Gene Expression in Interspecific Hybrids, II. RNA Synthesis in the Lethal Cross Arbacia Lixula (?) X Paracentrotus lividus (?)
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"This is precisely what Herman Denis did during a stay a few yearslater at Jean Brachet's lab at the LlGBin Naples. He showed thatRNAsynthesized by an interspecific sea urchin hybrid blocked at thegastrula stage is preponderantly paternal, despite the preferentialelimination of paternal chromosomes during egg cleavage. Withelegant saturation and competition experiments using molecularhybridization on filt~rs. he explained the paradox by the existenceof two classes of genes that become active at the onset ofgastrulation, The first and most abundant class of genes, destinedto be expressed at all stages of development, are normally subjectto negative control, which a foreign cytoplasm cannot exert. Thesecond group of genes. which are functional only during the earlydevelopmental stages. fail. on the other hand. to be activated in thesame foreign cytoplasm. These outstanding results already underlinethe full importance of the activation and repression of genesexerting specific control over the stages of morphogenesis. Theywere published in 1969 and 1970, in three papers signed H. Denisand J. Brachet that received much attention."Jean Brachet and his School by HENRI ALEXANDRE Int. J. Dev Biol. 36: 29-41 (1992) First separate edition. Offprint. Original wrappers. Quality, Value, Experience. N° de ref. de la librería DISPLAY5RM1BRACHET
Título: Gene Expression in Interspecific Hybrids, II...
Editorial: Proceedings of the National Academy of Sciences Vol. 62, No.2 pp. 438-445 Feb.
Año de publicación: 1969
Condición del libro: Very Good
Ejemplar firmado: Signed by Author(s)
Edición: 1st Edition
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