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Modified alpha-beta Chimeric OligoDNA as a Unique Class of TFO: A Study on Synthesis and Properties of alpha-beta Chimeric OligoDNA - Tapa blanda

Azam, A.T.M. Zafrul

 
9783846532461: Modified alpha-beta Chimeric OligoDNA as a Unique Class of TFO: A Study on Synthesis and Properties of alpha-beta Chimeric OligoDNA
Tapa blanda
ISBN 10: 3846532460 ISBN 13: 9783846532461
Editorial: LAP LAMBERT Academic Publishing, 2011

Sinopsis

A series of novel alpha-beta chimeric oligodeoxynucleotides bearing either an intercalator-conjugated nucleobase located at the internal 4-nt linker region or an anthraquinone-conjugated propionic acid as a non-nucleosidic backbone unit at the internal linker region was synthesized. The UV-melting experiments reveled that the obtained modified chimera TFOs formed remarkably stable alternate-stranded triplex. On the other hand, modified TFOs bearing non-nucleosidic intercalator-conjugate possessed two diastereomers formed substantially stable alternate-stranded triple helix almost regardless of the stereochemistry of the incorporated non-nucleosidic backbone unit. The sequence discrimination ability and thermodynamic stability of some TFOs were also examined.

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Reseña del editor

A series of novel alpha-beta chimeric oligodeoxynucleotides bearing either an intercalator-conjugated nucleobase located at the internal 4-nt linker region or an anthraquinone-conjugated propionic acid as a non-nucleosidic backbone unit at the internal linker region was synthesized. The UV-melting experiments reveled that the obtained modified chimera TFOs formed remarkably stable alternate-stranded triplex. On the other hand, modified TFOs bearing non-nucleosidic intercalator-conjugate possessed two diastereomers formed substantially stable alternate-stranded triple helix almost regardless of the stereochemistry of the incorporated non-nucleosidic backbone unit. The sequence discrimination ability and thermodynamic stability of some TFOs were also examined.

Biografía del autor

Dr. Azam is working as an Assoc. Prof. for Faculty of Pharmacy, University of Dhaka, Bangladesh. His research interest is in Nucleic Acids and Medicinal Chemistry. He obtained his B.Pharm.(Hons.) and M.Pharm. from Univ. of Dhaka, Bangladesh; PhD from Gunma Univ., Japan. He worked as a JSPS Post-Doctoral research Fellow at Kanagawa Univ., Japan.

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Editorial
LAP LAMBERT Academic Publishing
Año de publicación
2011
Idioma
Inglés
ISBN 10 
3846532460
ISBN 13 
9783846532461
Encuadernación
Tapa blanda
Número de páginas
160
Contacto del fabricante
no disponible
Persona responsable
no disponible