Big Data in Omics and Imaging : Integrated Analysis and Causal Inference

Idioma: inglés

Editorial: CRC Press Jun 2018, 2018

0815387105 / 9780815387107

Serie: Libro 4 de 50 - Chapman & Hall/CRC Computational Biology Series

Librería: AHA-BUCH GmbH, Einbeck, AlemaniaAHA-BUCH GmbH

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Descripción del artículo del vendedor

Neuware - Big Data in Omics and Imaging: Integrated Analysis and Causal Inference addresses the recent development of integrated genomic, epigenomic and imaging data analysis and causal inference in big data era. Despite significant progress in dissecting the genetic architecture of complex diseases by genome-wide association studies (GWAS), genome-wide expression studies (GWES), and epigenome-wide association studies (EWAS), the overall contribution of the new identified genetic variants is small and a large fraction of genetic variants is still hidden. Understanding the etiology and causal chain of mechanism underlying complex diseases remains elusive. It is time to bring big data, machine learning and causal revolution to developing a new generation of genetic analysis for shifting the current paradigm of genetic analysis from shallow association analysis to deep causal inference and from genetic analysis alone to integrated omics and imaging data analysis for unraveling the mechanism of complex diseases.FEATURES - Provides a natural extension and companion volume to Big Data in Omic and Imaging: Association Analysis, but can be read independently. - Introduce causal inference theory to genomic, epigenomic and imaging data analysis - Develop novel statistics for genome-wide causation studies and epigenome-wide causation studies. - Bridge the gap between the traditional association analysis and modern causation analysis - Use combinatorial optimization methods and various causal models as a general framework for inferring multilevel omic and image causal networks - Present statistical methods and computational algorithms for searching causal paths from genetic variant to disease - Develop causal machine learning methods integrating causal inference and machine learning - Develop statistics for testing significant difference in directed edge, path, and graphs, and for assessing causal relationships between two networks The book is designed for graduate students and researchers in genomics, epigenomics, medical image, bioinformatics, and data science. Topics covered are: mathematical formulation of causal inference, information geometry for causal inference, topology group and Haar measure, additive noise models, distance correlation, multivariate causal inference and causal networks, dynamic causal networks, multivariate and functional structural equation models, mixed structural equation models, causal inference with confounders, integer programming, deep learning and differential equations for wearable computing, genetic analysis of function-valued traits, RNA-seq data analysis, causal networks for genetic methylation analysis, gene expression and methylation deconvolution, cell -specific causal networks, deep learning for image segmentation and image analysis, imaging and genomic data analysis, integrated multilevel causal genomic, epigenomic and imaging data analysis.…

N° de ref. del artículo 9780815387107

Título
Big Data in Omics and Imaging : Integrated Analysis and Causal Inference
Autor
Momiao Xiong
Editorial
CRC Press Jun 2018
Año de publicación
2018
Estado
Neu
Encuadernación
Buch
Idioma
inglés
ISBN 10
0815387105
ISBN 13
9780815387107
Peso del artículo
1411 gramos
Dimensiones
241x164x43 mm
Serie
Libro 4 de 50: Chapman & Hall/CRC Computational Biology Series

AHA-BUCH GmbH

Einbeck, Alemania

Vendedor de 5 estrellas

Vendedor de IberLibro desde 14 de agosto de 2006

Tarifas de envío de Alemania a Estados Unidos de America

ArtículoDe 7 a 10 días hábilesDe 5 a 7 días hábiles
Primer artículoEUR 44,88EUR 61,93
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