Development of Self Microemulsifying Drug Delivery System: Preparation and evaluation of Lovastatin Self Microemulsifying Drug Delivery System - Tapa blanda

Patel, Mr.Maulik; Sanjay Patel, Dr.; Natvarlal Patel, Dr.

 
9783844331820: Development of Self Microemulsifying Drug Delivery System: Preparation and evaluation of Lovastatin Self Microemulsifying Drug Delivery System

Sinopsis

Nearly 40% of new drug candidates exhibit low solubility in water, which leads to poor oral bioavailability, high intra- and inter-subject variability and lack of dose proportionality. Modification of the physicochemical properties, such as salt formation and particle size reduction of the compound may be one approach to improve the dissolution rate of the drug. However, these methods have their own limitations. In recent years, much attention has focused on lipid based formulations to improve the oral bioavailability of poorly water soluble drugs. In fact, the most popular approach is the incorporation of the drug compound into inert lipid vehicles such as oils, surfactant dispersions, self-emulsifying formulations, emulsions and liposomes with particular emphasis on self-microemulsifying drug delivery systems (SMEDDS).

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Reseña del editor

Nearly 40% of new drug candidates exhibit low solubility in water, which leads to poor oral bioavailability, high intra- and inter-subject variability and lack of dose proportionality. Modification of the physicochemical properties, such as salt formation and particle size reduction of the compound may be one approach to improve the dissolution rate of the drug. However, these methods have their own limitations. In recent years, much attention has focused on lipid based formulations to improve the oral bioavailability of poorly water soluble drugs. In fact, the most popular approach is the incorporation of the drug compound into inert lipid vehicles such as oils, surfactant dispersions, self-emulsifying formulations, emulsions and liposomes with particular emphasis on self-microemulsifying drug delivery systems (SMEDDS).

Biografía del autor

Mr. Maulik J. Patel (Assistant Professor, Pharmaceutics Department), Dr. Sanjay S. Patel, (Associate Professor, Pharmaceutics Department) and Dr. Natvarlal M. Patel (Principal) working in Shri B. M. Shah College of Pharmaceutical Education and Research, Modasa – 383315, India

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Otras ediciones populares con el mismo título

9783659404795: Development of Self Microemulsifying Drug Delivery System: Design and Development of Self Microemulsifying Drug Delivery System of Clopidogrel Bisulphate

Edición Destacada

ISBN 10:  3659404799 ISBN 13:  9783659404795
Editorial: LAP LAMBERT Academic Publishing, 2013
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