Crossing the Boundaries of Life

Karl S. Matlin

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Idioma: inglés

Editorial: The University of Chicago Press, US, 2022

0226819345 / 9780226819341

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A close look at Günter Blobel's transformative contributions to molecular cell biology. The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl S. Matlin argues in Crossing the Boundaries of Life, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cell biologist, the Nobel laureate Günter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to target newly made proteins to cell membrane vesicles, enabling him to theorize how proteins in the cell distribute spatially, an idea he called the signal hypothesis. Over the next twenty years, Blobel and other scientists were able to dissect this mechanism into its precise molecular details. For elaborating his signal concept into a process he termed membrane topogenesis-the idea that each protein in the cell is synthesized with an "address" that directs the protein to its correct destination within the cell-Blobel was awarded the Nobel Prize in Physiology or Medicine in 1999. Matlin argues that Blobel's investigative strategy and its subsequent application addressed a fundamental unresolved dilemma that had bedeviled biology from its very beginning-the relationship between structure and function-allowing biology to achieve mechanistic molecular explanations of biological phenomena. Crossing the Boundaries of Life thus uses Blobel's research and life story to shed light on the importance of cell biology for twentieth-century science, illustrating how it propelled the development of adjacent disciplines like biochemistry and molecular biology.…

N° de ref. del artículo LU-9780226819341

Título
Crossing the Boundaries of Life
Autor
Karl S. Matlin
Editorial
The University of Chicago Press, US
Año de publicación
2022
Estado
New
Encuadernación
Paperback
Idioma
inglés
ISBN 10
0226819345
ISBN 13
9780226819341
Peso del artículo
426 gramos

Rarewaves.com USA

London, London, Reino Unido

Vendedor de 5 estrellas

Vendedor de IberLibro desde 11 de junio de 2025

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