Dissolution Enhancement Using Different Formulation Approaches: Dissolution Enhancement Of A Poorly Soluble Model Drugs Using Different Formulation Approaches For Immediate Release

Srivastava, Vikas Kumar; Mishra, Garima; Srivastava, Vikas Kumar; Mishra, Garima

ISBN 10: 3659453358 ISBN 13: 9783659453359

Editorial: Lap Lambert Academic Publishing, 2013

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144 pages. 8.66x5.91x0.33 inches. In Stock. N� de ref. del art�culo __3659453358

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The objective of this study was to design Bilayered tablets (SNFML) and to enhance the in vitro release rates. Several techniques were compared for improving the dissolution of model drugs SNFML, poorly soluble drugs. Particle size reduction was realized by jet milling (Micronization of SNML), use of solubility enhancers in the formulation like Klucel-Lf and sodium lauryl sulphate with reduction of surface energy by co-sifting, SNML with lactose showed the immediate release profile when compared with the unmicronized drug. Micronization of SNML enhanced its dissolution rate in Discriminative media (8.2% in 30 min) compared to unmicronized drug (1.3% in 30 min). SNML drug products commercially available on the German, French and Indian markets dissolved similarly to unmicronized SNML, but significantly slower than the micronized drug. The results suggest that Micronization, use of solubility enhancers and reduction of surface energy by co-sifting are powerful ways for the preparation of immediate release formulations of SNFML, and could potentially lead to improvements in the bioavailability of oral SNFML products.

Rese�a del editor: The objective of this study was to design Bilayered tablets (SNFML) and to enhance the in vitro release rates. Several techniques were compared for improving the dissolution of model drugs SNFML, poorly soluble drugs. Particle size reduction was realized by jet milling (Micronization of SNML), use of solubility enhancers in the formulation like Klucel-Lf and sodium lauryl sulphate with reduction of surface energy by co-sifting, SNML with lactose showed the immediate release profile when compared with the unmicronized drug. Micronization of SNML enhanced its dissolution rate in Discriminative media (8.2% in 30 min) compared to unmicronized drug (1.3% in 30 min). SNML drug products commercially available on the German, French and Indian markets dissolved similarly to unmicronized SNML, but significantly slower than the micronized drug. The results suggest that Micronization, use of solubility enhancers and reduction of surface energy by co-sifting are powerful ways for the preparation of immediate release formulations of SNFML, and could potentially lead to improvements in the bioavailability of oral SNFML products.

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T�tulo: Dissolution Enhancement Using Different ...
Editorial: Lap Lambert Academic Publishing
A�o de publicaci�n: 2013
Encuadernaci�n: Paperback
Condici�n: Brand New

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Dissolution Enhancement Using Different Formulation Approaches

Vikas Kumar Srivastava|Garima Mishra

Publicado por LAP LAMBERT Academic Publishing, 2013

ISBN 10: 3659453358 ISBN 13: 9783659453359

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Condici�n: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Srivastava Vikas KumarThe author is Vikas Kumar Srivastava S/o late Om Prakash Srivastava, have completed his B.Pharm (2006-2010) from LIMT, Gr. Noida with 81%. He had completed M.Pharma (Pharmaceutics) from I.T.S Paramedical (Pharma. N� de ref. del art�culo: 5157073

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Dissolution Enhancement Using Different Formulation Approaches | Dissolution Enhancement of a Poorly Soluble Model Drugs Using Different Formulation Approaches for Immediate Release

Vikas Kumar Srivastava (u. a.)

Publicado por LAP LAMBERT Academic Publishing, 2013

ISBN 10: 3659453358 ISBN 13: 9783659453359

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Taschenbuch. Condici�n: Neu. Dissolution Enhancement Using Different Formulation Approaches | Dissolution Enhancement of a Poorly Soluble Model Drugs Using Different Formulation Approaches for Immediate Release | Vikas Kumar Srivastava (u. a.) | Taschenbuch | 144 S. | Englisch | 2013 | LAP LAMBERT Academic Publishing | EAN 9783659453359 | Verantwortliche Person f�r die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabr�ck, mail[at]preigu[dot]de | Anbieter: preigu. N� de ref. del art�culo: 105618249

