Nuclear Factor кB: Regulation and Role in Disease - Tapa blanda

 
9789401039833: Nuclear Factor кB: Regulation and Role in Disease
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ISBN 10: 9401039836 ISBN 13: 9789401039833
Editorial: Springer, 2012

Sinopsis

Seventeen years after its initial description, nuclear factor-KB (NF-KB) endures as one of the most studied transcription factors.

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Reseña del editor

Seventeen years after its initial description, nuclear factor-KB (NF-KB) endures as one of the most studied transcription factors. NF-KB has attracted widespread interest based on the variety of stimuli that activate it, the diverse genes and bio­ logical responses that it controls, the striking evolutionary conservation of struc­ ture and function among species, and its involvement in a variety of human diseases. The biochemical basis by which several stimuli converge to activate NF-KB has been largely elucidated during recent years. While first discovered as a key regulatory factor of the immune system, NF-KB is now recognized as an important player in the functioning of many organs and cell types. The ongoing examination of NF-KB signaling has revealed its ever expanding role in immune and inflammatory responses, but also in cancer and development. For this reason, numerous efforts are underway to develop safe inhibitors of NF-KB to be used in the treatment of both chronic and acute disease situations. The present book is the first to review and synthesize our knowledge of this interesting transcription factor. As such, the choice of subjects to review was daunting. To set the stage, an introductory chapter on activators and target genes, as well as the role they play in several responses, has been included.

Reseña del editor

The transcription factor NF-kappaB and the signaling pathways regulating its activity constitute a paradigm of membrane to nucleus communication. NF-kappaB is central to a number of cellular functions including cell proliferation, apoptosis, and cellular differentiation. This transcription factor also plays essential roles in innate and acquired immunity, and its deregulation leads to important human diseases such as inflammation and cancer. Therefore NF-kappaB, together with the signaling pathways leading to its activation, constitute an attractive therapeutic target. This book is the first to review and synthesize our knowledge on this interesting transcription factor. It will be of great interest for those entering or already actively working in the NF-kappaB field, as well as a valuable reference for students, established researchers, or clinicians with wider interests in the fields of molecular cell biology and biomedicine.

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Editorial
Springer
Año de publicación
2012
Idioma
Inglés
ISBN 10 
9401039836
ISBN 13 
9789401039833
Encuadernación
Tapa blanda
Número de páginas
440
Editor
Beyaert R.
Contacto del fabricante
no disponible
Persona responsable
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Alemania

Otras ediciones populares con el mismo título

9781402014345: Nuclear Factor кB: Regulation and Role in Disease

Edición Destacada

ISBN 10:  1402014341 ISBN 13:  9781402014345
Editorial: Springer, 2003
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