Pharmacogenetics in Heart Failure: How It Will Shape the Future, An Issue of Heart Failure Clinics, 1e (The Clinics: Internal Medicine). Este artículo no está disponible.Pharmacogenetics in Heart Failure: How It Will Shape the Future, An Issue of Heart Failure Clinics, 1e (The Clinics: Internal Medicine)

Pharmacologic treatment of heart failure has progressed over the last two decades, but regimens have become more complex. With pharmacogenetics, the time is rapidly approaching when information on genetic variability will be used to predict therapeutic response and select the right drug for the right patient. In this issue of Heart Failure Clinics, several leading pioneers of this next revolution in heart failure treatment present the current state-of-the-art on the use of genomic information to target therapeutics. The issue begins with two articles on the basics of what every clinician needs to understand to apply genomic information to patient care and a historical overview of the move toward genetically targeted therapies. The articles that follow address specific therapeutic interventions such as neurohormonal inhibitors and beta blockers. The next series of articles address the genomics of hypertension, left ventricular hypertrophy, and how genomic differences may underlie the apparent racial differences in heart failure and therapeutics. The final third of the issue turns to how genomics will assist treatment of specific clinical scenarios, including myocarditis, transplant rejection, device therapy and pulmonary arterial hypertension. The issue concludes with a discussion of genome-wide association studies.

Charlotte y Peter Fiell son dos autoridades en historia, teoría y crítica del diseño y han escrito más de sesenta libros sobre la materia, muchos de los cuales se han convertido en éxitos de ventas. También han impartido conferencias y cursos como profesores invitados, han comisariado exposiciones y asesorado a fabricantes, museos, salas de subastas y grandes coleccionistas privados de todo el mundo. Los Fiell han escrito numerosos libros para TASCHEN, entre los que se incluyen 1000 Chairs, Diseño del siglo XX, El diseño industrial de la A a la Z, Scandinavian Design y Diseño del siglo XXI.