologic drug product development and engineering complex composite materials.
“Acerca de” puede pertenecer a otra edición de este título.
GreatBookPrices
Columbia, MD, Estados Unidos de America
Vendedor de IberLibro desde 6 de abril de 2009
Tarifas de envío en Estados Unidos de America
| Artículo | De 5 a 14 días hábiles | De 8 a 14 días hábiles |
|---|---|---|
| Primer artículo | EUR 2,35 | EUR 2,35 |
Métodos de pago
Descripción de la tienda
SuperBookDeals.com is your top source for finding new books at the absolute lowest prices, guaranteed ! We offer big discounts - everyday - on millions of titles in virtually any category, from Architecture to Zoology -- and everything in between. Discover great deals and super-savings, on professional books, text book titles, the newest computer guides, or your favorite fiction authors. You'll find it all - at HUGE SAVINGS - at SuperBookDeals. Browse through our complete online product catalog today. Serving customers around the world for years, we help thousands find just the books they're looking for -- at incredibly low, bargain prices.…
Información empresarial del vendedor
Expert Trading Limited
9220 Rumsey Road, Suite 101
Columbia, MD Estados Unidos de America 21045
Condiciones de venta
Company Name: GreatBookPrices
Legal Entity: Expert Trading, LLC
Address: 6310 Stevens Forest, suite 200, Columbia MD 21046
Email address: CustomerService@SuperBookDeals.com
Phone number: 410-964-0026
consumer complaints can be addressed to address above
Registration #: 52-1713923
Authorized representative: Danielle Hainsey
Derecho al desistimiento
Si es un consumidor, puede rescindir el contrato de acuerdo con lo siguiente. Por consumidor se entiende cualquier persona física que actúe con fines ajenos a su actividad comercial, empresarial, oficio o profesión.
Información sobre el derecho de desistimiento
Derecho legal de desistimiento
Tiene derecho a rescindir este contrato en un plazo de 14 días sin dar ningún motivo.
El periodo de desistimiento vencerá a los 14 días desde que usted, o un tercero que no sea el transportista e indicado por usted, adquiera la posesión física del último bien o del último lote o pieza.
Para ejercer el derecho de desistimiento, complete de forma electrónica y envíe una declaración clara en nuestro sitio web, desde "Mis compras" en "Mi cuenta". Le enviaremos sin demora un acuse de recibo de dicho desistimiento a través de un soporte duradero (por ejemplo, por correo electrónico).
Para cumplir con el plazo de desistimiento, basta con que envíe su comunicación relativa al ejercicio del derecho de desistimiento antes de que venza el periodo de desistimiento.
Efectos del desistimiento
Si rescinde este contrato, le reembolsaremos todos los pagos que hayamos recibido de usted, incluidos los gastos de envío (excepto los gastos adicionales que surjan si elige un tipo de envío que no sea el tipo de envío estándar más económico que ofrecemos).
Podemos hacer una deducción del reembolso por la pérdida de valor de cualquier bien suministrado, si la pérdida es el resultado de una manipulación innecesaria por su parte.
Efectuaremos el reembolso sin demoras indebidas y, a más tardar, 14 días después de que se nos informe de su decisión de rescindir este contrato.
Efectuaremos el reembolso utilizando el mismo medio de pago que utilizó para la transacción inicial, a menos que haya acordado expresamente lo contrario; en cualquier caso, no incurrirá en ningún cargo como resultado de dicho reembolso.
Podremos retener el reembolso hasta que hayamos recibido los bienes o hasta que nos haya presentado una prueba de que los ha devuelto, lo que ocurra primero.
Deberá devolver los bienes o entregarlos a GreatBookPrices, Bensenville, Illinois, U.S.A., sin demoras indebidas y, en cualquier caso, en un plazo máximo de 14 días a partir del día en que nos comunique su desistimiento del presente contrato. El plazo se cumple si devuelve la mercancía antes de que venza el periodo de 14 días. Tendrá que asumir los gastos directos de devolución de los bienes. Usted solo es responsable de la disminución del valor de los bienes como resultado de una manipulación distinta a la necesaria para establecer la naturaleza, las características y el funcionamiento de los bienes.
Excepciones al derecho de desistimiento
El derecho de desistimiento no se aplica a lo siguiente:
- La entrega de periódicos, diarios o revistas, con la excepción de los contratos de suscripción; y
- El suministro de contenido digital que no se proporcione en un soporte tangible (por ejemplo, en un CD o DVD) si, al hacer el pedido, aceptó que podíamos empezar a entregarlo y que no podría desistir una vez iniciada la entrega.
Condiciones de envío
Our warehouses across the globe are fully operational without substantial delays. We are working hard and continue to overcome the daily challenges presented by COVID-19. We appreciate your understanding.
Internal processing of your order will take about 1-2 business days. Please allow an additional 4-14 business days for Media Mail delivery. We have multiple ship-from locations - MD,IL,NJ,UK,IN,NV,TN & GA