Graham, Ian; Helga Refsum, Irwin H. Rosenberg & Per Magne Ueland (Editors)., Kluwer Academic Publishers, 1997, c1997, brown faux leather with gilt titles (hard cover), fine (as new; no dj), 279 pp with index, B&W diagram illus., small 4to, ISBN: 0792399838, 'The first comprehensive treatise on homocysteine to treat the topic from the basic biochemical, metabolic, genetic, and dietary determinants to disease relationships, including concepts of pathogenesis', 'Developments in Cardiovascular Medicine'.

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Detalles bibliogr�ficos

T�tulo

Homocysteine Metabolism: From Basic Science To Clinical Medicine

Editor

Kluwer Academic Publishers

Fecha de publicaci�n

1997

Idioma

Ingl�s

ISBN 10

0792399838

ISBN 13

9780792399834

Encuadernaci�n

Hardcover

Estado

As New

Estado de la sobrecubierta

No Jacket

Cat�logos de vendedores

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Sinopsis

In 1962, 30 years after the discovery by du Vigneaud have pathologic consequences. One potentially sig� of a new sulfur amino acid, homocysteine; Carson and nificant health outcome of such mild to moderate Neil reported two siblings with mental retardation in hyperhomocysteinemia is an increased risk of occlu� northern Ireland with elevated urinary homocystine. sive vascular disease. Homocysteine concentrations in Nearly simultaneously, Gerritsen and Waisman patients with vascular disease were, on average, 31 % greater than in normal controls. Prospective assess� identified increased homocystine in the urine of a mentally retarded infant in Wisconsin. Within two ment of vascular disease risk among men with higher years, Harvey Mudd, James Finkelstein, and their homocysteine concentrations indicated that plasma coworkers at the National Institutes of health (USA) homocysteine at only 12% above the upper limit of that the enzyme cystathionine ~� normal levels was associated with a 3. 4-fold increase had reported synthase was lacking in a liver biopsy specimen from in risk of acute myocardial infarction. Studies from another patient with homocystinuria. This was the original Framingham Heart Study cohort (USA) the first indication of a vitamin relationship to have shown strong, positive correlation between homocystinuria, because that enzyme has as its co� plasma homocysteine concentration and degree of factor vitamin B6 (pyridoxal phosphate). Thereafter, carotid stenosis.

Cr�ticas

`This book is a good resource for information on homocysteine. It is well organised with short and concise chapters that have lots of diagrams, figures and tables......It is well suited for professionals in the field of cardiology and for those who are basic science researchers wishing a connection with clinical applications.'
K. Cochan, M.D., Loyola University Stritch School of Medicine

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