Prostate Cancer: Advancements in the Pathogenesis, Diagnosis and Personalized Therapy

This book provides an in-depth exploration of the biology of prostate cancer, from its cellular origins to its clinical manifestations and therapeutic options. In addition to thoroughly covering a variety of diagnostic methods, radical procedures, radiation therapy, hormone therapy, and surgical techniques for prostatectomy, the book seeks to improve the understanding of the development of prostate cancer.

Delving into the latest research and scientific advancements, the book starts by shedding light on the critical role of genetic susceptibility, redox signaling, apoptosis, epigenomics, transcriptomics, and metabolic reprogramming in prostate cancer development and progression. In the following section key concepts in prostate cancer diagnostics are covered. This includes the diagnostic, prognostic, and theranostic potential of miRNAs in prostate cancer; the necessity of biopsy; and the importance of histopathological and molecular markers in assessing aggressivity. It alsoexplores recent advances in tumor markers for early detection and monitoring, as well as biological markers of therapeutic response. The book concludes by offering a wealth of knowledge on current treatment options for prostate cancer, including surgical treatments, hormone therapy for advanced cases, the use of apheresis in personalized cell-mediated treatment, pharmacogenomics and precision therapy challenges and perspectives, stereotactic radiotherapy, and treatment for castration-resistant prostate cancer.

Scientists and medical professionals interested in basic and clinical research in urology and oncology will find this book to be a useful reference. It is a helpful tool for preparing medical specialization in pathology, oncology, urology, clinical biochemistry, laboratory medicine, diagnostic radiology, oncologic radiology, and related fields of cancer research. With its integrative approach to diagnostics and focus on recent scientific breakthroughs, this book empowers readers to deepen their understanding of prostate cancer and enhance their ability to advance basic and clinical research to treat this pervasive disease.

Gordana Kocic, Full Professor of Biochemistry, Medical Faculty University Nis, Serbia.

Professor Gordana Kocic, MD, PhD is a Full Professor of Biochemistry at Medical Faculty University of Nis (Serbia). She is a specialist in medical biochemistry and a subspecialist in three areas of clinical biochemistry: immunoassays, biochemical oncology, and biochemical endocrinology. She is a full member of the Medical Department of the Medical Academy of the Serbian Medical Association, a member of the Scientific Council University of Nis, the Secretary of the Branch of the Academy of the Serbian Medical Association in Niš (Serbia). Professor Gordana Kocic's research has been published in 162 scientific papers in journals from the Journal Citation Report - SCI list, a significant amount of which are in the Q1 category; she is one of authors of textbooks: Biochemistry (Medical Faculty, University of Niš), Clinical Biochemistry (Medical Faculty University of Nis), and Selected Chapters in Urology (Institute for textbooks Belgrade); monographs: "Biochemistry of Free Radicals" and "Oxidative Modification of Biomolecules"; six chapters in monographs of national impact. She presented her scientific achievements published as supplements to prestigious journals. Four registrable patents provide as documentation of innovation activities. The prizes she received are: for PhD thesis, the best scientific articles awarded by the Serbian Medical Society branch Nis, the award for scientific achievement, "Best technological innovation for 2010", by Chamber of Commerce Republic Serbia's.  As a Principal Investigator of the projects of the Ministry of Education and Science Republic of Serbia and Fund of Science Republic of Serbia (No 7750154 (NPATPETTMPCB) and in the NETCHEM project, she has been overseeing and organizing a number of project research activities. She collaborated on two international bilateral projects with Slovenia and TEMPUS projects, Erasmus Plus project,the ERAWEB WB joint mobility program, and the SANU Branch projects.

 Jovan Hadži-Djokić, Full Professor of Urology, Serbian Academy of Science and Arts, Belgrade, Serbia.

 Academician Prof. Jovan Hadži-Djokić, MD, PhD  is a Full Professor of Urology spent almost his entire clinical and academic practice at University Clinical Center Medical Faculty Belgrade (Serbia), being the Director of the Institute of Urology and Nephrology of the Clinical Center of Serbia, a consultant for urology at the Institute of Oncology and Radiology of Serbia, at the Clinic for Gynecology and Obstetrics of the Clinical Center of Serbia. He is a Member of the Serbian Academy of Sciences and Arts since 2003. He trained at the Foch Hospital (Centre Medico Chirurgicale) in Paris (France) and at the University Urology Clinic in Florence (Italy). During his surgical carrier, he introduced new operative techniques into routine urological practice, which made highly respectable within the framework of European and world urology as a scientific discipline. Recognized as a renowned professor, urology expert and scientist, Academician Prof. Jovan Hadzi-Đokic enjoys a reputation in many professional associations through the world, as a member of the editorial boards of numerous journals. He published more than 500 professional-scientific papers, 11 monographs and textbooks in the field of urology: Tumors of the urinary bladder (1995), Angiographic atlas of urological diseases (1995), Urinary stoma (1996), Urgent urology (1997), Urological gynecology (2000), Minimal Invasion Treatment of Urinary Obstruction (2000), Localized prostate cancer ( 2005), Urinary diversions (2009), Urinary incontinence (2009), Erectile dysfunction (2012), Prostate (2014) and Hormones and Prostata (2022). He wrote more than 60 chapters in textbooks and monographsedited by other authors. His scientific opus is characterized by a large number of publications and papers in top international journals related to urology. He is a full member of the Serbian Medical Association, the Serbian Urological Association, the European Association of Urology and the Societe General d'Urologie. He is an honorary member of the Association of Urologists of Romania. He gave more than 80 invited lectures in Serbia and abroad.  For his professional engagement, professional leadership and scientific contributions, he received several awards from various health institutions, organizations and Serbian Government, as well as the October Award of the City of Belgrade for the book Urinary Bladder Tumors. He has been a winner of medal “Karadjordje star of third degree”, which has been awarded by the President of Republic of Serbia for special merits and successes in representing the state and its citizens. As especially admirable person, he was awarded by honorary citizenship from two cities Republic of Serbia.

Tatjana Simić, Full Professor of Biochemistry, Institute of Medical and Clinical Biochemistry Faculty of Medicine, University of Belgrade, Serbian Academy of Science and Arts, Serbia.

Professor Tatjana Simić, MD, PhD is a Full Professor of Medical and Clinical Biochemistry at the Institute of Medical and Clinical Biochemistry, Faculty of Medicine, University of Belgrade, Serbia and a Corresponding member of Serbian Academy of Sciences and Arts. She obtained her PhD in Biochemistry at Faculty of Medicine, University of Belgrade in 1998. She is a Specialist in Clinical Biochemistry and Specialist in Laboratory Medicine. She is a Coordinator of PhD module „Tumor biology and redox medicine" (2016- present), Manager of the Center of excellence for Redox Medicine (2022-present), President of Serbian Proteomic Association (2023- present) and President of the Board for Accreditation of Research institutions of Republic of Serbia (2021-present). She coordinated multiple research projects and participated in numerous collaborative projects. From the very beginning of her scientific career, she has been involved in the research of the role that free radicals and altered mechanisms of antioxidant defense play in disturbed redox homeostasis in various malignant and non-malignant diseases. Regarding her research in the field of urological oncology, her group demonstrated the significance of polymorphisms in genes encoding antioxidant enzymes in susceptibility to urinary tract tumors and their chemoresistance.  She supervised ten PhD candidates. She is an author and coauthor in more than 120 scientific articles referred on SCOPUS, and her h-index is 30. According toSCOPUS her papers were cited more than 3400 times (more than 2900 without auto citations).