Microfluidic Cell Culture Systems (Micro and Nano Technologies)
Idioma: inglés
Editorial: Elsevier, 2019
- Tapa blanda
- Usado
Librería: killarneybooks, Inagh, Clare, Irlandakillarneybooks
Vendedor de AbeBooks desde 20 de abril de 2017
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EUR 75,50
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Añadir al carritoDescripción del artículo del vendedor
Oversized paperback, second edition, xv + 380 pages, NOT ex-library. Signs of light wear; book is clean and bright with unmarked text, free of inscriptions and stamps, firmly bound. Straight spine. -- This is a technical manual for designing and using Organ-on-a-Chip technology. It focuses on the intersection of microfabrication and cell biology, providing the engineering blueprints needed to create miniature, functional models of human organs. Core Objectives: - Engineering 3D Environments: It explains how to move beyond flat Petri dishes to create 3D micro-environments that mimic the physical and chemical conditions inside the human body; - Disease Modelling: A major focus is the development of specific models for drug toxicity testing and disease progression, particularly for the liver and lung. - Scale-Up for Industry: It addresses the "translation" problem - how to move a delicate microfluidic device from a university lab to a mass-produced industrial tool for pharmaceutical screening. Technical Breakdown: - Micro-scale Physics: The text details how fluids behave at the micron level, focusing on laminar flow, shear stress, and nutrient delivery to living cells. - Biomaterials: It reviews the materials used to build these systems (such as PDMS and other polymers) and how to ensure they are biocompatible so they do not kill the cells they are meant to house. - Multi-Organ Systems: The book explores "Body-on-a-Chip" concepts, where multiple organ models are connected by micro-channels to simulate how a drug might move from the gut to the liver and eventually the bloodstream. It serves as a bridge for engineers who understand fluid dynamics but need to learn cell biology, and for biologists who understand disease but need the hardware to simulate it accurately without using animal models.…
N° de ref. del artículo 013026
- Título
- Microfluidic Cell Culture Systems (Micro and Nano Technologies)
- Autor
- Jeffrey T. Borenstein; Vishal Tandon; Sarah L. Tao; Joseph L. Charest
- Editorial
- Elsevier
- Año de publicación
- 2019
- Estado
- Very Good
- Encuadernación
- Soft cover
- Idioma
- inglés
- ISBN 10
- 0128136715
- ISBN 13
- 9780128136713
- Edición
- 2nd Edition
- Serie
- Libro 165 de 393: Micro and Nano Technologies
Techniques for microfabricating intricate microfluidic structures that mimic the microenvironment of tissues and organs, combined with the development of biomaterials with carefully engineered surface properties, have enabled new paradigms in and cell culture-based models for human diseases. The dimensions of surface features and fluidic channels made accessible by these techniques are well-suited to the size scale of biological cells. Microfluidic Cell Culture Systems applies design and experimental techniques used in in microfluidics, and cell culture technologies to organ-on-chip systems.
This book is intended to serve as a professional reference, providing a practical guide to design and fabrication of microfluidic systems and biomaterials for use in cell culture systems and human organ models. The book covers topics ranging from academic first principles of microfluidic design, to clinical translation strategies for cell culture protocols. The goal is to help professionals coming from an engineering background to adapt their expertise for use in cell culture and organ models applications, and likewise to help biologists to design and employ microfluidic technologies in their cell culture systems.
This 2nd edition contains new material that strengthens the focus on in vitro models useful for drug discovery and development. One new chapter reviews liver organ models from an industry perspective, while others cover new technologies for scaling these models and for multi-organ systems. Other new chapters highlight the development of organ models and systems for specific applications in disease modeling and drug safety. Previous chapters have been revised to reflect the latest advances.
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Acerca del autor
Vishal Tandon is a Research Fellow at the Biomedical Engineering Center, Draper University, USA. His research focuses on the design and testing of implantable microfluidic devices for drug delivery into the ear.
Sarah Tao is Senior Manager, New Technologies at CooperVision, Inc. She was previously Senior Member Technical Staff, MEMS Design Group at Draper University, and Research Professor Equivalent, Bioengineering and Therapeutic Sciences at the University of California, San Francisco, USA. Her research interests lie in the areas of biomaterials, nanotechnology, regenerative medicine, drug delivery, BioMEMS, microfluidics and cell culture.
Dr. Charest is director of in vitro model and organ-assist work at Draper Laboratory. The work of his teams leverages micro- and nano-fabrication along with advanced machining techniques to create systems which recapitulate native tissue and organ architecture, morphology, and function in vitro. The systems span applications from medical devices to screening platforms for pharmaceuticals, and impact fields of use in various organ and tissue types such as tumor, kidney, vascular tissue and lung. Dr. Charest graduated from Georgia Tech with an MS and PhD in Mechanical Engineering and from Penn State with a BS in Mechanical Engineering.
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killarneybooks
Inagh, Clare, Irlanda
Vendedor de AbeBooks desde 20 de abril de 2017
Tarifas de envío de Irlanda a Estados Unidos de America
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All U.S.-bound orders are now shipped with UPS for reliable delivery. Additional customs or import fees are highly unlikely; however, please note buyers remain responsible for any duties or taxes that U.S. Customs may assess. -- Killarneybooks is a family-run bookshop based in the Republic of Ireland. We take pride in accurate listings, careful packaging, and prompt service - most orders ship within 24 hours. All books listed are in stock and ready for immediate dispatch - we are not dropshippers. Inquiries always welcome.…
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