No dust jacket. Hardcover. Agents and Actions Supplements Vol. 48. Former owner's name is penned on front endpaper. Upper leading corners of boards are dented and rather bent; upper rear leading corner has minor fabric loss. Spine ends are a little creased. Pages are rather sunned around edges. Binding is sound and pages are tight throughout. Contents are clear. AF.

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Detalles bibliogr�ficos

T�tulo

Prostaglandins And Control Of Vascular Smooth Muscle Cell Proliferation

Editor

Birkhauser Verlag, Basel, Boston, Berlin

Fecha de publicaci�n

1997

Idioma

Ingl�s

ISBN 10

3764356898

ISBN 13

9783764356897

Encuadernaci�n

Hardcover

Estado

Good

Estado de la sobrecubierta

No Dust Jacket

Tipo de libro

Used

Cat�logos de vendedores

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Sinopsis

Uncontrolled proliferation of vascular smooth muscle cells (SMC) in response to vessel injury is a problem with a considerable therapeutic impact. Specifically, restenosis after percutaneous transluminal coronary angioplasty (PTCA) is a clinical problem without any effective drug therapy so far. Thus, there is need for an improved drug therapy but also for an improved understanding of the pathophysiology of growth control in SMC. Cyclooxygenase products, such as prostaglandins and thromboxane, are intimately involved in growth responses. Vasodilatory prostaglandins, such as PGI , PGE or their analogues, have 2 1 been shown to inhibit SMC proliferation. There is also evidence for a markedly increased endogenous prostaglandin production during neointirna formation under the influence of growth factors which includes induction of COX-2. These data suggest that prostaglandins might be considered both targets and tools of growth control. However, there are still many open questions, including the possible interaction of prostaglandins with other growth- modulating factors, in particular NO, the intracellular signal transduction pathways and the role of oxidative stress.

Rese�a del editor

Uncontrolled proliferation of vascular smooth muscle cells (SMC) in response to vessel injury is a problem with a considerable therapeutic impact. Specifically, restenosis after percutaneous transluminal coronary angioplasty (PTCA) is a clinical problem without any effective drug therapy so far. Thus, there is need for an improved drug therapy but also for an improved understanding of the pathophysiology of growth control in SMC. Cyclooxygenase products, such as prostaglandins and thromboxane, are intimately involved in growth responses. Vasodilatory prostaglandins, such as PGI , PGE or their analogues, have 2 1 been shown to inhibit SMC proliferation. There is also evidence for a markedly increased endogenous prostaglandin production during neointirna formation under the influence of growth factors which includes induction of COX-2. These data suggest that prostaglandins might be considered both targets and tools of growth control. However, there are still many open questions, including the possible interaction of prostaglandins with other growth� modulating factors, in particular NO, the intracellular signal transduction pathways and the role of oxidative stress.

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