Formulation and Development of Bilayer Floating Tablets of Nifedipine

Sharma, Dinesh Kumar; Behera, Amulyaratna; Pattnaik, Gurudutta

ISBN 10: 620341087X ISBN 13: 9786203410877

Editorial: LAP LAMBERT Academic Publishing, 2021

Idioma: Ingl�s

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T�tulo

Formulation and Development of Bilayer Floating Tablets of Nifedipine

Editor

LAP LAMBERT Academic Publishing

Fecha de publicaci�n

2021

Idioma

Ingl�s

ISBN 10

620341087X

ISBN 13

9786203410877

Encuadernaci�n

PAP

Estado

New

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Sinopsis

The aim of the present research work was to develop and formulate a bilayer floating sustained release tablet of Nifedipine. Nifedipine is an antihypertensive agent. Surface solid dispersion of Nifedipine was prepared by solvent evaporation method with different super disintegrants as a polymer for improvement of solubility resulting in improved bioavailability. Bilayer consists of two layers, immediate-release layer, and second sustained release layer, compressed in the single unit dosage form. The immediate-release layer contains surface solid dispersion of Nifedipine. The floating sustained release layer also contains surface solid dispersion of Nifedipine, HPMC K100M & HPMC K15M as sustained release polymer. The floating properties of the tablets were achieved by the use of sodium bicarbonate & citric acid which generate the gas upon contact with gastric fluid. The immediate-release layer releases the drug immediately and starts the onset of action and the floating sustained release layer floats on gastric fluid for upto12 hours and releases the drug in a sustained manner, subsequently, it prolongs the duration of action.

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