Next-Gen Blood Purification : Advancing Technologies and Emerging Trends in Hemofiltration and Dialysis

This book provides a comprehensive and multidisciplinary exploration of next-generation extracorporeal blood purification technologies, bridging the gap between cutting-edge research and clinical practice. It offers an in-depth analysis of advanced filtration and adsorption systems, the integration of artificial intelligence for personalized blood purification, and the expanding role of extracorporeal therapies in multi-organ support systems, including ECMO, CRRT, and liver support. Designed for intensivists, nephrologists, anesthesiologists, biomedical engineers, and researchers, this book delivers a scientific yet practical perspective on the latest advances in extracorporeal medicine. It provides detailed discussions on clinical applications, addressing key challenges in managing sepsis, cytokine storms, acute kidney injury, and multi-organ dysfunction. Clinicians will benefit from evidence-based guidelines, clinical case studies, and decision-making algorithms that enhance the implementation of blood purification in critical care settings. Beyond conventional techniques, this work delves into emerging innovations, such as wearable and portable blood purification devices, nanotechnology applications, gene therapy, and artificial organ integration. It also examines regulatory frameworks, ethical considerations, and the global accessibility of these life-saving technologies, making it an invaluable resource for industry professionals and policymakers. By combining scientific rigor, clinical applicability, and future perspectives, this book serves as a definitive reference for healthcare professionals and researchers at the forefront of extracorporeal therapies. It highlights the future of blood purification and its potential to revolutionize critical care, organ support, and personalized medicine.

Silvia De Rosa is an Assistant Professor of Anesthesiology, Intensive Care, and Pain Medicine at the Centre for Medical Sciences (CISMed), University of Trento, Italy. She is also a clinical researcher specializing in Acute Kidney Injury (AKI) and Extracorporeal Organ Support, collaborating with the International Renal Research Institute of Vicenza. Dr. De Rosa serves as the AKI Representative for the Research Committee of the European Society of Intensive Care Medicine (ESICM) and is actively involved in the Italian Society of Anesthesia, Analgesia, and Intensive Care (SIAARTI), where she is Chair and Past Chair of the National Nutrition, Metabolism, and Renal Therapies Section. Her primary research interests include: Acute Kidney Injury (AKI) and Extracorporeal Organ Support; Traumatic Brain Injury (TBI); Clinical Nutrition and Muscle Wasting in Critical Illness; Airway Management in Intensive CareThrough her clinical and academic roles, Dr. De Rosa is dedicated to advancing research in renal therapies, metabolic support, and extracorporeal life support, contributing to the improvement of patient care in intensive care settings.

Sergio Lassola is a researcher specializing in respiratory care, with a particular focus on the management of Acute Respiratory Distress Syndrome (ARDS) and respiratory support strategies for critically ill patients, including those affected by COVID-19. His research also extends to blood purification techniques in intensive care, aiming to improve outcomes in patients with acute kidney injury (AKI) and fluid balance disorders.His key research areas include: Management of ARDS and respiratory failure; Respiratory care in COVID-19 patients; Prone positioning in intensive care; Respiratory system compliance and mechanics; Humidification strategies in mechanical ventilation; Extracorporeal blood purification techniques in critical care; Acute Kidney Injury and Fluid Balance in intensive care. Dr. Lassola is actively involved in scientific communication and professional societies. He is a member of the Communication Committee of the Italian Society of Anesthesia, Analgesia, Resuscitation, and Intensive Care (SIAARTI), contributing to knowledge dissemination and research development in the field of respiratory and extracorporeal therapies. Through his clinical and research work, he is dedicated to advancing critical care medicine, refining ventilatory and extracorporeal strategies, and improving patient outcomes in intensive care settings.