This item is printed on demand - it takes 3-4 days longer - Neuware -Allosteric Modulation of G Protein-Coupled Receptors reviews fundamental information on G protein-coupled receptors (GPCRs) and allosteric modulation, presenting original research in the area and collectively providing a comprehensive description of key issues in GPCR allosteric modulation. The book provides background on core concepts of molecular pharmacology while also introducing the most important advances and studies in the area. It also discusses key methodologies. This is an essential book for researchers and advanced students engaged in pharmacology, toxicology and pharmaceutical sciences training and research. Many of the GPCR-targeted drugs released in the past decade have specifically worked via allosteric mechanisms. Unlike direct orthosteric-acting compounds that occupy a similar receptor site to that of endogenous ligands, allosteric modulators alter GPCR-dependent signaling at a site apart from the endogenous ligand. Recent methodological and analytical advances have greatly improved our ability to understand the signaling mechanisms of GPCRs. We now know that allostery is a common regulatory mechanism for all GPCRs and not - as we once believed - unique to a few receptor subfamilies. 212 pp. Englisch.

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T�tulo: Allosteric Modulation of G Protein-Coupled Receptors
Editor: Elsevier Science Feb 2022
Fecha de publicaci�n: 2022
Idioma: Ingl�s
ISBN 10: 0128197714
ISBN 13: 9780128197714
Encuadernaci�n: Taschenbuch
Estado: Neu
Dimensiones: 229�mil�metros de ancho por 152 de alto por 10 de largo
Peso: 360 gramos

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Allosteric Modulation of G Protein-Coupled Receptors reviews fundamental information on G protein-coupled receptors (GPCRs) and allosteric modulation, presenting original research in the area and collectively providing a comprehensive description of key issues in GPCR allosteric modulation. The book provides background on core concepts of molecular pharmacology while also introducing the most important advances and studies in the area. It also discusses key methodologies. This is an essential book for researchers and advanced students engaged in pharmacology, toxicology and pharmaceutical sciences training and research. Many of the GPCR-targeted drugs released in the past decade have specifically worked via allosteric mechanisms. Unlike direct orthosteric-acting compounds that occupy a similar receptor site to that of endogenous ligands, allosteric modulators alter GPCR-dependent signaling at a site apart from the endogenous ligand. Recent methodological and analytical advances have greatly improved our ability to understand the signaling mechanisms of GPCRs. We now know that allostery is a common regulatory mechanism for all GPCRs and not – as we once believed – unique to a few receptor subfamilies.

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Robert Laprairie is the GlaxoSmithKline-Canadian Institutes of Health Research chair in Drug Discovery and Development in the College of Pharmacy and Nutrition at the University of Saskatchewan. He currently serves as the President and Director of Education and Trainee Initiatives for the Canadian Consortium for the Investigation of Cannabinoids (CCIC). His teaching responsibilities include basic molecular pharmacology and neuroscience in the undergraduate and graduate Pharmacy programs. He is also involved in committee work with the Canadian Institutes of Health Research and the Animal Research Ethics Board of the University of Saskatchewan. Dr. Laprairie has published more than 50 articles on pharmacology with a focus on the endocannabinoid system and allosteric modulators.

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