Design Development and In vitro characterisation of Dofetilide tablets: Based on Pulsatile Drug Delivery System - Tapa blanda

Jha, Sajal Kumar; Gore, Uday Kumar

 
9786202079884: Design Development and In vitro characterisation of Dofetilide tablets: Based on Pulsatile Drug Delivery System
Tapa blanda
ISBN 10: 6202079886 ISBN 13: 9786202079884
Editorial: LAP LAMBERT Academic Publishing, 2017

Sinopsis

The purpose of the book is to develop and characterize pulsatile drug delivery system of a novel drug Dofetilide. Initially the core tablets were prepared by using various concentrations of super disintegrates, the formulated core tablets were coated with the polymers by using compression coating technology. Sodium starch glycollate, cross povidone and cross carmellose sodium were the super disintegrants used in core tablet formulation. All the core and press coated tablet formulations were subjected to various physical and chemical evaluation tests for core and press coated tablets. The thickness, hardness and weight variation shown by all the tablet formulations were found within the official pharmacopoeial limits. The compression coating was done by using Eudragit S 100, Eudragit L 100 and ethyl cellulose as coating polymers. The maximum drug release data obtained by using combination of polymers in the ratio of 1:1. This book definitely will be useful for the researchers who wish to design and fabricate pulsatile drug delivery system for better therapeutic outcome.

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Reseña del editor

The purpose of the book is to develop and characterize pulsatile drug delivery system of a novel drug Dofetilide. Initially the core tablets were prepared by using various concentrations of super disintegrates, the formulated core tablets were coated with the polymers by using compression coating technology. Sodium starch glycollate, cross povidone and cross carmellose sodium were the super disintegrants used in core tablet formulation. All the core and press coated tablet formulations were subjected to various physical and chemical evaluation tests for core and press coated tablets. The thickness, hardness and weight variation shown by all the tablet formulations were found within the official pharmacopoeial limits. The compression coating was done by using Eudragit S 100, Eudragit L 100 and ethyl cellulose as coating polymers. The maximum drug release data obtained by using combination of polymers in the ratio of 1:1. This book definitely will be useful for the researchers who wish to design and fabricate pulsatile drug delivery system for better therapeutic outcome.

Biografía del autor

Dr. Sajal Kumar Jha, M.Pharm, Ph.D working as a Professor in School of Pharmacy, GNITC, Hyderabad. He is having 13 years of experience in academic activities and guided number of B.Pharm and M.Pharm students. He published 40 research papers in various National and International Journals. He served as life member of IPA, APTI, ISTE, ACPI, SPER, APP.

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Editorial
LAP LAMBERT Academic Publishing
Año de publicación
2017
Idioma
Inglés
ISBN 10 
6202079886
ISBN 13 
9786202079884
Encuadernación
Tapa blanda
Número de páginas
80
Contacto del fabricante
no disponible
Persona responsable
no disponible