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DEVELOPMENT OF FENOPROFEN CALCIUM TABLETS FOR COLON TARGETING: FENOPROFEN CALCIUM TABLETS FOR COLON TARGETING - Tapa blanda

Shinde, Anilkumar; Gaikwad, Dinanath; More, Harinath

 
9786206739494: DEVELOPMENT OF FENOPROFEN CALCIUM TABLETS FOR COLON TARGETING: FENOPROFEN CALCIUM TABLETS FOR COLON TARGETING
Tapa blanda
ISBN 10: 620673949X ISBN 13: 9786206739494
Editorial: LAP LAMBERT Academic Publishing, 2025

Sinopsis

Objective: The objective of the present investigation was to development of enteric coated tablet of fenoprofen calcium. Methods: The 32factorial design was used to preparation of compression‐coated with a mixture of time dependent hydrophilic swellable polymer hydropropylcellulose (HPC), time released polymer Ethyl cellulose (EC) and pH responsive soluble polymer Instacoat EN Super II. The developed formulations were characterized for angle of repose, density, carr’s index of powder mixture and thickness, diameter, hardness, friability, weight variation, uniformity content, in vitro disintegration, dissolution study. Results: The results showed that disintegration time and dissolution study of inner core tablet found to be in the range of 7.15 to 13.34 min and 95.92±0.011% at 30 min. The press coat tablets at optimum concentrations of hydroxy propyl cellulose (200 mg) and ethyl cellulose N-22 (200 mg) showed the % drug release 83.53±0.014% at 12 hr. % cumulative drug release of enteric coated tablet of optimized batch FT9 showed 76.08±0.045 at 12h, it indicated that drug release at sustained manner.

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Editorial
LAP LAMBERT Academic Publishing
Año de publicación
2025
Idioma
Inglés
ISBN 10 
620673949X
ISBN 13 
9786206739494
Encuadernación
Tapa blanda
Número de páginas
56
Contacto del fabricante
no disponible
Persona responsable
no disponible