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Understanding Amyotrophic Lateral Sclerosis: Causes and Management: Understanding Causes, Managing Care,and Exploring Treatment Advances inAmyotrophic Lateral Sclerosis - Tapa blanda

El-Banna, Mona

 
9786208420321: Understanding Amyotrophic Lateral Sclerosis: Causes and Management: Understanding Causes, Managing Care,and Exploring Treatment Advances inAmyotrophic Lateral Sclerosis
Tapa blanda
ISBN 10: 6208420326 ISBN 13: 9786208420321
Editorial: LAP LAMBERT Academic Publishing, 2025

Sinopsis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder marked by muscle weakness, atrophy, fasciculations, and spasticity due to motor neuron degeneration. Symptoms progress from focal weakness to difficulties in speaking, swallowing, and breathing, with eventual paralysis. The disease arises from mechanisms such as disrupted RNA metabolism (e.g., TDP-43 and FUS mutations), cytoskeletal and axonal transport defects (e.g., PFN1, TUBA4A mutations), excitotoxicity, and oxidative stress. While incurable, treatments like Riluzole and Edaravone can modestly slow progression, and supportive care—such as non-invasive ventilation, feeding tubes, and physical therapy—helps manage symptoms. Emerging therapies, including gene and RNA-targeted approaches, hold promise for the future.

"Sinopsis" puede pertenecer a otra edición de este libro.

Editorial
LAP LAMBERT Academic Publishing
Año de publicación
2025
Idioma
Inglés
ISBN 10 
6208420326
ISBN 13 
9786208420321
Encuadernación
Tapa blanda
Número de páginas
60
Contacto del fabricante
no disponible
Persona responsable
no disponible