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Dissolution Enhancement Using Different Formulation Approaches : Dissolution Enhancement of a Poorly Soluble Model Drugs Using Different Formulation Approaches for Immediate Release

Vikas Kumar Srivastava

Publicado por LAP LAMBERT Academic Publishing, 2013

ISBN 10: 3659453358 ISBN 13: 9783659453359

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Taschenbuch. Condici�n: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The objective of this study was to design Bilayered tablets (SNFML) and to enhance the in vitro release rates. Several techniques were compared for improving the dissolution of model drugs SNFML, poorly soluble drugs. Particle size reduction was realized by jet milling (Micronization of SNML), use of solubility enhancers in the formulation like Klucel-Lf and sodium lauryl sulphate with reduction of surface energy by co-sifting, SNML with lactose showed the immediate release profile when compared with the unmicronized drug. Micronization of SNML enhanced its dissolution rate in Discriminative media (8.2% in 30 min) compared to unmicronized drug (1.3% in 30 min). SNML drug products commercially available on the German, French and Indian markets dissolved similarly to unmicronized SNML, but significantly slower than the micronized drug. The results suggest that Micronization, use of solubility enhancers and reduction of surface energy by co-sifting are powerful ways for the preparation of immediate release formulations of SNFML, and could potentially lead to improvements in the bioavailability of oral SNFML products. N� de ref. del art�culo: 9783659453359

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Dissolution Enhancement Using Different Formulation Approaches

Vikas Kumar Srivastava

Publicado por LAP LAMBERT Academic Publishing Sep 2013, 2013

ISBN 10: 3659453358 ISBN 13: 9783659453359

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Taschenbuch. Condici�n: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The objective of this study was to design Bilayered tablets (SNFML) and to enhance the in vitro release rates. Several techniques were compared for improving the dissolution of model drugs SNFML, poorly soluble drugs. Particle size reduction was realized by jet milling (Micronization of SNML), use of solubility enhancers in the formulation like Klucel-Lf and sodium lauryl sulphate with reduction of surface energy by co-sifting, SNML with lactose showed the immediate release profile when compared with the unmicronized drug. Micronization of SNML enhanced its dissolution rate in Discriminative media (8.2% in 30 min) compared to unmicronized drug (1.3% in 30 min). SNML drug products commercially available on the German, French and Indian markets dissolved similarly to unmicronized SNML, but significantly slower than the micronized drug. The results suggest that Micronization, use of solubility enhancers and reduction of surface energy by co-sifting are powerful ways for the preparation of immediate release formulations of SNFML, and could potentially lead to improvements in the bioavailability of oral SNFML products.VDM Verlag, Dudweiler Landstra�e 99, 66123 Saarbr�cken 144 pp. Englisch. N� de ref. del art�culo: 9783659453359

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Dissolution Enhancement Using Different Formulation Approaches

Vikas Kumar Srivastava

Publicado por LAP LAMBERT Academic Publishing Sep 2013, 2013

ISBN 10: 3659453358 ISBN 13: 9783659453359

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Taschenbuch. Condici�n: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The objective of this study was to design Bilayered tablets (SNFML) and to enhance the in vitro release rates. Several techniques were compared for improving the dissolution of model drugs SNFML, poorly soluble drugs. Particle size reduction was realized by jet milling (Micronization of SNML), use of solubility enhancers in the formulation like Klucel-Lf and sodium lauryl sulphate with reduction of surface energy by co-sifting, SNML with lactose showed the immediate release profile when compared with the unmicronized drug. Micronization of SNML enhanced its dissolution rate in Discriminative media (8.2% in 30 min) compared to unmicronized drug (1.3% in 30 min). SNML drug products commercially available on the German, French and Indian markets dissolved similarly to unmicronized SNML, but significantly slower than the micronized drug. The results suggest that Micronization, use of solubility enhancers and reduction of surface energy by co-sifting are powerful ways for the preparation of immediate release formulations of SNFML, and could potentially lead to improvements in the bioavailability of oral SNFML products. 144 pp. Englisch. N� de ref. del art�culo: 9783659453359

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