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Reducing GI side effects of NSAIDs by Mutual prodrug approach: Synthesis and evaluation of mutual prodrugs - Tapa blanda

Walsangikar, Sandeep D.; Bhatia, Neela M.; Bhatia, Manish S.

 
9783846551608: Reducing GI side effects of NSAIDs by Mutual prodrug approach: Synthesis and evaluation of mutual prodrugs
Tapa blanda
ISBN 10: 3846551600 ISBN 13: 9783846551608
Editorial: LAP LAMBERT Academic Publishing, 2012

Sinopsis

Prodrug has been the concept of retro metabolic drug design that incorporates targeting, metabolism and duration of action consideration into the design process. The carboxylic groups of NSAIDs can be temporarily masked and its direct effect on gastric mucosa can be minimized. Ester prodrugs of has been synthesized using various carrier moieties as reduce their GIT irritation and improve bioavailability. Prodrugs of several NSAIDs, such as diclofenac, Aspirin, ketoprofen etc have been synthesized using 1, 4-dihydro-1-methylpyridine-3-carboxylate as a carrier to brain to treat Alzheimer’s disease. Our aim is to reduce the gastric irritation due to direct contact of the drugs with the gastric mucosa and increased absorption using mutual prodrug approach.

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Reseña del editor

Prodrug has been the concept of retro metabolic drug design that incorporates targeting, metabolism and duration of action consideration into the design process. The carboxylic groups of NSAIDs can be temporarily masked and its direct effect on gastric mucosa can be minimized. Ester prodrugs of has been synthesized using various carrier moieties as reduce their GIT irritation and improve bioavailability. Prodrugs of several NSAIDs, such as diclofenac, Aspirin, ketoprofen etc have been synthesized using 1, 4-dihydro-1-methylpyridine-3-carboxylate as a carrier to brain to treat Alzheimer's disease. Our aim is to reduce the gastric irritation due to direct contact of the drugs with the gastric mucosa and increased absorption using mutual prodrug approach.

Biografía del autor

Mr. Walsangikar S. D. has completed his M. Pharmacy in Pharmaceutical Chemistry. He has published various research papers in international journals as author and contributed as co author in various research papers. He has excellant knowledge of synthetic chemistry. Currently he is working as Assistant Professor at GIPER Satara.

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Editorial
LAP LAMBERT Academic Publishing
Año de publicación
2012
Idioma
Inglés
ISBN 10 
3846551600
ISBN 13 
9783846551608
Encuadernación
Tapa blanda
Número de páginas
80
Contacto del fabricante
no disponible
Persona responsable
no disponible