Formulation, Development of Mesalamine Tablet for Colon Targeting: Mesalamine Tablet for Colon Targeting - Tapa blanda

Shinde, Anilkumar; Tamboli, Firoj; More, Harinath

 
9786208170691: Formulation, Development of Mesalamine Tablet for Colon Targeting: Mesalamine Tablet for Colon Targeting
Tapa blanda
ISBN 10: 6208170699 ISBN 13: 9786208170691
Editorial: LAP LAMBERT Academic Publishing, 2024

Sinopsis

The objective of present work was to prepare colon-specific delivery systems for 5-aminosalicylic acid (5-ASA) using fenugreek gum and chitosan as a carrier target to the colon. Methods: Core tablets containing 5-ASA were prepared by wet granulation with using polyvinyl pyrolidone (PVP) as a binder and sodium starch glycolate as a super disintegrant. The prepared granules were evaluated for the angle of repose, compressibility index and Hausner’s ratio. The prepared tablets were evaluated the hardness, friability, weight variation and disintegration studies. The core tablets were coated with the concentration of 2%, 5%, and 7% in the ratio of 50:50, 40:60, 60:40, 70:30 and 30:70 of fenugreek gum and chitosan. The enteric coated tablets were characterized for the in vitro disintegration, and dissolution. The drug polymer compatibility studies were determined by using FT-IR study and found out no interaction between the drug and polymers. Results: The formation of complexes between fenugreek gum and chitosan prevents the drug release in the stomach. The tablets coated with 7% concentration solutions in the ratio 70:30 (Fenugreek gum: Chitosan) shows better swelling property.

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Editorial
LAP LAMBERT Academic Publishing
Año de publicación
2024
Idioma
Inglés
ISBN 10 
6208170699
ISBN 13 
9786208170691
Encuadernación
Tapa blanda
Número de páginas
56
Contacto del fabricante
no disponible
Persona responsable
no disponible