Cloastrida: Molecular Biology and Pathogens. Este artículo no está disponible.Cloastrida: Molecular Biology and Pathogens

The clostridia are a group of bacteria of considerable medical and economic importance and include species responsible for generating the most potent toxins known to humans. The Clostridia: Molecular Biology and Pathogenesis is a unique work, comprising the most complete reference on the clostridia for over 20 years, bringing together the results from some of the most innovative and exciting research in the past decade. Using a principle-oriented rather than taxonomic approach, the results from molecular biology research are placed in the context of their clinical significance, and the disease process as a whole. This state-of-the-art work is truly comprehensive, covering and integrating the diverse topics of genetics, physiology, pathogenesis and cell biology. Written and edited by world-renowned authorities, material is presented to give the reader an up-to-date knowledge of the pathogenic species of this important genus. Background information is followed by details of the genetics, molecular biology, biochemistry and disease mechanisms. The structure, function and mode of action of toxins and other virulence determinants is clearly presented. As such, this work will prove essential for students, teachers, research microbiologists, infectious disease clinicians, toxin specialists, and all those working in medical or veterinary bacteriology, microbial genetics and the pharmaceutical industries.

Julian I. Rood is a Reader in Microbiology at Monash University in Melbourne, Australia. He is a Fellow of both the Australian Society for Microbiology and the American Academy of Microbiology. His research career has focused on the development of the genetics of Clostridium perfringens, the use of molecular genetics to study the regulation of toxin production and the pathogenesis of clostridial myonecroses, and the genetic analysis of clostridial antibiotic resistance determinants.

Bruce A. McClane is currently an Associate Professor in the Department of Molecular Genetics and Biochemistry at the University of Pittsburgh School of Medicine, (Pittsburgh, Pennsylvania). His primary research interest is concerned with the role of toxins in bacterial pathogenesis, with a particular emphasis on understanding the action and genetics of Clostridium perfringens enterotoxin.

J. Glenn Songer is a Professor of Veterinary Science and Microbiology at the University of Arizona (Tucson, Arizona). His research is directed to understanding the pathogenesis of infections by Gram-positive bacteria, including Clostridium perfringens, Corynebacterium pseudotuberculosis and Actinomyces pyogenes. In addition, he has interests in the application of molecular and immunologic methods in diagnostic veterinary microbiology.

Richard W. Titball is the Technical Manager for Microbiology at the Defence Evaluation and Research Agency, Porton Down. He has worked on the pathogenic clostridia for the past eight years. His other research interests include the developments of vaccines against other bacterial pathogens, and he holds a number of patents in the area.