Neuware -Microelectrode arrays (MEAs)-based neuronal interfaces allow monitoring and stimulating neuronal networks both in vivo and in vitro. In vitro methodology is widely used to study and model at intermediate complexity learning and memory processes within a large neuronal network. Currently, commercially available MEA platforms for in vitro electrophysiology allow concurrent recording from at most 256 electrodes. However, dissociated neuronal cultures can consist of up to 100'000 cells within a monitored area of a few square millimeters. Thus, substantial spatial subsampling compromises the continuous observation of a large-scale network down to the cellular level. This book demonstrates a new concept for a system that can monitor large dissociated neuronal cultures with 4096 electrodes at high spatial resolutions. The specific objectives are (i) the design of a complete large-scale and high-resolution MEA platform and (ii) the investigation and development of wavelet- and image-based strategies to manage the large data streams with respect to real-time neurophysiological analysis.Books on Demand GmbH, �berseering 33, 22297 Hamburg 192 pp. Deutsch.

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T�tulo: Large-Scale High-Resolution Microelectrode Arrays Neurointerfaces
Editor: S�dwestdeutscher Verlag F�r Hochschulschriften AG Co. KG Jul 2015
Fecha de publicaci�n: 2015
Idioma: Ingl�s
ISBN 10: 3838104730
ISBN 13: 9783838104737
Encuadernaci�n: Taschenbuch
Estado: Neu

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Sinopsis

Microelectrode arrays (MEAs)-based neuronal interfaces allow monitoring and stimulating neuronal networks both in vivo and in vitro. In vitro methodology is widely used to study and model at intermediate complexity learning and memory processes within a large neuronal network. Currently, commercially available MEA platforms for in vitro electrophysiology allow concurrent recording from at most 256 electrodes. However, dissociated neuronal cultures can consist of up to 100'000 cells within a monitored area of a few square millimeters. Thus, substantial spatial subsampling com�promises the continuous observation of a large-scale network down to the cellular level. This book demonstrates a new concept for a system that can monitor large dissociated neuronal cultures with 4096 electrodes at high spatial resolutions. The specific objectives are (i) the design of a complete large-scale and high-resolution MEA platform and (ii) the investigation and development of wavelet- and image-based strategies to manage the large data streams with respect to real-time neurophysiological analysis.

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Kilian Imfeld, Dr. �s sciences: Masters in Electrical Engineering from the Ecole Polytechnique F�d�rale de Lausanne (EPFL) in 1999, R&D engineer in RF Microelectronics for Swatch Group Ltd., Post-graduate degree in Biomedical Engineering from the EPFL in 2003, PhD in Microengineering from the University of Neuch�tel, Switzerland, in 2008.

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