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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques - Tapa blanda
Sinopsis
Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 μg/ml) limits its bioavailability. This study aimed to improve Irbesartan’s solubility through solid dispersions using carriers like β-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. β-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug’s transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that β-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using β-cyclodextrin in solid dispersions effectively enhances Irbesartan’s solubility and therapeutic potential in treating hypertension.
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Publicado por
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
Nuevo
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Librería: Ria Christie Collections, Uxbridge, Reino Unido
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Publicado por
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
Nuevo
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Librería: California Books, Miami, FL, Estados Unidos de America
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Enhancing Irbesartan Bioavailability via Solid Dispersion
Publicado por
LAP LAMBERT Academic Publishing Sep 2024, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
Nuevo
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Librería: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Alemania
Calificación del vendedor: 5 de 5 estrellas
Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 84 pp. Englisch. Nº de ref. del artículo: 9786208119713
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Enhancing Irbesartan Bioavailability via Solid Dispersion : Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Publicado por
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
Nuevo
Taschenbuch
Librería: AHA-BUCH GmbH, Einbeck, Alemania
Calificación del vendedor: 5 de 5 estrellas
Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 ¿g/ml) limits its bioavailability. This study aimed to improve Irbesartan¿s solubility through solid dispersions using carriers like ¿-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. ¿-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug¿s transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that ¿-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using ¿-cyclodextrin in solid dispersions effectively enhances Irbesartan¿s solubility and therapeutic potential in treating hypertension. Nº de ref. del artículo: 9786208119713
Cantidad disponible: 1 disponibles
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Publicado por
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
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Librería: Books Puddle, New York, NY, Estados Unidos de America
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Condición: New. Nº de ref. del artículo: 26403814798
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Publicado por
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
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Librería: Majestic Books, Hounslow, Reino Unido
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Condición: New. Print on Demand. Nº de ref. del artículo: 409339473
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Enhancing Irbesartan Bioavailability via Solid Dispersion (Paperback)
Publicado por
LAP Lambert Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
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Paperback
Librería: AussieBookSeller, Truganina, VIC, Australia
Calificación del vendedor: 5 de 5 estrellas
Paperback. Condición: new. Paperback. Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 mg/ml) limits its bioavailability. This study aimed to improve Irbesartan's solubility through solid dispersions using carriers like b-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. b-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug's transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that b-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using b-cyclodextrin in solid dispersions effectively enhances Irbesartan's solubility and therapeutic potential in treating hypertension. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability. Nº de ref. del artículo: 9786208119713
Cantidad disponible: 1 disponibles
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Enhancing Irbesartan Bioavailability via Solid Dispersion
Publicado por
LAP LAMBERT Academic Publishing Sep 2024, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
Nuevo
Taschenbuch
Librería: buchversandmimpf2000, Emtmannsberg, BAYE, Alemania
Calificación del vendedor: 5 de 5 estrellas
Taschenbuch. Condición: Neu. Neuware -Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 ¿g/ml) limits its bioavailability. This study aimed to improve Irbesartan¿s solubility through solid dispersions using carriers like ¿-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. ¿-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug¿s transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that ¿-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using ¿-cyclodextrin in solid dispersions effectively enhances Irbesartan¿s solubility and therapeutic potential in treating hypertension.Books on Demand GmbH, Überseering 33, 22297 Hamburg 84 pp. Englisch. Nº de ref. del artículo: 9786208119713
Cantidad disponible: 2 disponibles
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Publicado por
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
Nuevo
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Librería: Biblios, Frankfurt am main, HESSE, Alemania
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Condición: New. PRINT ON DEMAND. Nº de ref. del artículo: 18403814788
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Enhancing Irbesartan Bioavailability via Solid Dispersion (Paperback)
Publicado por
LAP Lambert Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
Nuevo
Paperback
Librería: CitiRetail, Stevenage, Reino Unido
Calificación del vendedor: 5 de 5 estrellas
Paperback. Condición: new. Paperback. Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 mg/ml) limits its bioavailability. This study aimed to improve Irbesartan's solubility through solid dispersions using carriers like b-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. b-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug's transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that b-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using b-cyclodextrin in solid dispersions effectively enhances Irbesartan's solubility and therapeutic potential in treating hypertension. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability. Nº de ref. del artículo: 9786208119713
Cantidad disponible: 1 disponibles