Sinopsis
I Motile Dynamics at the Cellular Level - Cytoplasmic Motion and Cell Shape -.- I.1 Embryonic Mesoderm Cells and Larval Keratocytes from Xenopus: Structure and Motility of Single Cells.- I.2 Periodicity in Shape Changes of Human Epidermal Keratinocytes.- I.3 Self-organized F-Actin Autowaves Govern Pseudopodium Projection and the Non-random Locomotion of Dictyostelium Amoebae.- I.4 Mathematical Analysis of Cell Shape.- I.5 Protrusion, Retraction and the Efficiency of Cell Locomotion.- I.6 Microscopic Image Classification Based on Descriptor Analysis.- I.7 A Dynamical Model of Cell Division.- I.8 Shape Behavior of Closed Layered Membranes and Cytokinesis.- I.9 Protrusion-Retraction Dynamics of an Annular Lamellipodial Seam.- I.10 Auto-oscillatory Processes and Feedback Mechanisms in Physarum Plasmodium Motility.- I.11 Origin of Actin-induced Locomotion of Listeria.- I.12 Models for the Formation of Oriented F-actin Structures in the Cytoskeleton.- II Dynamics of Cell Interaction with the Environment.- II.1 Cell-Substratum Interactions of Amoeba proteus: Old and New Open Questions.- II.2 Imaging Traction Stresses.- II.3 Chemotaxis and Chemokinesis of Dictyostelium Amoebae: Different Accumulation Mechanisms Induced by Temporal Signals and Spatial.- II.4 Receptor-mediated Models for Leukocyte Chemotaxis.- II.5 A Model for Cell Migration by Contact Guidance.- II.6 Derivation of a Cell Migration Transport Equation from an Underlying Random Walk Model.- II.7 A Continuum Model for the Role of Fibroblast Contact Guidance in Wound Contraction.- II.8 Wound Healing and Tumour Growth - Relations and Differences -.- III Dynamics of Cell-Cell Interactions - Collective Motion and Aggregation -.- III.1 Models for Spatio-angular Self-organization in Cell Biology.- III.2 Aggregation Induced by Diffusing and Nondiffusing Media.- III.3 Models of Dictyostelium discoideum Aggregation.- III.4 A Cellular Automata Approach to the Modelling of Cell-Cell Interactions.- IV Dynamics within Tissues - Morphogenesis and Plant Movement -.- IV.1 Morphogenetic Dynamics in Tissues: Expectations of Developmental and Cell Biologists.- IV.2 Mechanical Stresses in Animal Development: Patterns and Morphogenetical Role.- IV.3 Mechanisms for Branching Morphogenesis of the Lung.- IV.4 Tissue Stresses in Plant Organs: Their Origin and Importance for Movements.- IV.5 Self-Organization and the Formation of Patterns in Plants.- IV.6 The Mathematics of Plate Bending.- IV.7 Mechanical Forces and Signal Transduction in Growth and Bending of Plant Roots.- IV.8 Growth Field and Cell Displacement within the Root Apex.- IV.9 The Stationary State of Epithelial Tissues.- References.- Group Picture.- Addresses.
Reseña del editor
Understanding the dynamics of cell and tissue motion forms an essential step in understanding the dynamics of life and biological self-organization. Biological motion is one of the most obvious expressions of self-organization, as it requires autonomous creation and regulated action of forces leading to shape formation and translocation of cells and tissues. The topics of the book include intracellular motility and cytoplasma dynamics (e.g. cell division), single cell movement in varying extracellular media (e.g. chemotaxis or contact guidance), cell aggregation and cooperative motion (e.g. cellular swarms or slugs) and, finally, cell-cell interactions in developing tissues (e.g. embryogenesis or plant movement). The dynamics underlying biological motion are explained, on the one hand, by various methods of image processing and correlation analysis, and on the other hand by using physico-chemical theories, developing corresponding mathematical models and performing continuum field or stochastic simulations. Thus, the study is of an interdisciplinary character typically found in theoretical and mathematical biology. Its presentation is intended to reach a broad audience â€" from theoretically interested bioscientists, physicians and biophysicists to applied mathematicians interested in the application of nonlinear dynamical systems and simulation algorithms. The most important feature of the book is that it considers possible synergetic mechanisms of interaction and cooperation on different microscopic levels: on the molecular level of cytoskeletal polymers, membrane proteins and extracellular matrix filaments, as well as on the level of cells and cellular tissues. New results concern the aspects of filament or cell alignment, various modes of force transduction and the formation of global stress fields. The latter aspect of mechanical cell-cell communication is emphasized in order to complement the much more well-studied phenomena of chemical, genetical or electrophysical communication.
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