Development of a New Computational Approach to the Prediction of Nucleic Acid

Idioma: inglés

Editorial: Forgotten Books, 2024

1333716362 / 9781333716363

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Librería: Forgotten Books, London, Reino UnidoForgotten Books

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Print on Demand. This book presents the development of a novel computational approach to predict the three-dimensional structure of deoxyribose nucleic acids by potential energy methods. The significance of the approach lies in its ability to incorporate experimental data known from crystal structures of small molecules, and to make reliable predictions of structures of larger biological systems. The author's strategy consists of representing the molecular conformation in cartesian coordinate space with the full set of degrees of freedom associated with the molecular conformation, allowing all bond lengths and bond angles as well as dihedral angles to vary. All the interactions other than the non-bonded terms are represented by polynomials of the coordinate variables. This formulation allows direct differentiation with respect to the cartesian variables and facilitates manipulation and differentiation of the energy terms. The text examines in detail the influence of different potential energy sets on the structures obtained and on the C3' endo/C2' endo energy difference. The author explores the contribution of each energy potential from Energy versus P (the pseudorotation parameter) profiles. These curves also provide an opportunity to investigate the approximation made in the pseudorotation description. The concluding insights of this book are significant because they provide a deeper understanding of the correlation between conformation and biological function, offering a valuable tool for revealing details of molecular conformation, motion, and associated biological functions. This book is a reproduction of an important historical work, digitally reconstructed using state-of-the-art technology to preserve the original format. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in the book.…

N° de ref. del artículo 9781333716363_0

Título
Development of a New Computational Approach to the Prediction of Nucleic Acid
Autor
Tamar Schlick, Charles Peskin
Editorial
Forgotten Books
Año de publicación
2024
Estado
New
Tipo de libro
print-on-demand item
Encuadernación
Paperback
Idioma
inglés
ISBN 10
1333716362
ISBN 13
9781333716363
Catálogos de vendedores
Calculus

Forgotten Books

London, Reino Unido

Vendedor de 5 estrellas

Vendedor de IberLibro desde 2 de junio de 2021

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ArtículoDe 5 a 10 días hábilesDe 5 a 10 días hábiles
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Forgotten Books’ Classic Reprint Series utilizes the latest technology to regenerate facsimiles of historically important writings. Careful attention has been made to accurately preserve the original format of each page whilst digitally enhancing the quality of the aged text.

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FB &c Ltd

Dalton House, 60 Windsor Avenue
London, Reino Unido SW19 2RR