Molecular Determinants of Head and Neck Cancer

Idioma: inglés

Editorial: Springer International Publishing Dez 2018, 2018

3030087794 / 9783030087791

Serie: Libro 19 de 24 - Current Cancer Research

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Librería: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, AlemaniaBuchWeltWeit Ludwig Meier e.K.

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This item is printed on demand - it takes 3-4 days longer - Neuware -Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease. 636 pp. Englisch.…

N° de ref. del artículo 9783030087791

Título
Molecular Determinants of Head and Neck Cancer
Autor
Erica A. Golemis
Editorial
Springer International Publishing Dez 2018
Año de publicación
2018
Estado
Neu
Encuadernación
Taschenbuch
Idioma
inglés
ISBN 10
3030087794
ISBN 13
9783030087791
Edición
2ª Edición
Peso del artículo
949 gramos
Dimensiones
235x155x34 mm
Serie
Libro 19 de 24: Current Cancer Research

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Alemania

Vendedor de 5 estrellas

Vendedor de IberLibro desde 11 de enero de 2012

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BuchWeltWeit Ludwig Meier e.K.

Alemania

BuchWeltWeit Inh. Ludwig Meier e.K.
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