3540278575. Ernst Schering Research Foundation Workshop 57. Hardcover, from closed pharmaceutical company library. Lending record shows this book has never been borrowed. 232 pages, index, illustrated in colour with charts, tables and diagrams. Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. Contents clean, tight and bright.

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Detalles bibliogr�ficos

T�tulo

The Histone Code and Beyond: New Approaches to Cancer Therapy (Ernst Schering Foundation Symposium Proceedings)

Editor

Springer, Germany

Fecha de publicaci�n

2006

Idioma

Ingl�s

ISBN 10

3540278575

ISBN 13

9783540278573

Encuadernaci�n

Hardcover

Estado

Very Good

Tipo de libro

Book

Cat�logos de vendedores

Medical Research

Acerca de

Sinopsis

Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.

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