Clinical Guidelines for sperm DNA Fragmentation of Male Infertility : Association for IRIFIV-AISRG. First Edition 2021

Idioma: inglés

Editorial: LAP LAMBERT Academic Publishing, 2021

6203870544 / 9786203870541

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Librería: AHA-BUCH GmbH, Einbeck, AlemaniaAHA-BUCH GmbH

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Vendedor de IberLibro desde 14 de agosto de 2006

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nach der Bestellung gedruckt Neuware - Printed after ordering - Description:Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction and protects the genetic content. Testicular (defective maturation and abortive apoptosis) and post-testicular (oxidative stress) mechanisms are implicated in the etiology of sperm DNA fragmentation (SDF), which affects both natural and assisted reproduction. Several clinical and environmental factors are known to negatively impact sperm DNA integrity. An increasing number of reports emphasizes the direct relationship between sperm DNA damage and male infertility. Currently, several assays are available to assess sperm DNA damage, however, routine assessment of SDF in clinical practice is not recommended by professional organizations. This article provides an overview of SDF types, origin and comparative analysis of various SDF assays while primarily focusing on the clinical indications of SDF testing. Importantly, we report four clinical cases where SDF testing had played a significant role in improving fertility outcome. Description:Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction and protects the genetic content. Testicular (defective maturation and abortive apoptosis) and post-testicular (oxidative stress) mechanisms are implicated in the etiology of sperm DNA fragmentation (SDF), which affects both natural and assisted reproduction. Several clinical and environmental factors are known to negatively impact sperm DNA integrity. An increasing number of reports emphasizes the direct relationship between sperm DNA damage and male infertility. Currently, several assays are available to assess sperm DNA damage, however, routine assessment of SDF in clinical practice is not recommended by professional organizations. This article provides an overview of SDF types, origin and comparative analysis of various SDF assays while primarily focusing on the clinical indications of SDF testing. Importantly, we report four clinical cases where SDF testing had played a significant role in improving fertility outcome.…

N° de ref. del artículo 9786203870541

Título
Clinical Guidelines for sperm DNA Fragmentation of Male Infertility : Association for IRIFIV-AISRG. First Edition 2021
Autor
Mustafa Zakaria
Editorial
LAP LAMBERT Academic Publishing
Año de publicación
2021
Estado
Neu
Encuadernación
Taschenbuch
Idioma
inglés
ISBN 10
6203870544
ISBN 13
9786203870541
Peso del artículo
352 gramos
Dimensiones
220x150x15 mm

AHA-BUCH GmbH

Einbeck, Alemania

Vendedor de 5 estrellas

Vendedor de IberLibro desde 14 de agosto de 2006

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