On Disorders of Assimilation, Digestion, Etc (Classic Reprint)
Idioma: inglés
Editorial: Forgotten Books, 2018
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N° de ref. del artículo ERICA82304840117666
- Título
- On Disorders of Assimilation, Digestion, Etc (Classic Reprint)
- Autor
- Brunton, Thomas Lauder
- Editorial
- Forgotten Books
- Año de publicación
- 2018
- Estado
- New
- Tipo de libro
- book
- Encuadernación
- hardcover
- Idioma
- inglés
- ISBN 10
- 0484011766
- ISBN 13
- 9780484011761
The fact that such digestion actually does occur, and the observa tion that microbes have the power of modifying the enzymes they produce in accordance with the media upon which they grow, appear to afford an indication that the phenomenon of infective disease and microbes are due to digestion within the tissues by the enzymes formed by microbes. Further, that the increasing virulence of microbes growing in favourable media is due to an increased power of producing enzymes, whilst the acquired resistance of the tissues is probably due to an extension to them of the power of resistance to toxic substances naturally possessed by the intestine and liver. The paper on atropine in cholera shows the practical result of an attempt to cure infective disease by the use of an alkaloid antagonistic to one which, as I pointed out twenty-five years ago, could produce symptoms similar to the disease, and which alkaloid has now been shown to be a common product of the bacterial decom position of proteid substances. With the assistance of Dr. Rhodes, I again took up the question of glycolytic enzyme in muscle, and we have been able to confirm my earlier results by more perfect experiments, but we have not yet succeeded in isolating this enzyme. The clumping of bacilli as a question of re-action is interesting both theoretically and practically. Most of the other papers are clinical and practical in character.
Had time and opportunity permitted, 1 should have liked to combine these fragmentary researches into a coherent whole by other experiments, but other demands upon my time prevent my doing more than collecting them into one book from the scattered publications in which they have appeared. The leading idea of many of them is the action of enzymes, and the recognition of their importance I owe to my teacher and friend, Professor Kuhne, who impressed it upon me both by his lectures and conversation when I was working in his laboratory in Amsterdam in 1868 - 69. At that time he had clearly grasped the idea not only of enzymes, but of zymogens, and stated that both in the stomach and pancreas substances existed, which, though not themselves enzymes or ferments were capable of yielding active ferments. How much I owe to hls teaching it is impossible for me to express, and although the world at large must mourn his loss, only those who knew intimately his person and work know how great that loss is.
About the Publisher
Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com
This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.
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Reseña del editor
The fact that such digestion actually does occur, and the observa tion that microbes have the power of modifying the enzymes they produce in accordance with the media upon which they grow, appear to afford an indication that the phenomenon of infective disease and microbes are due to digestion within the tissues by the enzymes formed by microbes. Further, that the increasing virulence of microbes growing in favourable media is due to an increased power of producing enzymes, whilst the acquired resistance of the tissues is probably due to an extension to them of the power of resistance to toxic substances naturally possessed by the intestine and liver. The paper on atropine in cholera shows the practical result of an attempt to cure infective disease by the use of an alkaloid antagonistic to one which, as I pointed out twenty-five years ago, could produce symptoms similar to the disease, and which alkaloid has now been shown to be a common product of the bacterial decom position of proteid substances. With the assistance of Dr. Rhodes, I again took up the question of glycolytic enzyme in muscle, and we have been able to confirm my earlier results by more perfect experiments, but we have not yet succeeded in isolating this enzyme. The clumping of bacilli as a question of re-action is interesting both theoretically and practically. Most of the other papers are clinical and practical in character.
Had time and opportunity permitted, 1 should have liked to combine these fragmentary researches into a coherent whole by other experiments, but other demands upon my time prevent my doing more than collecting them into one book from the scattered publications in which they have appeared. The leading idea of many of them is the action of enzymes, and the recognition of their importance I owe to my teacher and friend, Professor Kuhne, who impressed it upon me both by his lectures and conversation when I was working in his laboratory in Amsterdam in 1868 - 69. At that time he had clearly grasped the idea not only of enzymes, but of zymogens, and stated that both in the stomach and pancreas substances existed, which, though not themselves enzymes or ferments were capable of yielding active ferments. How much I owe to hls teaching it is impossible for me to express, and although the world at large must mourn his loss, only those who knew intimately his person and work know how great that loss is.
About the Publisher
Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com
This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.
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