NEW METHOD DEVELOPMENT AND VALIDATION OF BEMPEDOIC ACID - Tapa blanda

Karanam, Sridevi Ranjitha; Yarguntla, Srinivasa Rao; Kollabatthula, Vara Prasada Rao

 
9786208223564: NEW METHOD DEVELOPMENT AND VALIDATION OF BEMPEDOIC ACID
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ISBN 10: 6208223563 ISBN 13: 9786208223564
Editorial: LAP LAMBERT Academic Publishing, 2024

Sinopsis

A Visible Spectrophotometric method has been developed and validated for the quantitative measurement of Bempedoic acid in bulk and tablet dosage forms. The process is based on the production of a colored complex in the presence of Ferric chloride between Bempedoic acid and MBTH (3-methyl-2-benzothiazolinone Hydrazone). At 663 nm, the colored complex was spectrophotometrically measured. The correlation coefficient (r2) of 0.999 revealed that the approach is linear in the concentration range of 10-60 µg/mL. It was discovered that the limits of detection (LOD) and quantitation (LOQ) were 2.169 µg/mL and 6.572 µg/mL, respectively. For both intra-day and inter-day precision studies, the approach was proven to be precise with a percent relative standard deviation (%RSD) less than 2.0%. Recovery experiments were used to assess the method's accuracy, and it was discovered that the average percentage of recovery fell between 98.0 and 102.0%. The results of the suggested approach were compared to those of the reference method for the accurate determination of Bempedoic acid in tablet dosage forms.

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Editorial
LAP LAMBERT Academic Publishing
Año de publicación
2024
Idioma
Inglés
ISBN 10 
6208223563
ISBN 13 
9786208223564
Encuadernación
Tapa blanda
Número de páginas
76
Contacto del fabricante
no disponible
Persona responsable
no disponible