Internal Ribosome Entry Site: Ribosome, Nucleic acid sequence, Protein biosynthesis, Eukaryote - Tapa blanda

Sinopsis

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. An internal ribosome entry site, abbreviated IRES, is a nucleotide sequence that allows for translation initiation in the middle of a messenger RNA sequence as part of the greater process of protein synthesis. Usually, in eukaryotes, translation can be initiated only at the 5' end of the mRNA molecule, since 5' cap recognition is required for the assembly of the initiation complex. These sequences were first discovered in 1988 in poliovirus RNA and encephalomyocarditis virus RNA in the labs of Nahum Sonenberg and Eckard Wimmer, respectively.

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