Manual of Neonatal Respiratory Care

Respiratory care is the largest overall component of neonatal intensive care, and the fifth edition of the Manual of Neonatal Respiratory Care is the leading bedside guide for all aspects of respiratory care in the neonatal intensive care unit. Its easy-to-read outline format is simple yet comprehensive and covers all aspects of lung disease in the newborn infant, including embryology, principles of mechanical ventilation, procedures and techniques, monitoring, devices, adjunctive therapies, management of respiratory illness, complications, outcomes, and related issues. 

The latest edition includes fully revised and updated information, coverage on new equipment and devices, and an expanded authorship to enhance its international appeal. The new edition also features two new co-editors, Dr. Mark Mammel and Dr. Anton Van Kaam, internationally recognized experts in the field who bring a fresh perspective to the manual. 

Divided into sixteen sections, the book begins with a section on lung development and maldevelopment, specifically covering the development of the respiratory system, malformations, deformations, disorders of the neonatal airway, and developmental lung anomalies. The second section reviews the principles of mechanical ventilation, with coverage on such topics as spontaneous breathing, oxygen therapy, oxygen toxicity, pulmonary mechanics, and ventilator parameters. The third section of the manual outlines procedures and techniques, including neonatal resuscitation, laryngoscopy and endotracheal intubation, and tracheostomy. The following section dives into the monitoring of the ventilated patient, specifically focusing on continuous monitoring techniques, clinical controversies in pulse oximetry, and echocardiography. The next section spotlights noninvasive ventilatory techniques, such as nasal interfaces, humidified high-flow nasal cannula therapy, and sustained inflation.

The sixth section of the manual focuses on ventilatory modes and modalities, with coverage on intermittent mandatory ventilation, pressure support ventilation, and pressure control ventilation. The following section segues into high-frequency ventilation, reviewing general concepts, high-frequency jet ventilation, and high-frequency oscillatory ventilation. The eighth section centers around commonly used neonatal ventilators, such as the DRAEGER VN500 ventilator, the AVEA ventilator, and the Twinstream ventilator. The ninth section reviews adjunctive therapies, including hemodynamic support, nutritional support, the use of sedation and analgesia, inhaled nitric oxide therapy, and ECMO. The tenth section shifts gears to spotlight the management of common neonatal respiratory diseases, with chapters on mechanisms of respiratory failure, tissue hypoxia, respiratory distress syndrome, persistent pulmonary hypertension, and pulmonary hypoplasia/agensis among others.

Section eleven reviews the etiology, pathogenesis, and management of bronchopulmonary dysplasia, as well as the long-term outcome of newborns with this chronic lung disease. The next section presents complications associated with mechanical ventilation, such as thoracic air leaks, neonatal pulmonary hemorrhage, and neurologic complications. The following two sections spotlights ethical, legal and other considerations, among them nursing care of the ventilated infant, long-term ventilator dependency, home ventilation, withdrawal of ventilatory support, and medical liability and risk management. The fifteenth section focuses on research and literature, with coverage on interpreting medical literature, data collection and assessment of respiratory outcomes, and contemporary classics in neonatal respiratory care. The final section presents ventilatory case studies. 

The text also features over 300 high-yield radiographic images, figures, tables, and algorithms.

Steven M. Donn, MD, FAAP, FAARC

Professor Emeritus of Pediatrics

Division of Neonatal-Perinatal Medicine

C.S. Mott Children’s Hospital

Michigan Medicine

University of Michigan

Ann Arbor, MI

USA

Mark C. Mammel, MD, FAAP

Professor of Pediatrics

University of Minnesota

Minneapolis, MN

USA

Anton H.L.C. Van Kaam, MD, PhD

Professor of Pediatrics

Department of Neonatology

Emma Children’s Hospital

Amsterdam

Netherlands

Dr. Donn is actively involved in teaching, research, and patient care activities. He is a member of numerous professional societies, including elected memberships in the Society for Pediatric Research, the European Society for Pediatric Research, and the American Pediatric Society. He is a Fellow of the American Academy of Pediatrics and chaired its national Committee on Medical Liability and Risk Management, and was named a fellow of the american association forrespiratory care for his notable contributions to the field. He has been chosen as one of the “Best Doctors in America” since 1994, and was selected by Child Magazine in 2001 as one of “Ten Pediatricians Who Make a Difference.” He is internationally known for his expertise in the management of respiratory failure in newborns. He has authored more than 250 medical journal articles, edited 34 books and specialty journals, written 250 book chapters, and has produced numerous educational materials on neonatal respiratory complications, hypoxic-ischemic brain injury, and high-technology respiratory support of the newborn. 

Dr. Donn has been invited internationally to present his research and to teach neonatal intensive care. During his career he has held consulting positions for numerous medical device manufacturers, pharmaceutical companies, and a healthcare management corporation and served on the FDA Specialty Panel for Respiratory and Anesthesia Devices.

Dr. Mammel is currently Professor of Pediatrics at the University of Minnesota, after retiring from clinical practice at Children's Hospitals & Clinics of Minnesota in St Paul. He continues to write, serves as a manuscript reviewer for many journals, and is a member of a number of professional societies, including the Society for Pediatric Research, the American Pediatric Society, and is a fellow of the American Academy of Pediatrics. He has also served as a consultant to the NIH. His career passion has been respiratory care of the newborn infant, and he was a pioneer in the development and study of high frequency ventilation. He was also an early proponent and researcher into the use of neonatal pulmonary graphics and measured lung mechanics to optimize the use of the mechanical ventilator. He has been an international speaker, and has published over 250 scientific papers, book chapters, and abstracts.

Anton van Kaam is currently professor of neonatology and the chief of the neonatalintensive care units at the Emma Children’s Hospital in the Academic Medical Center and the VU university medical center in Amsterdam, The Netherlands. He did his medical and pediatric training in Rotterdam at, respectively, the Erasmus Medical Center and the Sophia Children’s Hospital. Following his certification in 1997 he moved to the Emma Children’s Hospital in Amsterdam, where he did is training in Neonatology until 1999. Since then, he has been working as a consultant in Neonatology and obtained his PhD degree in 2004.

In 2010 he was appointed chief of neonatology at the Emma Children’s Hospital AMC and, in addition, in 2017 at the VU university medical center. In 2014 he was appointed as full professor of neonatology.