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Formulation and Optimization of Transdermal Patches: A brief study - Tapa blanda

Rani, Mukesh; Rohilla, Seema

 
9786208427764: Formulation and Optimization of Transdermal Patches: A brief study
Tapa blanda
ISBN 10: 6208427762 ISBN 13: 9786208427764
Editorial: LAP Lambert Academic Publishing, 2025

Sinopsis

Lisinopril is an antihypertensive agent indicated for the prevention of hypertension, acute myocardial infarction and diabetic nephropathy. It is an angiotensin converting enzyme(ACE) inhibitor. It has a short half-life and undergoes variable first pass metabolism. It is required to be administered two or three times daily which results in poor patient compliance. In this work an attempt was made to formulate & evaluate TDDS for sustained release of lisinopril by solvent evaporation method. Low molecular weight, good permeability and shorter half-life of the drug made it a suitable candidate for the development of trans dermal patch.The main objective of formulating the transdermal system was to prolong the drug release time, reduce the frequency of administration and to improve patient compliance. The compatibility characterization was done by IR method. By using 32factorial design nine formulations were prepared using hydrophilic (HPMC) andhydrophobic (ethyl cellulose) polymers along with selected plasticizer & permeationenhancer. PVA backing membrane was used as a substrate for pouring the polymeric solution. The prepared patches were evaluated for physical appearance, thickness.

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Editorial
LAP Lambert Academic Publishing
Año de publicación
2025
Idioma
Inglés
ISBN 10 
6208427762
ISBN 13 
9786208427764
Encuadernación
Tapa blanda
Número de páginas
188
Contacto del fabricante
no disponible
Persona responsable
no disponible